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12 Cards in this Set

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What is scleroderma?
It is a chronic progressive disease of connective tissue, and involves the excessive deposition of collagen and affects about 3 females to 1 male.
Scleroderma is a systemic disorder primarily affecting the GI tract the heart and its vasculature, the kidneys , lungs and muscular system. TRUE/FALSE
TRUE. the pathology arises from increased activity of fibroblasts laying down collagen and from impaired local circulation.
What is the pathogenesis of PSS?
There appears to be a dysfunction at ther level of both the fibroblasts and microvasculature. Apparantly, collagen reactive T cells and b cells mediate the pathology. the response of autoreactive helper T cells to their encounter with collagen sets up a cycle of progression.
Collagen reactive B cells could produce antibodies that form complexes and mediate vascular damage. TRUE/FALSE
TRUE. These processes set stage for scar formation, because the tissue is robbed of adequate blood supply.
Platelet adherence in the injured vessels contributes to the stimulation of fibroblasts because of the factors released. TRUE/FALSE
TRUE. As in other diseases identified as auto immune, there are abnormalities of immune function, such as circulating antinuclear antibodies.
What are acute phase proteins?
Also known as acute phase reactants, some to levels of 500-1000 fold higher than normal. they are produced largely by the liver, and these proteins prime the plasma for contributing to the inflammatory response.
List several of these reactive proteins.
1. C reactive protein(CRP)
2. Serum amyloid associated protein(SAA)
3. Serum amyloid P protein(SAP).
These bind directly to the surface of pathogens, esp. bacteria to enhance phagocytosis(opsonization)
In a chronic inflammation, the prolonged presence of SAA leads to the deposition, in certain individuals of Amyloid A fibrils. TRUE/FALSE
TRUE. This secondary amyloidosis interferes with the function of the organ within which it is deposited.
What are acute phase proteins?
Also known as acute phase reactants, some to levels of 500-1000 fold higher than normal. they are produced largely by the liver, and these proteins prime the plasma for contributing to the inflammatory response.
List several of these reactive proteins.
1. C reactive protein(CRP)
2. Serum amyloid associated protein(SAA)
3. Serum amyloid P protein(SAP).
These bind directly to the surface of pathogens, esp. bacteria to enhance phagocytosis(opsonization)
In a chronic inflammation, the prolonged presence of SAA leads to the deposition, in certain individuals of Amyloid A fibrils. TRUE/FALSE
TRUE. This secondary amyloidosis interferes with the function of the organ within which it is deposited.
What is henoch-Schonlein purpura?
In this condition, the ESR(erythrocyte sedimentation rate) is persistently elevated.
The ESR is the time it takes to red cells to settleut of a blood sample. Increased times are taken to be caused by a higher plasma fibrinogen content, which renders the plasma more viscous. It produces a generalized vasculitis, which gives rise to patchy blood loss into the skin)purpora) as well into the abdomen anf joints.