Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
59 Cards in this Set
- Front
- Back
|
MYC translocation
|
8:14
|
|
|
BCR-ABL translocation
|
9:22
|
|
|
Ewing sarcoma translocation
|
11:22
|
|
|
T-cell ALL Translocation
|
8:14
10:14 |
|
|
What chromosome is the Ig gene on?
|
Chromosome 14
|
|
|
Mantle cell lymphoma translocation
|
11:14
|
|
|
Follicular lymphoma translocation
|
14:18
|
|
|
AML/ALL translocation
|
4:11
6:11 |
|
|
HCG marker
|
Trophoblastic tumor
Nonseminomatous testicular tumor |
|
|
Calcitonin marker
|
Medullary CA of thyroid
|
|
|
Catecholamine and metabolite tumor marker
|
Pheochromocytoma
|
|
|
Alpha fetoprotein tumor marker
|
HCCA
Nonseminomatous testicular cancer/germ cell cancers |
|
|
Carcinoembryonic antigen (CEA)
|
Colon
Pancreas Lung Stomach Breast |
|
|
Name two oncofetal antigens
|
Alpha fetoprotein
Carcinoembryonic antigen |
|
|
Markers for prostate cancer
|
PSA (prostate specific antigen)
Prostatic acid phosphatase CA 19-9 |
|
|
Neuron specific enolase (NSE) antigen
|
Small cell CA of lung
Neuroblastoma |
|
|
Immunoglobulin tumor markers
|
Multiple myeloma
Other plasma cell lesions |
|
|
CA-125 mucin tumor marker
|
Ovarian cancer
|
|
|
CA-19-9 mucin tumor marker
|
Colon cancer
Pancreatic cancer |
|
|
CA-15-3 mucin tumor marker
|
Breast cancer
|
|
|
Cushing syndrome: mechanism
|
Ectopic production of ACTH or ACTH-like substances
|
|
|
Cushing syndrome: underlying neoplasm
|
SCCA of lung
Thymoma Pancreatic cancer Neural tumor |
|
|
Hypercalcemia: mechanism
|
Osteolysis (not PNS)
ectopic production of PTH or PTH related IL-1, TGF-alpha, TNF, Vit D |
|
|
Hypercalcemia: underlying neoplasm
|
SCCA of lung
Lymphoma Breast cancer Kidney cancer Uterine cervical cancer Ovarian cancer |
|
|
Hyponatremia: mechanism
|
Ectopic production of ADH or atrial natriuretic hormone
|
|
|
Hypoatremia: underlying neoplasm
|
SCCA of lung
Intracranial neoplasm |
|
|
Hypoglycemia: mechanism
|
Ectopic secretion of insulin or insulin-like factors
|
|
|
Hypoglycemia: underlying neoplasm
|
Large sarcomata
HCCA |
|
|
Marker phenotype: intestinal adenomata
|
Familial adenomatous polyposis
|
|
|
Marker phenotype: benign neoplasms
|
Multiple endocrine neoplasia (MEN)
|
|
|
Carcinoid syndrome: mechanism
|
Release of seratonin, bradykinin, histamine
|
|
|
Carcinoid syndrome: underlying neoplasm
|
Carcinoid tumor (gut, lung)
|
|
|
Polycythemia: mechanism
|
Erythropoietin
|
|
|
Polycythemia: underlying neoplasm
|
RCCA
HCCA Cerebellar hemangioma |
|
|
Myasthenia: underlying neoplasm
|
Small cell CA of lung
Other lung CA Thymoma |
|
|
CNS white matter degeneration: underlying neoplasm
|
Lymphoma
|
|
|
Peripheral neuropathy: underlying neoplasm
|
Lung CA
Breast CA |
|
|
Acanthosis nigricans: underlying neoplasm
|
Lung CA
Stomach CA Uterus CA Breast CA |
|
|
Dermatomyositis: underlying neoplasm
|
Lung CA
Breast CA Gut CA |
|
|
Hypertrophic osteoartropathy: mechanism
|
Unknown
|
|
|
Hypertrophic osteoarthropathy: underlying neoplasm
|
Lung CA
|
|
|
Migratory thrombophlebitis: mechanism
|
Mucin activating coagulation cascade
|
|
|
Migratory thrombophlebitis: underlying neoplasm
|
Pancreas CA
Other mucinous CA |
|
|
Nonbacterial thrombotic endocarditis: Mechanism
|
Hypercoagulability
|
|
|
Anemia: underlying neoplasm
|
Thymoma
CLL Lymphoma |
|
|
Thrombocythemia: underlying neoplasm
|
Various carcinomas
Lymphoma Thymoma |
|
|
Granulocytosis: underlying neoplasm
|
Thymoma
|
|
|
Eosinophilia: underlying neoplasm
|
Hodgkin disease
T-cell lymphoma |
|
|
Nephrotic syndrome: underlying neoplasm
|
Many
|
|
|
Nephrotic syndrome: mechanism
|
Tumor antigens
|
|
|
Immune complex glomerulonephritis: underlying neoplasm
|
Many
|
|
|
Immune complex glomerulonephritis: mechanism
|
Immune complexes
|
|
|
Red cell aplasia is associated with what cancer?
|
Thymoma
|
|
|
Hemolytic anemia is associated with what cancer?
|
CLL
Lymphoma |
|
|
What is nonbacterial thrombotic endocarditis?
|
aka marantic endocarditis
Fibrin accumulates on cardiac valves (L>R) and can embolize |
|
|
Chromosome abnormality found in sarcoma?
|
Translocation of 12:16
|
|
|
In what types of cancers is the APC gene mutation seen?
|
Colon/gastric
Esophageal |
|
|
What is the most commonly mutated proto-oncogene?
|
RAS gene
|
|
|
What is the most commonly mutated gene in cancer?
|
p53
|
