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23 Cards in this Set
- Front
- Back
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Describe the structure of Pseudomonas aeruginosa.
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Gram negative rods, catalase and oxidase positive, motile by flagella. Colonies often mucoid appearance and green pigmentation.
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How do Pseudomonas aeruginosa grow best?
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Aerobically, but can respire anaerobically by using nitrate as an alternate electron receptor. Limited nutritional requirements.
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What are some virulence factors of pseudomonas aeruginosa?
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LPS, pili, polar flagella, enzymes that break down tissue and facilitate spread, capsule, Exotoxin, Exoenzymes, TTSS, beta lactamases, siderophores, endotoxin.
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How does pseudomonas aeruginosa attach to the host cell surface?
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via the pili and the polar flagella.
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What are the enzymes that break down tissue and facilitate spread (invade)?
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Elastase, Phospholipase, and proteases.
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What type of toxin is exotoxin A?
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An A-B subunit toxin.
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What is the purpose of exoenzymes S and T?
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to cause host cell damage.
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What are the normal defenses againse Pseudomonas aeruginosa?
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Normal flora, intact skin, and neutrophils.
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What does it mean to be neutropenic?
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Having a low neutrophil count (like cancer patients)
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Where is pseudomona aeruginosa found?
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Everywhere, in soil, water plants. Prefers moist environments.
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What are some infections caused by Pseudomonas aeruginosa?
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CNS, localized infections, Bacteremia, endocarditis, UTI, respiratory tract infection, skin and skeletal muscle would infections.
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What are some respiratory infections cause by pseudomona aeruginosa?
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Hospital acquired acute pneumonia associated with mechanical ventilators, and chronic infections in people with cystic fibrosis.
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How do skin infections develop?
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People who are in the water a lot, such as hot tubs, or have their hands in the water a lot. Or burn victims. Moist skin is key to being colonized.
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What enables colonization in burn wounds?
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Moist skin and lack of neutrophils.
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What can result from burn wounds that have infections?
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bacteremia and necrosis.
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Describe the cause and occurance of folliculitis.
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Occurs in people who use hot tubs. Self-limited to normal patients.
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What are UTI's and Pseudomonas aeruginosa assocaited with?
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Long term catheters
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What type of ear infection is Pseudomonas aeruginosa responsible for?
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swimmer's ear
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What are eye infections of Pseudomonas aeruginosa associated with?
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develop either after initial eye trauma or with contaminated lens solution.
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What is an ecthyma grangrenosum?
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A patch of skin that identifies bacteremia in pseudomonas aeruginosa.
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How does bacteremia occur in Pseudomonas aeruginosa?
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Can follow burn, respiratory, and UTI infections. Associated with neutropenic patients.
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What type of patients are usually associated with endocarditis in pseudomonas aeruginosa?
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IV drug users.
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Why is treatment of Pseudomonas aeruginosa complicated?
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high level of antibiotic resistance --> many antibiotics are used to treat severe infections. Also, the underlying immunosuppression of infected patients.
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