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9 Cards in this Set
- Front
- Back
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T/F you need morphologic evaluation for all lymphomas
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true
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paraffin section immunohistochemisty
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ideal for hodgkin disease
lymphoid vs nonlymphoid |
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Flow cytometry
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B cell neoplasms will show kappa OR lambda only (not both) showing clonality
normal B cells show a mix T cell neoplasm show deletion of a pan T cell antigen OR codeletion or coexpression of CD4 and CD8 |
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diffuse large B cell lymphoma
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diffuse and large cells
panB+ (CD19, CD20, CD22) CD45/LCA+ most common NonHodgkin lymphoma originates from peripheral b-cell |
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follicular lymphoma
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t(14,18) - bcl-2 gene rearranged next to Ig heavy chain -> overexpressed bcl-2 antiapoptotic
PanB+, CD10+, CD5-, bcl2+ originates from germinal center b-cell - forms nodules |
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mantle cell lymphoma
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t(11,14) -> bcl-1 and cyclin D1 overexpressed
PanB+ CD5+, CD10-, CD23- derives from follicle mantle |
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marginal zone lymphoma
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CD5-, CD10-
associated with autoimmune disease form lymphoepithelial lesions originate from marginal zone of MALT |
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nodular sclerosis hodgkin disease
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PanB- CD45/LCA+, CD15+, CD30+
see lacunar and classic reed-sternberg cells |
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immunophenotype of:
diffuse large B cell follicular mantel marginal zone lymphoma nodular sclerosis hodgkin disease |
Diffuse large bcell lymphoma - PanB+, CD45/LCA+
follicular cell lymphoma - PanB+, CD10+, CD5-, bcl2+ mantel cell lymphoma - PanB+, CD5+, CD10-, CD23- marginal zone lymphoma - PanB+, CD5-, CD10- nodular sclerosis hodgkin lymphoma - CD45/LCA-, PanB-, CD15+, CD30+ |
