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11 Cards in this Set

  • Front
  • Back
__________ is accumulation of conformationally abnormal proteins that are resistant to proteolysis.
pathogenesis of misfolding diseases
__________ refers to the nongenetic forms of misfolding diseases.
____________ alter gene expression in teh absence of nucleotide mutations eitehr in the gene of interest or elements controlling gene expression.
Epigenetic events
3 broad areas of epigenetic events:
nuclear modification, ecternal stimuli, conformational
______implies that proteins have a normal primary sequence, but during or after translation they fail to adopt or transform from the normal 3-d structure.
Conformational abnormalities
__________ is multiple amino acids enoded by the same nucletide.
nucleotide degeneracy
______occurs when there is a sparcity of amino acids and therefor proteins are not able to conform correctly.
kinetic bottlenecks
________ means the presence of a misfolded protein may serve as a template for misfolding of normal proteins.
what percent of proteins normally produced are mistranslated or misfolded.
T/F Normally the cells ID abnormal proteins, tags them with ubiquitin, and captures them, then isolates them or recycles them with foldases.
Sometimes the mechanism responsible for degradation of misfolded proteins is_______________.
impaired due to secondary genetic mutations