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71 Cards in this Set
- Front
- Back
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How are Ovarian Tumors classified?
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1. tumors of surface epithelium
2. Germ cell tumors 3. Sex Cord stromal tumors |
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Epithelial ovarian tumor that has Fallopian Tube-like epithelium
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Serous
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Epithelial Ovarian tumors with Endocervical-like epithelium
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Mucinous
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Epithelial Ovarian tumor that is malignant and resembles Endometrium
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Endometrioid
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Rare, malignant Epithelial Ovarian Tumor that is composed of sheets of cells filled with Glycogen
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Clear cell
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Benign Epithelial Ovarian tumor with nests of cells resembling bladder Transitional Epithelium interspersed in fibrous stroma
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Brenner tumor
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Describe the histology of Serous Cystadenoma's
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Single layer of Ciliated Tubal-type epithelium
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Serous Cystadenoma = benign cysts with Fallopian Tube-like epithelium
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What is this showing?
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What is the gross appearance of Mucinous Cystadenoma?
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1. vary in size
2. Cystic, Multilocular 3. Thick mucinous fluid |
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What is the histology of Mucinous Cystadenoma?
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Tall Columnar cells filled mucin
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Mucinous Cystadenoma
Benign |
What is this showing?
Benign or Malignant? |
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Brenner Tumor = benign tumor with islands of Transitional-like epithelium in a fibrous stroma
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What is this showing?
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This is the MOST COMMON MALIGNANT tumor of the Ovary
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Serous Cystadenocarcinoma = 30% of all Ovarian CA's
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This ovarian cancer has Psammoma bodies
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Papillary Serous Cystadenocarcinoma
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Papillary Serous Cystadenocarcinoma
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What are all these showing?
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Papillary Serous Cystadenocarcinoma
Psammoma body |
What are these showing?
What specifically is the bottom showing? |
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A malignant ovarian tumor that can rupture or metastasize and produce Pseudomyxoma Peritonei with multiple peritoneal tumor implants, all producing large quantities of intraperitoneal mucinous material
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Mucinous Cystadenocarinoma
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Mucinous Cystadenocarcinoma
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What are all of these showing?
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Endometrioid Adenocarcinoma
Malignant |
What is this showing?
Benign or Malignant? |
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Clear Cell Adenocarcinoma of the ovary
Prognosis is even worse than the bad prognosis that we have for other ovarian cancers |
What is this showing?
What is important about it? |
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What is the lab finding in Malignant Epithelial Ovarian Tumors?
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CA-125
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What are the clinical features of Malignant Epithelial Ovarian Tumors
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1. BAD prognosis
2. Early metastasis 3. Peritoneal implants 4. CA-125 5. Treatment: Surgery, chemo, radiotherapy |
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What are the 4 Malignant Epithelial Ovarian TUmors?
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1. Serous Cystadenocarcinoma
2. Mucinous Cystadenocarcinoma 3. Endometroid 4. Clear cell |
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What are the 3 Benign Epithelial Ovarian Tumors?
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1. Serous Cystadenoma
2. Mucinous Cystadenoma 3. Brenner tumor |
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What are the key features of Borderline Epithelial Ovarian Tumors
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1. Low malignant potential
2. worrisome histology, excellent prognosis 3. Serous or Mucinous 4. Epithelial stratification, mitosis, atypia 5. NO STROMAL INVASION |
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What is the treatment for Borderline Epithelial Ovarian Tumors?
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Surgery, even with Metastasis
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Borderline Epithelial Ovarian tumors
-Left = Mucinous tumor -Right = Serous tumor **NO Stromal Invasion |
What are these showing?
-Left? -Right? |
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Jelly-belly = Numerous Peritoneal implants of Mucus-secreting cells
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Pseudomyxoma Peritonei
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What are the possible sources of Pseudomyxoma Peritonei?
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1. Mucinous Cystadenocarcinoma
2. Mucinous Cystadenoma 3. Carcinomatous mucocele of the appendix 4. Bowel |
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What is the treatment for Pseudomyxoma Peritonei?
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-repeated debulking
- Chemotherapy |
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This is the most Malignant Germ Cell tumor of the Ovary
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Dysgerminoma = Ovarian Seminoma
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What is Dysgerminoma analogous to in the male?
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Testicular Seminoma
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Germ cell ovarian tumor with glycogen-filled tumor cells
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Dysgerminoma
-similar to Seminoma cells of Testicular germ cell tumors |
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What age group does Dysgerminoma commonly occur at?
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10-30 years
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What is the prognosis of Dysgerminoma?
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Excellent prognosis
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Most common Germ Cell Tumor
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Mature Teratoma = Dermoid cyst
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Describe the key properties of Mature Teratomas
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1. Benign
2. 3 germ cell layers 3. Cystic |
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What is Struma Ovarii?
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Mature Teratoma comprised of almost all Thyroid tissue = can show high Thyroid levels in a patient with normal Thyroids
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Mature Teratoma
Benign |
What are these showing?
Benign or Malignant? |
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Mature Teratoma
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What is this?
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Dermoid cysts of Mature Teratomas
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What are these?
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Mature Teratoma
Several different tissues present |
What is this?
How do you know? |
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Germ cell tumor that has 3 Germ Cell layers, is Malignant, has embroyonal tissue that is usually neural
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Immature Teratoma
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Immature Teratoma
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What are these?
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Another name for Endodermal Sinus Tumor
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Yolk Sac Tumor
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-Highly malignant
-affects a young age group -tumor is hemorrhagic and necrotic -Schiller-Duval bodies |
Endodermal Sinus Tumor = Yolk Sac tumor
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Germ cell tumor that secretes AFP
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Endodermal Sinus Tumor = Yolk Sac tumor
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A girl with ovarian cancer at the age of 3
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Yolk Sac tumor
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Yolk Sac Tumor
Schiller-duval bodies |
What ovarian tumor?
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Agressive and malignant ovarian tumor with areas of necrosis and hemorrhage composed of neoplastic Syncytiotrophoblasts and Cytotrophoblasts
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Choriocarcinoma of the ovary
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A young girl presents with precocious sexual development. She yields a + pregnancy test with the presence of hCG. She swears she is a virgin
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Choriocarcinoma
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Choriocarcinoma of the Ovary
Syncytiotroph's and Cytotroph's with areas of necrosis and hemorrhage |
What tumor is this?
How do you know? |
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What syndrome is associated with an increased risk for Dysgerminoma?
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Turner's syndrome
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What are the 3 Ovarian Sex Cord Stromal tumors
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1. Fibroma-Thecoma
2. Granulosa Cell tumor 3. Sertoli-Leydig cell tumor |
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Most common Sex Cord / Stromal tumor
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Fibroma
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When do most Ovarian Fibroma's occur?
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around Menopause
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A woman presents with Ascitis (distended stomach) and Pleural effusions (hydrothorax). What tumor does she most likely have? What syndrome is this?
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Ovary Fibroma (Sex cord tumor)
Meig's Syndrome |
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What is the clinical triad in Meig's Syndrome?
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1. Ovarian Fibroma
2. Ascites = distended stomach 3. Pleural effusion |
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Ovarian Fibroma
Benign |
What is this tumor?
Benign or Malignant? |
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Benign, POSTMENOPAUSAL Ovarian tumor that has round lipid-containing cells in addition to fibroblasts. Also secretes Estrogen
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Ovarian Thecoma
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What are Thecomas associated with increasing the risk of? Why?
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Endometrial Hyperplasia and Endometrial Cancer
Because they secrete Estrogen |
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Thecoma
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This was shown to secrete Estrogen, what is it?
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Ovarian tumor:
-secretes Estrogen -Call-Exner bodies -associated with Endometrial Hyperplasia/Cancer |
Granulosa Cell Tumor
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Granulosa Cell Tumor
Call-Exner bodies = follicles filled with Eosinophilic secretions |
What is this tumor?
What are the characteristic features on the right? |
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Granulosa Cell Tumor
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A girl with this tumor (Coffee-bean nuclei) came in and was found to have Precocious Puberty. She was also at an increased risk of Endometrial Hyperplasia/Cancer
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Ovarian tumor that secretes Androgen
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Sertoli-Leydig Cell tumors = Androblastoma = Arrhenoblastoma
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A 25 year old woman presented with facial and chest hair. She was found to have what ovarian tumor?
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Sertoli-Leydig Cell tumor
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Androgens
Sertoli-Leydig Cell tumor |
What do these cells secrete?
What tumor? |
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What are the properties of Metastatic Ovarian cancer? Where do they commonly come from?
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Usually BILATERAL
Breast, Colon, Stomach |
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What are Krukenburg Tumors?
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1. Adenocarcimona mucin-producing
2. Contains Signet Ring Cells from the Stomach |
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Krukenberg tumors = bilateral
Gastric Adenocarcinoma |
After histologic examination, there appeared to be Signet Ring Cells in the specimen.
-What is the name of this tumor? -Where did it likely come from? |
