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8 Cards in this Set

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  • Back
What type of tumor causes Cushing's syndrome, and what does it secrete?
small cell lung carcinoma; ACTH or ACTH-like peptide
What type of tumors causes SIADH, and what does it secrete?
small cell lung carcinoma and intracranial neoplasms; ADH or ANP
What types of tumors can elicit a paraneoplastic effect of hypercalcemia?
squamous cell lung carcinoma, renal cell carcinoma, breast carcinoma, multiple myeloma, bone metastasis (lysed bone)
What substance mediates the paraneoplastic effects of squamous lung carcinomas?
PTH-related peptide (causes hypercalcemia)
What is a common paraneoplastic effect of renal cell carcinomas?
secretion of erythropoeitin -> polycythemia
What types of tumors can elicit paraneoplastic myasthenic syndromes (e.g. Lambert-Eaton syndrome)?
Thymoma, bronchogenic carcinoma; via antibodies against presynaptic Ca channels at neuromuscular junction
What are the common paraneoplastic effects of lymphomas and leukemias?
gout, urate nephropathy; from hyperuricemia due to excess nucleic acid turnover (i.e. cytotoxic therapy)
What type of tumor can produce the paraneoplastic syndrome of migratory thrombophlebitis?
pancreatic carcinoma