Pathology - Bodies

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Councilman Bodies: (/acidophil bodies)

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apoptotic, eosinophilic hepatocytes extruded into the sinuses

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Adria cell:

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cardiac myocyte which has lost its cross-striations and myofilaments secondary to Adriamycin toxicity

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Aschoff bodies:

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foci of fibrinoid necrosis within the myocardium of a patient with acute rheumatic fever

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Asteroid bodies

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acidophilic, stellate inclusions in giant cells in sarcoidosis and berylliosis

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Auer Rods

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red-rod shaped lysosomes (abnormal) seen in malignant cells of predominantly M3 acute myelogenous leukemia

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Barr Bodies:

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inactivated X chromosome - dark staining mass in contact with the nuclear membrane

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Birbeck granules:

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“Tennis racket” shaped granules in cytoplasm of Langerhans cells (histiocytosis X) with trilaminar “handle”

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Blue-Blobs:

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atrophy in Pap-smears

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Blue bodies:

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laminated PAS+ iron containing bodies in alveolar macrophages of desquamative interstitial pneumonia

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Call-Exner bodies:

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small gland like “follicles” filled with acidophilic material often seen in ovarian granulosa cell tumors

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Caterpillar cells:

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large multinucleated giant cells with lengthwise chromatin clumping in nucleus; appear owl eyed on cross section; seen in heart in acute rheumatic fever

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Charcot-Leyden crystals:

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crystals shaped like double pyramids; found in sputum of asthma patients; made by eosinophils

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Councilman Bodies:

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apoptotic, eosinophilic hepatocytes extruded into the sinuses

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Corpora Amylacea:

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Represent a degenerative change in astrocytes. Basophilic and PAS positive polyglucosan globules in terminal processes of astrocytes. Number increases with age. Can also be found in nodular hyperplasia of prostate.

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Corpora Arantii:

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small fibrous nodules at the centers of the semilunar valve cusps along the lines of closure

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Cowdry type A inclusions:

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acidophilic intranuclear inclusion separated from the nuclear membrane by an artifactual cleft - typical of Herpes infected cells (HSSV, VZV)

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Curschmann’s spirals:

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twisted mass of mucus seen in sputum of patients with asthma

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Donovan body:

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intracellular bacillus (Calymmatobacterium donovani) seen in histiocytes in the genital skin of patients affected with granuloma inguinale

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Dutcher bodies:

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“intranuclear” inclusions of immunoglobulin in plasmacytoid cells

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Faggot cells:

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malignant promyelocytes of M3 AML containing numerous Auer rods like “sticks in a fireplace”

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Gandy-Gamna bodies:

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calcium and hemosiderin deposits in the spleen: seen in setting of increased hemolysis

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Glomus bodies:

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regulated arteriovenous anastomoses in the skin which play a role in thermoregulation (many in fingers and toes). Glomus tumour can arise. The tumour is bening, but painful, most often seen under nails.

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Guarneri bodies:

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Epidermal cells with eosinophilic cytoplasmic inclusions in skin of patients with smallpox

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Hassall’s corpuscles:

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concentric aggregates of keratinized epithelial cells and keratin in the medulla of the thymus

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Heinz bodies:

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clumps of precipitated oxidized hemoglobin in the cytoplasm of red cells

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Hirano body:

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eosinophilic, football shaped inclusion seen in neurons of the brain; part of normal aging, but more numerous in Alzheimer’s disease

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Hutchinson’s teeth:

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inflammatory destruction of the teeth seen in tertiary syphilis

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Hutchinson’s triad

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Hutchinson’s teeht, keratitis, eight nevre deafness

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Kamino bodies:

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Intraepidermal hyaline globules seen in a Spitz nevus ("benign juvenile melanome", but, it's not a melanoma, and can also occure in adults..old term)

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Kayser-Fleischer rings:

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rings of discoloration on cornea of patients with Wilson’s disease (AR, copper accumulates, symptoms; neurological or psychiatric or liver disease;hepatitis, cirrhosis, necrosis)

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Koplik’s Spots:

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spotty lesions that blister and ulcerate deep in the cheek mucosa; diagnostic for measles

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Lambl’s excrescences:

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small fibrin vegetations overlying sites of endothelial damage of flow side of cardiac valves

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LE bodies (AKA hematoxylin bodies):

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nuclei of damaged cells with bound anti-nuclear antibodies which become homogeneous and loose chromatin pattern. When phagocytosed, form LE cells, Seen in SLE

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Lewy bodies:

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round, concentrically laminated, pale eosinophilic cytoplasmic inclusions seen in neurons in Parkinson’s disease

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Libman-Sacks nodules:

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non-bacterial verrucous cardiac valve leaflet vegetations seen in SLE

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Lipofuscin Granules:

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polymers of lipid complexed with proteins - responsible for brown atrophy

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Lisch Nodules:

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pigmented iris hamartomas seen in patients with type I neurofibromatosis

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Loose Bodies:

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fragments of bone or cartilage which become detached into the joint space; may continue to grow by surface apposition; centers eventually necrose and calcify

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MacCallum’s plaques:

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map-like thickening of the endocardium over myocardial lesions in acute rheumatic fever

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Mallory Bodies:

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alcoholic hyalin - eosinophilic intracytoplasmic inclusions in hepatocytes: intermediate filaments, predominantly prekeratin. Found in alcoholic hepatitis, alcoholic cirrhosis, Wilson's disease, primary-biliary cirrhosis, non-alc cirr, hepatocellular ca., morbid obesity.

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Michaelis-Gutmann bodies:

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partially digested bacteria, (calcified) in stroma and in cells; seen in Malakoplakia ( rare inflammatory condition which makes its presence known as a papule, plaque, ulcers)

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Negri Bodies:

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bullet shaped cytoplasmic inclusions in neurons (especially Purkinje cells); pathognomonic for rabies infection

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Nemaline Bodies:

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Z-bands seen by EM in degenerative skeletal muscle diseases

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Neurofibrillary Tangles:

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microtubule-associated proteins and neurofilaments, seen in Alzheimer’s disease

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Physaliferous cells:

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very large tumor cells with bubbly vacuolated cytoplasm (some glycogen) and vesicular nuclei, seen in chordomas

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Reinke crystalloid:

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crystals found in Leydig cells of testes: hexagonal prisms, tapered ends, moderately electron dense

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Rokitansky’s protuberance:

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central area of an ovarian mature cystic teratomas containing bone and well formed teeth

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Rosenthal fibers:

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intracytoplasmic hyaline structure, sometimes corkscrew shaped, found in pilocytic astrocytes

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Russell Bodies:

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cytoplasmic immunoglobulin (du to overproduction) inclusions in plasma cells or plasmacytoid cells

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Schaumann bodies:

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concentrically laminated inclusions (up to 50µm) in giant cells seen in sarcoidosis and berylliosis

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Schiller-Duval bodies:

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endodermal sinuses: glomeruloid structures seen in yolk sac tumors

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Smudge cell:

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cell with a large, ovoid nucleus filled with granular amphophilic to deeply basophilic mass and an indistinct nuclear membrane; seen in Adenovirus infected cells

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Soldier’s plaque:

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white thickening of the epicardium from a healed pericarditis

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Sulfur Granules:

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yellow foci of Actinomyces

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Sucquet-Hoyer canals:

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shunts of Glomus bodies, involved in thermal regulation

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Verocay bodies:

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palisades of nuclei at the end of a fibrillar bundle in a Schwannoma (Neurilemoma)

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Warthin-Finkeldey cells:

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multinucleated giant cells with eosinophilic nuclear and cytoplasmic inclusions found in lymphoid organs of patients with measles

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Weibel-Palade bodies:

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Rod-shaped cytoplasmic organelles in endothelial cells containing von Willebrand factor

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Zebra Bodies:

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palisaded lamellated membranous cytoplasmic bodies seen by EM in macrophages of patients with Niemann-Pick disease, Tay-Sachs disease, or any of the mucopolysaccharidoses

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Zellballen:

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clusters of tumor cells surrounded by a thin fibrovascular stroma, seen in pheochromocytoma and extra-adrenal paragangliomas