Pathology - S2B4 - Neuro 8

Front 1

Prion disease

Back 1

??

Front 2

Prion disease
-spongiform with plaques

Back 2

Dx?

Front 3

Prion disease
-plaques are shown...cool

Back 3

Dx?

Front 4

Alzheimers
-neurofibrillary tangles
-senile plaques

Back 4

Dx?

Front 5

Alzheimers
-senile plaques

Back 5

Dx?

Front 6

Alzheimers
-Senile plaques = Beta-amyloid
-neurofibrillary tangles = tau protein

Back 6

Whats the diagnosis bitches?

Front 7

Alzheimers
-neurofibrillary tangles

Back 7

Dx?

Front 8

Alzheimers
-nope, not Pick's disease u silly fuck

Back 8

Dx?

Front 9

Pick's Disease

Back 9

Dx?

Front 10

Pick's Disease
-Pick bodies = tau

Back 10

Dx?

Front 11

-Lewy bodies = contain alpha-synuclein protein
-Parkinson's

Back 11

What is this called?
What disease?

Front 12

Parkinson's with Lewy body

Back 12

Dx?

Front 13

This is a cause of Parkinsonism

Back 13

Multiple System Atrophy
-honestly, i don't know what the fuck is going on in this picture

Front 14

Multiple System Atrophy

Back 14

This causes Parkinsonism

Front 15

Progressive Supranuclear Palsy

Back 15

This is when many nuclei are involved & Parkinsonism also develops

Front 16

Progressive Supranuclear Palsy
-if this is on our test I will probably pull a Cho

Back 16

This is a cause of Parkinsonism

Front 17

Corticobasal Degeneration

Back 17

-Occurs in the motor, premotor cortex
-Ballooned neurons
-Tau-positive inclusions in Astrocytes, Oligos, neurons
-causes Parkinsonism

Front 18

ALS

Back 18

This disease affects Anterior horn cells in Spinal Cord & Motor nuclei in Brain stem

Front 19

ALS = degeneration of axons/myelin in Lateral & Anterior Corticospinal tracts

*this is also a xeroxed copy of my mom's ass during a drunken work christmas party

Back 19

Dx?

Front 20

ALS

Back 20

Dx?

Front 21

Huntington Disease = chorea + dementia

Back 21

Dx?

Front 22

Huntington Disease
-atrophy of Caudate Nucleus, Putamen, Frontal Cortex

Back 22

Pathology on right?

Front 23

Friedrich's Ataxia
-Posterior = diminished joint sensation
-Lateral = spasticity

Hypertrophic Cardiomyopathy

Back 23

Loss of posterior & lateral columns of Spinal Cord?
Most frequent cause of death in this disorder?

Front 24

Acute Hemorrhagic Leukoencephalitis

Hyperacute, follows respiratory infection

Back 24

What is this?
Describe the clinical scenario

Front 25

Acute Hemorrhagic Leukoencephalitis

Back 25

WHat is seen here?

Front 26

Progressive Multifocal Leukoencephalopathy = JC virus...aka the Jesus Christ virus

Back 26

What is seen here?

Front 27

Progressive Multifocal Leukoencephalopathy
-occurs in IC'ed patients

Back 27

Dx?

Front 28

Central Pontine Myelinosis

Person comes in who is Hyponatremic --> rapid correction causes this

Back 28

Dx?
Clinical scenario?

Front 29

Adrenoleukodystrophy

Unable to Beta-oxidize "very long chain fatty acids" = LCFA's in peroxisomes

Back 29

What is seen here?
Mechanism?

Front 30

Adrenoleukodystrophy
-LCFA in peroxisomes
-parieto-occipital myelin loss

Back 30

Dx?

Front 31

Metachromatic Leukodystrophy

Arylsulfatase A deficiency = Autosomal Recessive
-Sulfatides accumulate
-Children = motor symptoms
-Adults = psychiatric symptoms

Back 31

Dx?
Mechanism?

Front 32

Multiple Sclerosis

Back 32

Patient has Oligoclonal bands in CSF...diagnosis?

Front 33

Multiple Sclerosis

Back 33

Dx?

Front 34

Multiple Sclersosis - Balo's Concentric type

Back 34

Dx?