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9 Cards in this Set

  • Front
  • Back
ulcerative colitis (UC)
- grouped with Crohn disease as IBD
- inflammation and ulceration limited to the large intestine
- inflammation is confined to the mucosa dn submucosa
- crypt abscess
- red, granular appearance of mucosa
- pseudopolyps (mucosal remnnats of previous severe ulceration)
- chronic diarrhea and bleeding
what are some complications of ulcerative colitis?
- toxic megacolon-
- perforation of the color
- carcinoma of colon
crohn's disease
- commonly involves distal ileocecum, small intestine, or colon
- affects young people (20-30)
- can lead to carcinoma of small int and the colon (neoplasm is less comon than in UC though!)
- inflammation involves all wall layers
- skip lesions
- non caseating granulomas
how does Crohn's disease present?
- abdominal pain and diarrhea
- malabsorption
- fever
- intestional obstruction resulting from fibrous stricture
- fistulas between loops of intestine and between intestine, bladder, vagina and skin
adenocarcinoma of the colon and rectum
- one of the most common neoplasms of the western world
- peak incidence: 60s-70s
- associated with increased serum concentrations of carcinoembryonic antigen (CEA)
- normal mucosa -> adenomatous polyp -> carcinoma -> metastatic tumor
what can carcinoembryonic antigen (CEA) tell you
- is a marker for adenocarcinoma of the colon and rectum, but not specific
- better for following the course of the disease rather than for making the initial diagnosis
what are predisposing factors to adenocarcinoma of the colon and rectum?
- adenomatous polyps
- inherited multiple polyposis syndromes
- long standing UC
- family history
- low fiber diet high in animal fat
describe differences sen in carcinoma of the rectosigmoid colon vs carcinoma of the right colon
rectosigmoid colon: presents in annular manner -> early obstruction
right colon: does not obstruct early. presents with iron deficiency anemia secondary to blood loss
intestinal TB
- rare condition
- seen in immunodepressed patients
- see ulcerations of the mucosa and caseating granulomas