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8 Cards in this Set
- Front
- Back
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What type of tumor causes Cushing's syndrome, and what does it secrete?
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small cell lung carcinoma; ACTH or ACTH-like peptide
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What type of tumors causes SIADH, and what does it secrete?
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small cell lung carcinoma and intracranial neoplasms; ADH or ANP
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What types of tumors can elicit a paraneoplastic effect of hypercalcemia?
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squamous cell lung carcinoma, renal cell carcinoma, breast carcinoma, multiple myeloma, bone metastasis (lysed bone)
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What substance mediates the paraneoplastic effects of squamous lung carcinomas?
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PTH-related peptide (causes hypercalcemia)
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What is a common paraneoplastic effect of renal cell carcinomas?
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secretion of erythropoeitin -> polycythemia
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What types of tumors can elicit paraneoplastic myasthenic syndromes (e.g. Lambert-Eaton syndrome)?
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Thymoma, bronchogenic carcinoma; via antibodies against presynaptic Ca channels at neuromuscular junction
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What are the common paraneoplastic effects of lymphomas and leukemias?
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gout, urate nephropathy; from hyperuricemia due to excess nucleic acid turnover (i.e. cytotoxic therapy)
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What type of tumor can produce the paraneoplastic syndrome of migratory thrombophlebitis?
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pancreatic carcinoma
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