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45 Cards in this Set
- Front
- Back
- 3rd side (hint)
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I say Type I Hypersensitivity, you say:
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Mast Cells, Basophils, Eosinophils, & IgE
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I say Type III Hypersensitivity, you say:
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Ag-Ab Complexes, & PMNs/Complement System
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I say Type II Hypersensitivity, you say:
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Antibody Mediated
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What are Urticaria?
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Hives
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List 3 symptoms of asthma:
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Bronchoconstriction, mucus production, & Laryngeal Edema
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Name two diseases involved in Type II antibody membrane binding:
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Graves Disease & Myasthenia Gravis
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I say linear distribution, you say:
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Coating in type II hypersensitivity.
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What is deposition of Ag-Ab complexes in blood vessels called?
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"Vasculitis"
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What is deposition of Ag-Ab complexes in a glomerulus called?
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Glomerulonephritis
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Streptococcus in the kidney causes:
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APGN (acute post-streptococcal glomerulonephritis)
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What does major basic protein do?
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Damages and kills bystander cells.
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Early phase type I involves (2):
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Recruitment of PMEs & Mast cell degranulation
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Late phase type I involves (2):
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Major Basic Ptn destruction & Eosinophil degranulation
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Give two GI anaphylactic responses:
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Vomiting & Diarrhea
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What can type I caused vasodilation result in?
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Anaphylactic shock
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Give three type II vascular reactions discussed in class:
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Blood type rejection, Penicillin opsonization, Erythroblastosis fetalis
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Linear distribution can be observed in:
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Goodpasture's Syndrome (type II hypersensitivity)
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Give 4 results of complement activation:
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Phagocytosis, MAC (membrane attack), Chemotaxis, & Mast cell degranulation.
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Give three things involved in vasculitis:
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Microembolisms/Microthrombosis, Fibrin accumulation, Ischemia downstream
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Arthritis is a type ____ Hypersensitivity:
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Type III
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If you see CD4s and CD8s, you're thinking:
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Delayed Hypersensitivity (Type IV)
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What's the reason for the delay?
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CD4s are slow.
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Is allergic contact dermatitis granulomatis or non?
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Non-granulomatis.
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Perivascular accumulation, aka:
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"Cuffing"
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Macrophages go to ____, which are ____ phagocytic cells present in CT.
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Histiocytes are stationary phagocytic cells.
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Histiocytes are seen in type ____ hypersensitivity reactions?
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Type IV
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What are signs of chronic allergic contact dermatitis(2)?
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Scales & lichenification
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What are signs of acute allergic contact dermatitis(3)?
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Redness, Pain, Swelling, etc.
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Granular distribution seen in type ____ hypersensitivity?
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Type III
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What are some symptoms of SLE (7)?
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Red eye, joint pain, fatigue, alopecia, Malar rash (butterfly), photosensitivity, & chest pain.
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What are some signs of SLE?
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Increased: ANA (anti-nuclear antibodies), ESR (erythrocyte sedimentation rate), & anti-Smith Antibodies, Decreased: C5a, C3a
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What type of hypersensitivity reaction takes place in SLE?
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Type II
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What is the pathophysiology behind SLE?
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Abnormalities in apoptosis ("An apoptotic event causes blebs which aren’t destroyed (usually they are)")
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How can you treat SLE?
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Steroids & antimalaria drugs (one can also use immunosuppressants).
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What is Raynaud's Phenomenon?
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RWB Fingertips seen in SLE ("very patriotic").
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What organ systems are affected by SLE the most?
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Hematologic (100%), Joints, Skin, CNS (50%), Kidneys, Heart, GI tract, Eye (15%)
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What type of hypersensitivity reaction takes place in JRA?
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Type III
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What is an Ulnar deformity?
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Hand cramps from JRA
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Can you recall the difference between SLE and JRA mentioned in class?
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JRA affects the body more symmetrically than SLE (somewhat random).
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What are some symptoms of JRA (4)?
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Scleritis/Episcleritis, Bilateral joint pain, Fatigue, no systemic (extra-joint) pain.
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What is RF?
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Rheumatoid Factor (It is an antibody against the Fc portion of IgG).
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What is Sjögren's Syndrome (SS)?
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An autoimmune disorder against exocrine glands (lacrimal, meibomian, salivary, urogenital, etc.)
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What's the difference between lab tests for Sjögren's Syndrome & SLE?
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No anti-Smith Ab in Sjögren's Syndrome (both will have ANA), although SS may arise secondary to SLE/JRA, etc.
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Which autoantibody will be present in the serum of an SSA patient?
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Antibodies to Ro extractable nuclear antigens.
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None
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Which autoantibody will be present in the serum of an SSB patient?
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Antibodies to La extractable nuclear antigens.
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None
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