Pathology: Hematopathology: Lymphoma, Block I

Front 1

Symptoms such as fever, night sweats, loss of appetite, and weight loss are called what?

Back 1

Constitutional or B symptoms

Front 2

85% of non-Hodgkin Lymphoma is which type?

Back 2

B Cell

Front 3

This disease is defined by the presence of Reed Sternberg cells and variants which are derived from lymph node germinal center B cells

Back 3

Hodgkin Lymphoma

Front 4

What is the most common type of Hodgkin Lymphoma?

Back 4

Nodular Sclerosis

Front 5

Represent 85% of all lymphomas:

Back 5

B cell lymphoma

Front 6

B cell lymphoid malignancies are __________, which means that the population all derived from one cell and produce all the same type of heavy and light chains

Back 6

Monoclonal

Front 7

A proliferation of large neoplastic B lymphoid cells, has a diffuse growth pattern

Back 7

DLBCL

Front 8

Typical presentaion is a rapidly enlarging, often symptomatic mass at a single nodal or extranodal site

Back 8

DLBCL

Front 9

Lymphoma exibiting pan B-cell markers (CD19, CD20, CD22, CD79a)

Back 9

DLBCL

Front 10

This disease can be caused by translocation of Bcl-6 gene which causes dysregulation of germinal centers

Back 10

DLBCL

Front 11

This disease is associated with the translocation of Bcl2-gene t(14:18) and may arise in follicular lymphoma

Back 11

DLBCL

Front 12

Immunodeficiency related DLBCL is usually associated with which virus?

Back 12

EBV

Front 13

The DLBCL found in body cavitites is associated with which virus?

Back 13

AIDS

Front 14

A neoplasm of B cells arising from the lymphoid follicle germinal center

Back 14

Follicular Lymphoma

Front 15

This tumor arises from germinal center B cells and is strongly associated with chromosomal translocations involving BCL2- has centrocytes and centroblasts

Back 15

Follicular Lymphoma

Front 16

Which CD marker indicates follicular center origin? In which cancers is this found?

Back 16

CD10 - found in ALL and follicular lymphoma

Front 17

The hallmark of this disease is a 14:18 translocation that juxtaposes IgH and BCL2:

Back 17

Follicular Lymphoma

Front 18

This disease involves translocation of 14:18 in 90% of cases:

Back 18

Follicular Lymphoma

Front 19

This is the most common form of NHL and is often associated with dysregulation of BCL-6.

Back 19

DLBCL

Front 20

B cell tumors that arise within lymph nodes, spleen, or extranodal tissues- neoplastic infiltrate is in the marginal zone of reactive follicles and extends into the interfollicular region

Back 20

MALT - Marginal Zone Lymphomas

Front 21

What organ/system is usually involved in MALT? Why?

Back 21

GI Tract- Stomach. Because it starts with H. Pylori gastritis and lymphoid hyperplasia

Front 22

A neoplasm of small B cells, same as CLL but clinical involvement is of tissue- mean age is 65 and mostly male

Back 22

Small Lymphocytic Lymphoma

Front 23

SLL/CLL may transform to high grade lymphoma which is associated with poor prognosis and called what?

Back 23

Richter Syndrome

Front 24

Mantle Cell lymphomas express high levels of what?

Back 24

Cyclin D1

Front 25

B cell neoplasm composed of small to medium sized cells, most commonly involves lymph nodes but may be extranodal, has a median age of 60, and tumor cells closely resemble mantle zone B cells thast surround germinal centers

Back 25

Mantle Cell Lymphoma

Front 26

Cyclin D over-expression associated with Mantle Cell lymphoma is caused by which gene translocation?

Back 26

t(11:14) involving IgH locus and cyclin D

Front 27

This tumor exhibits a high mitotic index and contains numerous apoptotic cells, tissue has a starry sky pattern:

Back 27

Burkitt Lymphoma

Front 28

This highly aggressive lymphoma often presents at extranodal sites and involves the same mature B cells that cause ALL.

Back 28

Burkitt's Lymphoma

Front 29

All forms of this disease are associated with the translocation of the c-MYC gene on chromosome 8

Back 29

Burkitt's Lymphoma

Front 30

This disease is associated with EBV, c-MYC and commonly has mutations that inactivate p53.

Back 30

Burkitt's Lymphoma

Front 31

This disease is associated with masses in jaw bone, facial bones, abdomen and often has CNS involvement:

Back 31

Burkitt's Lymphoma

Front 32

Therapy of Burkitt's Lymphoma may cause rapid cell death and lead to hyperkalemia, what is this called?

Back 32

Tumor Lysis Syndrome

Front 33

This disease involves translocation of the c-MYC gene from chromosome 8 to heavy or light chain gene loci - this is thought to affect the progression through the G2 phase of the cell cycle

Back 33

Burkitt's Lymphoma

Front 34

This disease is characterized by Reed Sternberg cells with a background of reactive inflammatory cells

Back 34

HL

Front 35

This disease arises first in a node or chain of nodes and spreads predictably to anatomically contigious lymphoid tissuea

Back 35

HL

Front 36

95% of cells in Hodgkin Lymphoma 95% are of what origin?

Back 36

B cell

Front 37

This is a nodal based disease with contiguous spread that usually presents with painless enlargement of lymph nodes and fever, night sweats and unexplained weight loss.

Back 37

HL

Front 38

This is the most common form of HL

Back 38

Nodular Sclerosis Type

Front 39

This type of HL is characterized by the presence of lacunar variant and the deposition of collagen in bands that divide involved lymph nodes into circumscribed nodules

Back 39

Nodular Sclerosis type

Front 40

A subtype if HL with collagen bands that surround nodules and lacunar type HRS cells, median age is 28, 80% of cases have medistinal involvement

Back 40

Nodular Sclerosis HL

Front 41

This form of HL makes up 20-25% of cases- RS cells are infected with EBV in about 70% of these cases- most cases are male.

Back 41

Mixed cellularity HL.