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57 Cards in this Set
- Front
- Back
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burkitss
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EBV, starry sky normal macrophages
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hodgkin's dz cardinal sign
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fever, night sweats, wt loss
Reed Steinberg cell, RS-owl eyes |
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nodular sclerosis
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lymph node involvement in neck and ant mediastinum
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chronic iflammation-antiboy
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IgG , eg, rheumatoid arthritis, crohns, Uc
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polyclonal gammopathy
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benign and chronic inflammation
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acute inflammation
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IgM (eg acute appendicits)
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monoclonal gammopathy
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malignancy, and always means multiple myeloma..
one clone of plasma making Igs most of the time IgG malignancy-making light chains and getting into urine-Bence Jines proteins |
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multiple myelomma
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plamsa cell disorder,
increase plasma cell no. |
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active cell in multiple myeloma
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plasma cells have IL-1(osteoclast activationg factor)
therefore lytic lesions in skull n bones(PUNCHED OUT APPEARNCE) pathologic bone fracture severe constant back and rib pain(early diagnostic sign) |
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summary of multiple myelomma
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lytic lesions
bence jines proteins seen in elderly patients |
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amylodoisis
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clinical characteristic of multiple myelomma
accumulation of abnormal fibrillar sceleroprotein - congo red stains amyloid - deposits of amyloid (amylin) in islet cell cause DM-2 |
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lysosomal storage dz
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gauchers dz- lysosomes filled wth glucocerebrosieds
niemann pick dz- sphingomyelin in lysosome pompe's dz- glycogen present |
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anticoagulants
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heparin-+ antithrombin III (made in liver)-inhibits serine proteases coagulation factor
PGI2, prostacyclin (frm endothelial cells)- VASODIALATOR Protein C and Protein S- vit k dependent factors-2,7,9,10; inhinit 5 and 8 |
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tissue plasminogen activating factor
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anticoagulant,
dissolve clot in coronary thrombosis |
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extrinsic factor in coagulation
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7
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instrinsic factor
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12, 11, 9 ,8
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bth share common pathway
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factor 10
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factor 2
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prothrombin
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factor 1
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fibrinogen
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prothrombin time
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frm exrinsic pathway to clot - 7, 10, 5 , 1, 2
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partial prothrombin
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from intrinsic pathway to clot- 12, 11, 9, 8, 10, 5 , 2 ,1
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hemophillia 8
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factor 8 def
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factor 13
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fibrin stabilizing factor,
makes the clot stonger by putting cross bridge in fibrin |
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idiopathic thrombocytopenic purpura
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petechai
platelet count decrease IgG againd platelet - type II hypn- removed by macrophage in spleen. |
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thrombotic thrombocytopenic purpura n hemolkytic uremic syndrome
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low platelet count
inc bleeding time pt and ptt normal |
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platelet abnormalities
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increase bleeding time
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coagualtion deficiency
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delayed bleeding
hemophillia A vWBDz |
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vWBDz
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defect in adhesion factor
mild factor deficieny 8 gi bleeding menorrhagia history of epistaxis, bruise |
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hemophillia A
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factor 8 def
x linked recessive dz |
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anticardiolipin ab
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feature of lupus
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lupus anticoagulant
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thrombogenic.
anticardiolipin also thrombogenic |
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clotting all over body within vessels
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DIC
therefore coagulation factor def |
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features of dic
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thrombi in vessels
anticoagulated as all cog factors and platelet consumed |
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hemorrhagic thrombosis syndrome
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aka DIC
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MCC DIC
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septic shock, snake bite, ARDS
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classic DIC
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platelet count decreased
ptt and PT prolonged |
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thrombogenic
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blood control pills as they have estrogen-increase factor 5 and 8
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increase in clot
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thrombogenic
def of anticoagulanst |
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pt has hemophilia A, factor 8 def, bleeding time normal why?
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bleeding time has nthng to do wth COAGULATION FACTOR,
purely platelet dependent |
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increased bleeding time
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thrombocytopenia
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platelet adhesion defect
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vWBDz- increased bleeding time
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MCC of prolonged bleeding time
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aspirin-inhibits platelet frm aggregating, therefore no TxA2
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blood group O
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have anti A IgM, anti B-IgM, anti AB IgG
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blood group A
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anti B IgM
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blood group B
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anti A IgM
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AB
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nothing
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type II hypn
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hemolytic anemia and thrombocytopenic purpura
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type I hypn
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Pencillin rash
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most common Ab in USa
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CMV
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MC infection transmitted by blood transfusion
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CMV
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MCC post transfusion hepatitis
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hep c
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accidental needle stick frm pt, MC infection
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hep B
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most imp cause fr secondary hypertension
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renal dz, therefor renin angiotensis system.
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one of the imp diagnostic sign fr high bp
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retinal hemorrhage
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eclampsia
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preclampsia and seizures
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endocarditis
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most comon valve- mitral valve
2nd mc: tricuspid |
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intravenous drug user-endocarditis
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mc valve tricuspid
mcc: stap aureus |
