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42 Cards in this Set

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leukocyte rolling mediated by
Sialyl-Lewis X (leukocyte)

E-selectin (vascular endothelium)
leukocyte tight binding mediate by
LFA-1 (leukocyte)

ICAM-1 (vascular endothelium)
reversible or irreversible:

dysplasia
reversible
associated neoplasm:

tuberous sclerosis (2)
- facial angiofibroma
- seizures
- mental retardation
astrocytoma

cardiac rhabdomyoma
associated neoplasm:

Plummer-Vinson syndrome
- atrophic glossitis
- esophageal webs
- anemia
(due to Fe deficiency)
SCC of esophagus
associated neoplasm:

ulcerative colitis
colonic adenocarcinoma
associated neoplasm:

Paget's disease of the bone (2)
secondary osteosarcoma

fibrosarcoma
associated neoplasm:

immunodeficiency states
malignant lymphoma
associated neoplasm:

AIDS (2)
aggressive malignant lymphomas
- non-Hodgkin's lymphoma
- Kaposi's sarcoma
associated neoplasm:

dysplastic nevus
malignant melanoma
oncogene:

erb-B2 (3)
breast cancer
ovarian cancer
gastric carcinoma
oncogene:

ras
colon carcinoma
oncogene:

N-myc
neuroblastoma
tumor suppressor gene:

Rb

- chromosome
- associated tumors (2)
13q

retinoblastoma

osteosarcoma
tumor suppressor gene:

BRCA1

- chromosome
- associated tumors (2)
17q

breast cancer
ovarian cancer
tumor suppressor gene:

BRCA2

- chromosome
- associated tumors (2)
13q

breast cancer
ovarian cancer
tumor suppresor gene:

p53

- chromosome
- associated tumor (specific)
17p

most human cancers
Li-Fraumeni syndrome
tumor suppresor gene:

p16

- chromosome
- associated tumor
9p

melanoma
tumor supprssor gene:

APC

- chromosome
- associated tumor
5q

colorectal cancer
tumor suppressor gene:

DPC

- chromosome
- associated tumor
18q

pancreatic cancer
tumor suppressor gene:

DCC

- chromosome
- associated tumor
18q

colon cancer
tumor marker:

CEA (4)
colorectal cancer
pancreatic cancer
gastric carcinoma
breast carincoma
tumor marker:

β-hCG (3)
choriocarcinoma
hydatidiform mole
gestational trophoblastic tumor
tumor marker:

CA-125 (2)
ovarian tumors
malignant epithelial tumors
tumor marker:

S-100 (3)
melanoma
neural tumors
astrocytomas
tumor marker:

alkaline phosphatase (3)
metastasis to the bone
Paget's disease of the bone
obstructive biliary disease
tumor marker:

bombesin (3)
neuroblastoma
lung cancer
gastric cancer
tumor marker:

CA-19-9
pancreatic adenocarcinoma
chemical carcinogen:

vinyl chloride
angiosarcoma (liver)
chemical carcinogen:

nitrosamines (2)
esophagus
stomach
chemical carcinogen:

asbestos (2)
bronchogenic carcinoma
mesothelioma
chemical carcinogen:

alkylating agents
luekemia
paraneoplastic effects of tumors:

small cell lung carcinoma
ACTH

(causes Cushing's syndrome)
paraneoplastic effects of tumors:

small cell lung carcinoma and intracranial neoplasms
ADH

(causes SIADH)
paraneoplastic effects of tumors:

squamous cell lung carcinoma
PTH-related peptide

causes hypercalcemia
paraneoplastic effects of tumors:

renal cell carcinoma (2)
erythropoietin
- causes polycythemia

PTH-related peptide
- causes hypercalcemia
paraneoplastic effects of tumors:

breat carcinoma
PTH-related peptide

causes hypercalcemia
paraneoplastic effects of tumors:

thymoma
Ab's against presynaptic Ca2+ channels at NMJ

causes muscle weakness (Lambert-Eaton syndrome)
paraneoplastic effects of tumors:

small cell lung carcinoma (in addition to ACTH and ADH)
Ab's against presynaptic Ca2+ channels at NMJ

causes muscle weakness (Lambert-Eaton syndrome)
primary tumors that metastatize to the brain (5)
Lung
Brain
Skin (melanoma)
Kidney (renal cell carcinoma)
GI tumors

Lots of Bad Stuff Kills Glia
primary tumors that metastasize to the liver (in order of prevalence)
colon > stomach > pancreas > breast > lung
primary tumors that metastazie to the bone

- lytic, blastic, or both (if applicable)

- most common (2)
prostate - blastic (rock-hard prostate)
thyroid
testes
breast - lytic and blastic
lung - lytic
kidney

(P. TT. Barnum Loves Kids)

prostate
breast