Patho - Infl, Repair, Immuno

Front 1

Histamin mediates which parts of infl 2

Back 1

Rubor, calor

Front 2

By what mech? 2

Back 2

Arteriolar vasodilation; venular perm incr

Front 3

Mast cells release which type of histamine granules?

Back 3

PREFORMED

Front 4

Primary WBC of acute infl

Back 4

Neutrophils

Front 5

Selectins are responsible for neutrophil

Back 5

rolling

Front 6

Associated with?

Back 6

LAD-2

Front 7

beta-integrins are responsible for neutrophil

Back 7

adhesion

Front 8

What are the CD?

Back 8

CD 11a: CD 18

Front 9

Associated with?

Back 9

LAD-1

Front 10

3 chemicals that inh adhesion -> leukocytosis

Back 10

Cats, steroids, Li

Front 11

Delayed separation of umbilical cords suggests

Back 11

LAD-1 or LAD-2

Front 12

2 main opsinins

Back 12

IgG, C3b

Front 13

Bruton's agammaglobinemia is a defect in

Back 13

opsonization

Front 14

Resp burst is detected with

Back 14

NBT dye test

Front 15

Chronic granulomatous dz is a defect in

Back 15

NADPH oxidase

Front 16

Genetics?

Back 16

XR

Front 17

Show what type of resp burst?

Back 17

Absent (no NADPH for H2O2, O2-)

Front 18

MPO def would show what type of resp burst?

Back 18

Norm (O2- & H2O2 but no bleach)

Front 19

Genetics?

Back 19

AR

Front 20

4 cytokines causing vasodilation

Back 20

histamine, NO, PGI2, 5HT

Front 21

1 cytokine causing vasoconstriction

Back 21

TXA2

Front 22

6 cytokines causing incr vessel perm

Back 22

histamine, bradykinin, LTC-E4, C3a, C5a, 5HT

Front 23

2 cytokines producing pain

Back 23

PGE2, bradykinin

Front 24

3 cytokines producing fever

Back 24

PGE2, IL-1, TNF

Front 25

3 chemotactic cytokines

Back 25

C5a, LTB4, IL-8

Front 26

4 types of acute infl

Back 26

purulent, fibrinous, serous, pseudomembranous

Front 27

Which type is bread & butter heart?

Back 27

fibrinous

Front 28

What is the possible complication?

Back 28

adhesion

Front 29

What S. aureus factor makes it trap bacteria & neutrophils?

Back 29

Coagulase

Front 30

Blisters are which type of infl?

Back 30

serous

Front 31

Fever fx on O2 curve?

Back 31

R-shift

Front 32

Lipoxin fxn? 2

Back 32

inhibit chemotaxis, promote phagocytosis of apoptotic bodies

Front 33

Derived from

Back 33

arachodonic acid

Front 34

Resolvin fxn? 2

Back 34

Inh production & recruitment of infl cells

Front 35

Derived from

Back 35

omega-3 FA

Front 36

4 consequences of acute infl

Back 36

resolution, scar, abscess, chronic infl

Front 37

Primary WBC of chronic infl

Back 37

macrophages

Front 38

Key adhesion gp in ECM

Back 38

fibronectin

Front 39

key adhesion gp in BM

Back 39

laminin

Front 40

lysyl oxidase role

Back 40

cross-links collagen to incr tensile strength

Front 41

important cofactor?

Back 41

Cu

Front 42

role of ascorbic acid

Back 42

hydroxylates proline, lysine

Front 43

Ehlers-Danlos is defect in which types of collagen

Back 43

I, III

Front 44

Zn role in collagen?

Back 44

Cofactor for collagenase

Front 45

Xs type III collagen forms

Back 45

keloid

Front 46

What 2 landmarks are seen in severe liver injury

Back 46

regenerative nodules, fibrosis

Front 47

Repair cell of the lung?

Back 47

type II pnemocyte

Front 48

brain injury causes proliferation of

Back 48

astrocytes, microglia

Front 49

Key cell in reinnervation peripherally

Back 49

Schwann cell

Front 50

What's the Schwann cell of the CNS?

Back 50

Oligodendrocyte

Front 51

Corticosteroids inc/dec which WBC?

Back 51

Inc: neutrophils; dec: lymphocytes, eosinophils

Front 52

What affect does rouleaux formation have on ESR?

Back 52

Inc

Front 53

What are 2 causes for rouleaux formation?

Back 53

Inc fibrinogen, anemia

Front 54

Serum protein electrophoresis results with acute infl? 2

Back 54

dec albumin, inc IgM

Front 55

Polyclonal gammopathy indicates

Back 55

chronic infl

Front 56

NK cells are which type of WBC

Back 56

lymphocytes!

Front 57

TLRs recognize

Back 57

non-self Ag on pathogens

Front 58

Vasc permeabilty causes? 2

Back 58

Dec oncontic pressure; hemostasis

Front 59

Master switch to the nucleus

Back 59

NFkB

Front 60

Endothelial retraction promoted by? 2

Back 60

IFN-γ, IL-1

Front 61

HLA system in located on which chr

Back 61

Chr 6

Front 62

Vasodilation causes? 2 Promoted by?

Back 62

Hyperemia; incr hydrostatic pressure

Front 63

HLA-B27 is associated with which dz

Back 63

ankylosing spondylitis

Front 64

Promoted by?

Back 64

Histamine

Front 65

HLA-D2 is associated with

Back 65

MS

Front 66

Edema is the result of which 2 forces?

Back 66

Hydrostatic pressure incr + oncotic pressure dec

Front 67

HLA-D3,4 is associate with

Back 67

T1DM

Front 68

Early phase of mast cells

Back 68

Degranulation

Front 69

Late phase of mast cells

Back 69

Production PG, LT

Front 70

Steps of extravasation? 7

Back 70

Rolling -> adhesion -> diapedesis -> chemotaxis -> phagocytosis -> engulfment -> killing

Front 71

Rolling proteins? 3

Back 71

Selectins, mucins, LAD-2

Front 72

Adhesion proteins? 3

Back 72

Ig, VCAM, ICAM, LAD-1

Front 73

Diapedesis proteins? 1

Back 73

PECAM

Front 74

Chemotaxis proteins? 4

Back 74

LPS, C5a, LTB4, IL-8

Front 75

Phagocytosis proteins? 5

Back 75

IgG, C3b, MBL, Fn, C-reactive

Front 76

Myasthenia gravis is which type of HSR

Back 76

Type II

Front 77

Grave's disease is which type of HSR

Back 77

Type II

Front 78

Arthrus rxn is which type of HSR

Back 78

Type III

Front 79

Contact dermatitis is which type of HSR

Back 79

Type IV

Front 80

Is hyperacute rejection reversible?

Back 80

NO

Front 81

Engulfment inhibited in which disease?

Back 81

Chediak-Higashi syndrome

Front 82

Is acute rejection reversible?

Back 82

Yes

Front 83

Killing requires? 6

Back 83

TNF-α, MBP, MPO, Defensin, lactoferrin, lysozyme

Front 84

Is chronic rejection reversible?

Back 84

No

Front 85

Defect causes which dz?

Back 85

Chronic granulomatous dz

Front 86

3 signs of GVHD?

Back 86

jaundice, diarrhea, dermatitis

Front 87

Role of TNF-alpha 4

Back 87

Activate endothelium
Cause leukocyte recruitment, vascular leak
Induces fever
Induce septic shock

Front 88

ANA are

Back 88

Ab against DNA, histone, acidic proteins, nucleoli

Front 89

Termination of acute infl by? 5

Back 89

LT -> lipoxin, resolvin, protectin, IL-10, TGF-β

Front 90

Anti-ds DNA seen in

Back 90

SLE with glomerulonephritis

Front 91

Apoptosis

Front 92

anti-histone Ab often in

Back 92

Drug-induced lupus

Front 93

Pro-apoptotic factors? 10

Back 93

Casp 3, granzyme, SMAC/DIABLO, perforin, fas, casp8, casp 9, p53, apaf-1, Bax

Front 94

2 anti-acidic Ab

Back 94

anti-Sm, anti-rnp

Front 95

Antiapoptotic factors? 5

Back 95

TNF, NFKB, IAPs, FLIP, BCL-2, Bax-BCL2 complex

Front 96

Systemic sclerosis has which 2 types of Ab

Back 96

anti-rnp, anti-nucleolar

Front 97

TNF pathway? 3

Back 97

TNF -> NFkB -> Bcl-2

Front 98

Rim pattern on ANA flourescent test assoc with

Back 98

anti-ds DNA

Front 99

p53 activates? 2

Back 99

Bax/Bcl -> cyt c

Front 100

Most common cardiac finding in SLE

Back 100

fibrinous pericarditis w/ effusion

Front 101

cyt c pathway? 4

Back 101

cyt c -> apoptosome -> activates casp 9 -> activates casp 3, 6, 7

Front 102

most common drug associate with drug-induced lupus

Back 102

procainamide

Front 103

executioner casp? 2

Back 103

casp 3, 6

Front 104

What is an LE cell?

Back 104

Neutrophil with phagocytosed altered DNA

Front 105

fasL pathway? 5

Back 105

fasL -> fas -> FADD -> casp 8 & 10 activation -> casp 3 activation

Front 106

Most common initial sign of SS?

Back 106

Raynauds

Front 107

FLIP inh?

Back 107

Casp 8 & 10 activation

Front 108

Most common cause of death in SS?

Back 108

Resp failure

Front 109

IAP inh?

Back 109

Casp 3 activation

Front 110

anti-topoisomerase is assoc with

Back 110

SS

Front 111

SMAC/DIABLO inh?

Back 111

IAPs

Front 112

What is CREST?

Back 112

Calcinosis/Centromere Ab, Raynauds, Esophageal dysmotility, Sclerodactyly, Telangiectasisas

Front 113

Bcl-2 inh?

Back 113

Cyp c

Front 114

Tx for SS?

Back 114

D-penicillamine

Front 115

epi for dermatomyositis/polymyositis

Back 115

F 40-60

Front 116

DM patho

Back 116

Ab-mediated

Front 117

PM patho

Back 117

T cell mediated

Front 118

Racoon eyes

Back 118

heliotrope eyelids; red-purple discoloration (DM or PM)

Front 119

purple patches over knuckles and PIPs

Back 119

Gottron's patches (DM or PM)

Front 120

DM/PM serum shows

Back 120

inc Cr

Front 121

MCTD definitely has Ab against

Back 121

ribonucleoprotein Ab

Front 122

most common congenital immunodef

Back 122

IgA def

Front 123

hereditary angioedema is a def in

Back 123

C1 esterase inh

Front 124

PNH is a def in

Back 124

Decay accelerating factor

Front 125

test indicating activation of classic comp sys 3

Back 125

dec C4, dec C3, norm factor B

Front 126

test indicating activation of alt comp sys 3

Back 126

dec factor B, dec C3, norm C4

Front 127

test indication activation of both classic & alt comp sys 3

Back 127

dec C3, C4, factor B

Front 128

apple green birefringenece in polarized light

Back 128

amyloid

Front 129

amyloid on H&E

Back 129

eosinophilic

Front 130

AL amyloid derived from

Back 130

amyloid light chain;

Front 131

AA amyloid dervied from

Back 131

serum amyloid (acute phase reactant)

Front 132

beta amyloid dervied from

Back 132

amyloid precursor protein (of Chr 21, Alz)

Front 133

systemic AL

Back 133

MM

Front 134

systemic AA

Back 134

chronic infl (RA, TB)

Front 135

hereditary amyloid disorder

Back 135

familial Mediterranena fever (AA)

Front 136

epi for dermatomyositis/polymyositis

Back 136

F 40-60

Front 137

DM patho

Back 137

Ab-mediated

Front 138

PM patho

Back 138

T cell mediated

Front 139

Racoon eyes

Back 139

heliotrope eyelids; red-purple discoloration (DM or PM)

Front 140

purple patches over knuckles and PIPs

Back 140

Gottron's patches (DM or PM)

Front 141

DM/PM serum shows

Back 141

inc Cr

Front 142

MCTD definitely has Ab against

Back 142

ribonucleoprotein Ab

Front 143

most common congenital immunodef

Back 143

IgA def

Front 144

hereditary angioedema is a def in

Back 144

C1 esterase inh

Front 145

PNH is a def in

Back 145

Decay accelerating factor

Front 146

test indicating activation of classic comp sys 3

Back 146

dec C4, dec C3, norm factor B

Front 147

test indicating activation of alt comp sys 3

Back 147

dec factor B, dec C3, norm C4

Front 148

test indication activation of both classic & alt comp sys 3

Back 148

dec C3, C4, factor B

Front 149

apple green birefringenece in polarized light

Back 149

amyloid

Front 150

amyloid on H&E

Back 150

eosinophilic

Front 151

AL amyloid derived from

Back 151

amyloid light chain;

Front 152

AA amyloid dervied from

Back 152

serum amyloid (acute phase reactant)

Front 153

beta amyloid dervied from

Back 153

amyloid precursor protein (of Chr 21, Alz)

Front 154

systemic AL

Back 154

MM

Front 155

systemic AA

Back 155

chronic infl (RA, TB)

Front 156

hereditary amyloid disorder

Back 156

familial Mediterranena fever (AA)