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22 Cards in this Set

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What is the common name for Type III HSN?
Immune complex disease
What are the steps in Type III HSN?
1. Antigen introduced
2. Cells make Ab against it
3. Ag-Ab reaction in bloodstream
4. Immune complexes form
What are the 2 bad effects of immune complexes forming?
1. Complement activation resulting in tissue dmg/fever
2. Deposition in small vessels
What are the 3 common manifestations of immune complex deposition in small vessels?
1. Vasculitis
2. Arthritis
3. Glomerulonephritis
What are 2 things that immune complex deposition depends on?
1. The size of the immune complex
2. The dose of antigen
What immune complexes are easier to remove from circulation?
Larger
What are the most pathogenic immune complexes? (size/dose)
-Small to intermediate sized
-Slight antigen excess
What are 6 common sites of immune complex deposition?
1. Glomeruli
2. Skin
3. Serosal surfaces
4. Small blood vessels
5. Joints
6. Heart
What are 7 type III hsn diseases?
SPPARAS
Systemic lupus erythematosus
Poststrep glomerulonephritis
Polyarteritis nodosa
Acute glomerulonephritis
Reactive arthritis
Arthus reaction
Serum sickness
What antigens are involved in SLE and what are the clinical manifestations?
Anti-dsDNA, Anti-Sm
Nephritis, arthritis, vasculitis
What antigens are involved in Poststrep glomerulonephritis and what are the clinical manifestations?
-Anti-strep cell wall antibody
-Nephritis
What antigens are involved in Polyarteritis nodosa and what are the clinical manifestations?
-Anti Hep B surface antigen
-Vasculitis
What antigens are involved in Acute Glomerulonephritis and what are the clinical manifestations?
-Bacterial, parasitic, or tumor antibodies
-Nephritis
What antigens are involved in Reactive arthritis and what are the clinical manifestations?
Anti-bacteria, yersinia
Acute arthritis
What antigens are involved in Arthus reaction and what are the clinical manifestations?
A variety of antigens
Cutaneous vasculitis
What antigens are involved in Serum sickness and what are the clinical manifestations?
Foreign serum
Nephritis, arthritis, and vasculitis.
What is the most common cause of serum sickness today? What is the treatment?
Penicillin/antibiotic treatment
Corticosteroids are treatment
What is Type IV Hsn?
Cell-mediated
What is type IV hsn the major reaction pattern against?
Intracellular pathogens
-mycobacteria
-fungi
-parasites
What are the 2 common examples of Type IV hsn?
-Tuberculin skin test
-Contact dermatitis
What are the 2 mechanisms of CTL mediated cytotoxicity?
-Fas/FasL interaction
-Granzyme/perforin mediated
What type of hypersensitivity is Drug-induced hemolytic anemia?
type II