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10 Cards in this Set
- Front
- Back
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Definition of Inflammation:
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local reaction of tissue to an injurious agent
tissue injury leads to - healing/restoration of structure, function - cell death variable response (individuality) situation dependent dose dependent |
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cardinal signs (grossly)
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- dolor pain
- rubor erythemia - tumor swelling - calor heat - functio laesa loss of function |
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Inflammation Cascade : Name the steps
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1) cloudy Swelling
- reversible - may progress to cell death - see inc H2O w/in mito - dissociation of ribosomes from ER 2) vasoconstriction - nerve stimulus shuts down blood vessel - results in pain 3) arteriole dilation - soon follows constriction 4) inc blood flow - erythemia 5) venous/capillary dilation - follows from arteriole pressure 6) blood stasis - extreme changes in pressure - blood "slows down" 7) vascular permeability - inc blood volume from dec velocity - pushes out at walls 8) transudate - inc H20;Ab 9) exudate - inc WBC - stick to walls; migrate thru |
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Inflammation is caused by:
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caused by :
inc vascularity inc blood flow inc vascular permeability transudation exudation pressure on nerves release of kinens |
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Classifications of Inflammation
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Location
Exudate Duration |
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Types of location of Inflammaton:
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- cellulitis
dec damage hyperemia cells removed 100% heal - abscess associated w/liquifaction necrosis extensive necrosis inc lymphocytes - ulcer abscess broken thru surface |
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Types of exudate:
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- transudate
sterile fluid w/ few cells specific gravity < 1.015 protein content < 3g% clear; inc Ab content - exudate non-sterile (bacteria) inc cell pop inc sp. gravity inc protein content 1) serous almost clear slight yellow color inc H20 2) fibrinous fibrin-like; "stringy" yellow/red color inc protein content 3) purulent suppurative thick; gray/yellow/green color inc PMNs associated w/bacteria+cell death 4) catarrhal mucous (mucus-producing) associated w/mucosal inflammation thick; gray/white color "ropey" 5) sanguineous bloody hemorrhagic |
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Duration of Inflammation
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- acute
leukocytic response pruritus abscess, ulcer swelling/edema/discharge empyema pus in mesothelial cavity EX=> hematuria kidney jaundice liver hemoptysis lung hematemesis stomach - chronic dec tissue damage inc lymphocyte/macro fibrosis EX=> chronic cholelithiosis granulomatous spherical macro ball epitheliod giant cells - TB (necrotizing) - sarcoid (solid) - fungus - syphilis - brucellosis - beryllia - Hodgkin's - RA (rheumatoid arthritis) - tuleremia foreign body reaction inc foreign body giant cell in response to organic material - suture - ingrown hair - EIC (epidermal inclusion cyst) |
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What involves acute inflammation?
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leukocytic response
pruritus abscess, ulcer swelling/edema/discharge empyema |
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What involves Chronic inflammation?
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dec tissue damage
inc lymphocyte/macro fibrosis |
