Pathologic Rbc Forms

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Acanthocyte ( spur cell)
Liver disease, abetalipoproteinemia ( states of cholesterol dysregulation).

Acantho = spiny

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Basophilic stippling
Thalassemias, Anemia of chronic disease, Lead poisoning

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Bite cell
G6PD deficiency

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Elliptocyte
Hereditary elliptocytosis

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Macro-ovalocyte
Megaloblastic anemia (also hyper segmented PMNs), marrow failure.

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Ringed sideroblasts
Sideroblastic anemia. Excess iron in mitochondria = pathologic.

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Schitocyte, helmet cell
DIC, TTP/HUS, traumatic hemolysis (metal heart valve prosthesis)

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Sickle cell
Sickle cell anemia

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Spherocyte
Hereditary spherocytosis, autoimmune hemolysis.

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Teardrop cell
Bone marrow infiltration (myelofibrosis)

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Target cell
HbC disease, Asplenia, Liver disease, Thalassemia

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Heinz Bodies
Seen in G6PD deficiency; Heinz body-like inclusions seen in alpha-thalasemia.

Oxidationn of iron from ferrous to ferric form leads to denatured hemoglobin precipitation and damaged to RBC membrane- formation of bite cells.

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Howell-Jolly bodies
Seen in pt w functional hyposplenia or aspleni, or after mothball ingestion (naphthalene).

Basophilic nuclear remmanents found in RBC. Howell-Jolly bodies are normally removed from RBC by splenic macrophages.

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Anatomy