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19 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What does Hypoxia mean?
-How does it cause cell injury |
O deprevation
-Reducing Aerobic Oxidative Respiration |
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What is Ischemia?
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Hypoxia is O deprevation and Ischemia is O deprevation due to loss of blood supply from impeded blood flow or reduced venous drainage
-loss of O and substrates (glucose to tissues) |
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How do you get hypoxia?
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-Blood isnt Oxgenated due to
-Cardiac Respirator Failure RBC carry less O (CO Poising,Anemia) |
2 ways
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What cells are O sensitive and which cells are not O sensitive?
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Neuron (O sensitive)
Muscle (Can adjust>> Anerobic Respiration) |
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Name the 7 Causes of Injury
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1-O Deprevation
2-Physical Agents 3-Chemical Agents and Drugs 4-Infectious Agents 5-Immunologic Reactions 6-Genetic Derangements 7-Nutrional Imbalances |
General Categories
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Which category does Mechanical trauma, extreme temperatures, sudden changes in atmospheric pressure,radiation, and electrical shock
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Physical Agents
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Gives some examples of Chemical Agents and Drugs.
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Chemical Agents
-Glucose and Salt in Hypertonic Concentrations Drugs -Arsenic, Cyanide, Mercuric Salts |
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Can Insecticides, Herbicides, Air pollutants, CO, Absestos, Alcohol and Narcotic Drugs result in cell injury
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Only in large concentrations
-Known as Daily Companions |
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Name Infectious Agents that can cause cell injury
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Bacteria
Viruses Parasites |
3 listed
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The anaphylactic reaction to a foreign protein or drug is a prime exampe of this category
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Immunologic Reactions
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Antibody-Antigen
Autoimmune Response |
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The following phrases describe this category which causes cell injury:
-Inborn Errors of Metabolism from enzymatic Abnormalities -Down's Syndrome -Sickle Cell Anemia |
Genetic Derangements
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Describe how Nutritional Imbalance can injure cells
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Protein Calorie Def
Vitamin Def Nutrional Excess Cells either have the nutrients necessary to function or don't// they can also have too much |
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Excess lipids can cause what diseases
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Atherosclerosis
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Programmed Cell Death
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Apoptosis
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Always Pathogenic, Cell Death
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Necrosis
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Cells have 5 Vital Systems. If these systems are disrupted cell injury will result. Name the 5 Vital Systems
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1-Aerobic Respiration for ATP
2-Osmotic and Ionic Balance 3-Protein Synthesis 4-Structural Maintaince and Intracellular Transport (cytoskeleton) 5-Nucleus Function |
Energy
Homeostasis of Ions Synthesis of Proteins Stucture Brain of the Cell |
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How does the cell maintaing an osmotic and ionic balance
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ion compartmentalization
-If disrupted cell injury results |
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T or F. The cellular response to injurious stimuli depends on the type of injury, its duration, and its severity.
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True
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Name the 3 Molecular Mechanisms of Injury
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ATP Depletion
Increased Cytosolic Ca Free Radical Generation |
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