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53 Cards in this Set

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Dz Asso. W/ neoplasm
Down syndrome
ALL (we ALL fall DOWN)
AML
Dz Asso. W/ neoplasm
Xeroderma pigmentosum
Melanoma, basal cell, squamous cell
Dz Asso. W/ neoplasm
Chronic atrophic gastritis, pernicious anemia, post-surgical gastric remnants
Gastric adenocarcinoma
Dz Asso. W/ neoplasm
Tuberous sclerosis
Astrocytoma, cardiac rhabdomyoma
Dz Asso. W/ neoplasm
Actinic Keratosis
SCC
Dz Asso. W/ neoplasm
Barretts' Esophagus
Esophageal Adenocarcinoma
Dz Asso. W/ neoplasm
Plummer-Vinson Syndrome
(Esophageal webs, atrophic glossitis, anemia - all due to iron deficiency)
SCC of esophagus
Dz Asso. W/ neoplasm
Cirrhosis (EtOH, Hep B or C)
Hepatocellular carcinoma
Dz Asso. W/ neoplasm
UC
Colonic adenocarcinoma
Dz Asso. W/ neoplasm
Paget's Dz of Bone
Secondary Fibrosacroma, osteosarcoma
Dz Asso. W/ neoplasm
Immunodeficiency States
Malignant Lymphomas
Dz Asso. W/ neoplasm
AIDS
Aggressive Malignant Lymphomas (non-Hodgkins)
Kaposi Sarcoma (HSV-8)
Dz Asso. W/ neoplasm
Autoimmune Dz
Benign and malignant thymoma
Dz Asso. W/ neoplasm
Acanthosis nigricans
Viscaral malignancy
(stomach, lung, breast, uterus)
abl
CML
c-myc
Burkitt's lymphoma
L-myc
Lung Cancer
N-myc
Neuroblastoma
bcl-2
Follicular and undifferentiated lymphomas
t(14;18)
erb-B2
Breast, Ovarian, Gastric Carcinomas
ras
Colon carconoma
ret
Type II and Type III MEN
Rb
13q
retinoblastoma, osteosarcoma
BRCA1 and BRCA2
17q and 13q
Breast and ovarian cancer
p53
17p
Most human cancers
Li-Fraumeni syndrome (AD mutation in p53, multiple tumors)
p16
9p
melanoma
APC
5q
colorectal adenocarcinoma
WT1
11q
Wilms Tumor
NF1
17q
Neurofibromatosis type 1
AD - skin lesions, possible brain lesions
NF2
22q
AD - Acoustic Neuromas
DPC
18q
Pancreatic cancer
DCC
18q
Colon Cancer
Tumor Marker:
PSA
Prostate Specific Antigen
Screening for prostatic carcinoma
Tumor Marker:
CEA
Carcinoembryonic Antigen
70% of Colorectal and Pancreatic Cancers
Also produced by gastric and breast cancers
Tumor Marker:
Alpha-fetoprotein
Hepatocellular Carcinoma
Non-seminomatous germ cell tumors of the testis (yolk sack tumor)
Tumor Marker:
B-hCG
Hydatidiform mole
Choriocarcinomas
Gestational Trophoblastic tumors
(e.g. Hydatidiform moles (complete and incomplete), choriocarcinomas (malignancy of the placenta))
Tumor Marker:
CA-125
Ovarian, malignant epithelial tumors
Tumor Marker:
S-100
Melanoma
Neural Tumors
Astrocytoma
Tumor Marker:
Alkaline Phosphatase
Bone Mets
Pagets Dz of Bone
Obstructive biliary dz
Tumor Marker:
Bombesin
Neuroblastoma
Lung Cancer
Gastric Cancer
BOMB BLAST (neuroblastoma)
burns the LUNGS
Guts Everywhere (gastric cancer)
Tumor Marker:
TRAP
Tartrate-resistant acid phosphatase
Hairy Cell Leukemia
Tumor Marker:
CA-19-9
Pancreatic Adenocarcinoma
Oncogenic Virus:
HTLV-1
Adult T-Cell Leukemia
Oncogenic Virus:
HBV, HCV
Hepatocellular Carcinoma
Oncogenic Virus:
EBV (2)
Burkitt's Lymphoma
Nasopharyngeal Carcinoma
Oncogenic Virus:
HPV
Cercvical Carcinoma (HPV 16, 18)
Penile/Anal Carcinoma
Oncogenic Virus:
HHV-8
Kaposi Sarcoma
Body cavity fluid B-Cell Lymphoma
Paraneoplastic Effect of Tumor:
Small Cell lung Carcinoma
ACTH or ACTH-like peptide - Cushing Syndrome
ADH - SIADH
-also caused by some intracranial neoplasms
Paraneoplastic Effect of Tumor:
Squamous Cell Lung Carcinoma
PTH-rp
Hypercalcemia
Also TGF-B
TNF-A
IL-1
Paraneoplastic Effect of Tumor:
Renal Cell Carcinoma
Breast Carcinoma
Multiple Myeloma
Bone Mets
PTH-rp Hypercalcemia
Also TGF-B
TNF-A
IL-1
Paraneoplastic Effect of Tumor:
Renal Cell Carcinoma
Hemangioblastoma
Erythropoietin- polycythemia
Paraneoplastic Effect of Tumor:
Thymoma, Small Cell Lung Carcinoma
Antibodies against presynaptic Ca++ channels and NMJ
-Lambert Eaton syndrome (muscle weakness)
Paraneoplastic Effect of Tumor:
Leukemias and lymphomas
Hyperuricemia due to excess nucleic acid turnover (i.e. cytotoxic therapy)

-Gout, urate nephropathy