Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
Microsatelite instability a marker of DNA mismatch repair, it typically found in?
A) herediatary nonpolyposis colon cancer B)familial adenomatous polyposis coli C) T-cell lymphoma D) B cell lymphoma E) myelogenous leukemia |
A) HNPCC
|
|
|
FAP (Familial adenomatous polposis coli) is due to what?
|
APC gene in chromosome 5
|
|
|
follicular lymphoma is due to what?
|
Bcl-2 expressed because it is translocated with the Ig heavy chain
|
|
|
which enzymes in the liver account for the activation of most procarcinogens into carcinogens?
A)cytochrome P450 dependent mono oxidases B)aminotransferases C) Hydroxylases D)Glutathione dehydrogenase E)Caspases |
A)cytochrome P450 dependent mono oxidases
|
|
|
what is associated with liver angiosarcoma?
|
Vinyl chloride
|
|
|
66 year old man presents with a pulmonary embolism and is found to have a DVT in his right leg. He is noted to have scleral icterus and slight jaundice. He reports having a 15 pound weight loss in the last 3 months or so and does admit to occasional vague abdominal pain. Additional work up would most likely reveal?
A) Pancreatic adenocarcinoma B)Pulmonary hamartoma C)SLE D)von Willibrand Factor deficiency E) widely metastatic prostate cancer |
pancreatic adenocarcinoma (think Trousseau)
|
|
|
A 25 year old woman presents for a gynecologic exam. She has HPV, what best explains the role of HPV?
A) activation of cellular oncogenes B)enchanced transcription of telomaerase gene C) episomal viral replication D) inactivation of tumor suppressor proteins E)insertional mutagenesis |
D) inactivation of tumor suppressor proteins
|
|
|
what gets affected by HPV (mechanistically)
|
P53 is broken down
|
|
|
list the 4 cellular oncogenes
|
c-kit, RET, HER-2, Ras
|
|
|
Pathologist identifies dysplastic squamous cells occupying the entire thickness of the cervical epithelium with no evidence of epithelial maturation. The basal membrane in these areas appears intact. Which of the following terms best describes this cervical lesion?
A)Atypical hyperplasia B)Carcinoma in situ C)carcinomatosis D)complex hyperplasia E)koilocytic atypia |
B)Carcinoma in situ
|
|
|
62 year old woman had a breast lump that was lobular carcinoma in situ. compared to normal epithelial cells of the breast lobule, these malignant cells would most likely show decreased expression of which of the following proteins
A)Desmin B)E-Cadherin C)Lysyl hydroxlyase D)P-selectin E)Telomerase |
B)E-Cadherin
|
|
|
65 year old man complains of muscle weakness and dry cough for 4 months. He has smoked two packs of cigarettes daily for 45 years. a chest xray shows a 4cm central left lung mass. lab studies show hyperglcemia and hypertension. a biopsy shows small cell carcinoma of the lung. what is causing the hyperglycemia and hypertension?
|
paraneoplastic syndrome
|
|
|
man has obstruction of left main stem bronchous due to mass in the left lung. biopsy shows which tumor marker?
a) alpha-fetoprotein b)calretinin c)carcinoembryonic antigen d)cytokeratins e)synaptophysin |
d) cytokeratins
|
|
|
60 year old man who worked in a chemical factory complains of blood in his urine. he has dysplastic cells. he has transitional cell carcinoma. which of the following carcinogens was most likely involved in the bladder cancer this guy has
a)aniline dyes b)arsenic c)benzene d)cisplatinum e)vinyl cholirde |
A) aniline dyes
(benzene is seem with leukemia) vinyl cholride (liver angiosarcoma) |
|
|
dude has HHV8 the patient most likely has which of the following diseases?
A)acquired immunodeficiency B)ataxia telangiectasia C)Li-Fraumeni syndrome D)Neurofibromatosis type I E) xeroderma pigmentosum |
A)acquired immunodeficiency
|
|
|
what is Li-Fraumeni syndrome
|
germline p53 mutation
|
|
|
dude comes in wiht a tumor and you tell him you need to stage that bad boy. which of the following is the most important staging factor
A)histological grade of tumor B)metastases to regional lymph nodes c)proliferation capacity of the tumor cells d)somatic mutations in p53 tumor suppressor gene |
B)metastases to regional lymph nodes
|
|
|
blah blah blah these neoplastic cells have most likely acquired a set of mutations that cause which of the following changes in cell behavior
A)decreased cellular motility B)enchanced stem-cell differentiation C)increased cell-cell adhesion D)increased susceptibility to apoptosis E) loss of cell cycle restriction point control |
E) loss of cell cycle restriction point control
|
