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34 Cards in this Set

  • Front
  • Back
Prion disease
??
Prion disease
-spongiform with plaques
Dx?
Prion disease
-plaques are shown...cool
Dx?
Alzheimers
-neurofibrillary tangles
-senile plaques
Dx?
Alzheimers
-senile plaques
Dx?
Alzheimers
-Senile plaques = Beta-amyloid
-neurofibrillary tangles = tau protein
Whats the diagnosis bitches?
Alzheimers
-neurofibrillary tangles
Dx?
Alzheimers
-nope, not Pick's disease u silly fuck
Dx?
Pick's Disease
Dx?
Pick's Disease
-Pick bodies = tau
Dx?
-Lewy bodies = contain alpha-synuclein protein
-Parkinson's
What is this called?
What disease?
Parkinson's with Lewy body
Dx?
This is a cause of Parkinsonism
Multiple System Atrophy
-honestly, i don't know what the fuck is going on in this picture
Multiple System Atrophy
This causes Parkinsonism
Progressive Supranuclear Palsy
This is when many nuclei are involved & Parkinsonism also develops
Progressive Supranuclear Palsy
-if this is on our test I will probably pull a Cho
This is a cause of Parkinsonism
Corticobasal Degeneration
-Occurs in the motor, premotor cortex
-Ballooned neurons
-Tau-positive inclusions in Astrocytes, Oligos, neurons
-causes Parkinsonism
ALS
This disease affects Anterior horn cells in Spinal Cord & Motor nuclei in Brain stem
ALS = degeneration of axons/myelin in Lateral & Anterior Corticospinal tracts

*this is also a xeroxed copy of my mom's ass during a drunken work christmas party
Dx?
ALS
Dx?
Huntington Disease = chorea + dementia
Dx?
Huntington Disease
-atrophy of Caudate Nucleus, Putamen, Frontal Cortex
Pathology on right?
Friedrich's Ataxia
-Posterior = diminished joint sensation
-Lateral = spasticity

Hypertrophic Cardiomyopathy
Loss of posterior & lateral columns of Spinal Cord?
Most frequent cause of death in this disorder?
Acute Hemorrhagic Leukoencephalitis

Hyperacute, follows respiratory infection
What is this?
Describe the clinical scenario
Acute Hemorrhagic Leukoencephalitis
WHat is seen here?
Progressive Multifocal Leukoencephalopathy = JC virus...aka the Jesus Christ virus
What is seen here?
Progressive Multifocal Leukoencephalopathy
-occurs in IC'ed patients
Dx?
Central Pontine Myelinosis

Person comes in who is Hyponatremic --> rapid correction causes this
Dx?
Clinical scenario?
Adrenoleukodystrophy

Unable to Beta-oxidize "very long chain fatty acids" = LCFA's in peroxisomes
What is seen here?
Mechanism?
Adrenoleukodystrophy
-LCFA in peroxisomes
-parieto-occipital myelin loss
Dx?
Metachromatic Leukodystrophy

Arylsulfatase A deficiency = Autosomal Recessive
-Sulfatides accumulate
-Children = motor symptoms
-Adults = psychiatric symptoms
Dx?
Mechanism?
Multiple Sclerosis
Patient has Oligoclonal bands in CSF...diagnosis?
Multiple Sclerosis
Dx?
Multiple Sclersosis - Balo's Concentric type
Dx?