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22 Cards in this Set
- Front
- Back
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What is the common name for Type III HSN?
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Immune complex disease
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What are the steps in Type III HSN?
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1. Antigen introduced
2. Cells make Ab against it 3. Ag-Ab reaction in bloodstream 4. Immune complexes form |
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What are the 2 bad effects of immune complexes forming?
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1. Complement activation resulting in tissue dmg/fever
2. Deposition in small vessels |
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What are the 3 common manifestations of immune complex deposition in small vessels?
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1. Vasculitis
2. Arthritis 3. Glomerulonephritis |
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What are 2 things that immune complex deposition depends on?
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1. The size of the immune complex
2. The dose of antigen |
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What immune complexes are easier to remove from circulation?
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Larger
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What are the most pathogenic immune complexes? (size/dose)
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-Small to intermediate sized
-Slight antigen excess |
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What are 6 common sites of immune complex deposition?
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1. Glomeruli
2. Skin 3. Serosal surfaces 4. Small blood vessels 5. Joints 6. Heart |
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What are 7 type III hsn diseases?
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SPPARAS
Systemic lupus erythematosus Poststrep glomerulonephritis Polyarteritis nodosa Acute glomerulonephritis Reactive arthritis Arthus reaction Serum sickness |
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What antigens are involved in SLE and what are the clinical manifestations?
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Anti-dsDNA, Anti-Sm
Nephritis, arthritis, vasculitis |
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What antigens are involved in Poststrep glomerulonephritis and what are the clinical manifestations?
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-Anti-strep cell wall antibody
-Nephritis |
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What antigens are involved in Polyarteritis nodosa and what are the clinical manifestations?
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-Anti Hep B surface antigen
-Vasculitis |
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What antigens are involved in Acute Glomerulonephritis and what are the clinical manifestations?
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-Bacterial, parasitic, or tumor antibodies
-Nephritis |
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What antigens are involved in Reactive arthritis and what are the clinical manifestations?
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Anti-bacteria, yersinia
Acute arthritis |
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What antigens are involved in Arthus reaction and what are the clinical manifestations?
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A variety of antigens
Cutaneous vasculitis |
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What antigens are involved in Serum sickness and what are the clinical manifestations?
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Foreign serum
Nephritis, arthritis, and vasculitis. |
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What is the most common cause of serum sickness today? What is the treatment?
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Penicillin/antibiotic treatment
Corticosteroids are treatment |
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What is Type IV Hsn?
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Cell-mediated
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What is type IV hsn the major reaction pattern against?
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Intracellular pathogens
-mycobacteria -fungi -parasites |
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What are the 2 common examples of Type IV hsn?
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-Tuberculin skin test
-Contact dermatitis |
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What are the 2 mechanisms of CTL mediated cytotoxicity?
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-Fas/FasL interaction
-Granzyme/perforin mediated |
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What type of hypersensitivity is Drug-induced hemolytic anemia?
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type II
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