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11 Cards in this Set
- Front
- Back
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What is the definition of atherosclerosis and what is it a subset of?
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Pathological process of forming atheroma. It is a subset of arteriosclerosis
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What is the natural history of atherosclerosis?
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Takes years to develop with punctuated acute "events" that rapidly alter the lesion.
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What are the most common areas for atherosclerosis to occur? (3)
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Areas of non-laminar flow:
1. branch points 2. curvatures 3. regions of complex blood flow |
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What are the disease manifestations of atherosclerosis? (6)
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1. Coronary artery disease 2. abdominal aortic aneurysm 3. cerevrovascular disease (stroke) 4. peripheral vascular disease 5. mesenteric disease 6. renovascular disease
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What are the broad categories of risk factors for developing atherosclerosis? (5)
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Genetic, Life habits, hemodynamic factors, oxidative & inflammatory factors, hormonometabolic factors
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What are the anti-atherosclerotic properties of an endothelial cell?
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anti-inflammatory, anti-thrombotic, anti-proliferative, anti-oxidative, vasodilatory, selectively permeable
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What are the pathological correlates of atherosclerotic coronary artery disease? (6)
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1. stable eccentric atheroma (with tin fibrous cap + necrotic core, stable fibromusclar plaque, stable fibrocalcific plaque)
2. acute plaque hemorrhage with rapid expansion 3. atherosclerosis with non-occlusive thrombus 4. atherosclerosis with occlusive luminal thrombus 5. atherosclerosis with recanalized, organized thrombus 6. atherosclerosis with obliterated lumen |
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Wear does acute myocardial infarction start and where does it go to in the heart?
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subendocardial zone then spreads transmural
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What are the complications of acute myocardial infarction? (6)
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1. arrhythmia/suddent death 2. free wall or septal rupture 3. mitral insufficiency/acute heart failure 4. papillary muscle rupture 5. aneurysm/mural thrombus/embolus 6. congestive heart failure (chronic)
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What is the most common cause of a heart attack?
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Arrhythmic death but damaged myocardium or acutely ischemic myocardium is often a precipitating factor ie - most have atherosclerotic disease but they do not die of an MI
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Is MI synonymous with heart attack?
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No, it is just one cause of a heart attach and is not the most common
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