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44 Cards in this Set

  • Front
  • Back
two things "round up" endothelium
histamine
LTC4, LTD4, LTE4 act synergistically with LTB4
ultimate mediator of vascular tone?
NO
Heparin: polysaccharide or polypeptide?
heparin=polysaccharide
kinin: polysaccharide or polypeptide?
kinin: polypeptide
Factor 12 activated?
pre-kallikreins
Activates the LT cascade and is activated when cytosolic Ca levels are elevated.
-Lipooxygenase
chemotactic for neutrophils?
LTB4
which LT promotes the respiratory burst?
-LTB4
which LT(s) increase capillary permeability?
-LTC4, LTD4, LTE4 with LTB4
two lipoxins?
-LXA4, LXB4
What do lipoxins (LXA4 and LXB4) do?
anti-inflammatory
stimulation of acute phase proteins in the liver by?
IL-1
IL-6
TNF alpha
where are complement proteins mostly made?
liver
complement self assemble to form?
-lytic complex=poke holes (type II hypersensitivity does a lot of lysing)
anaphylotoxins?
C5a, C3a
what acts as an opsonin?
-C3b
a chemoattractant?
-C5a
What C fragment is a powerful attractant for neutrophils?
C3
what inactivates complement?
carboxypeptidase
what ultimately takes up Fe-lactoferrin?
-macrophages
assoc with "anemia of chronic disease"
hepcidin
What to know about interferons alpha and beta?
activated by viruses and attack viruses
most important mediator for activating macrophages?
IFN gamma
IL-1 does what to the endothelium?
makes it sticky for adhesion
IL enhances the activity of cytotoxic T cells and NK cells
IL-2 and IL-15
IL that is a potent hematopoiten and stimulates mature mast cells and macrophages to divide and prevent them from dying prematurely
IL-3
work synergistic with IL 10
IL-4 and IL13
IL that stimulates eosinophils
IL-5
IL most important for stimulating hepatocytes to generate acute phase proteins and stimulating IgA
IL-6
major inhibitory IL in inflammation
IL-10
IL that stimulates cell mediated immunity
IL-12
Cachectin, lymphotoxin aka?
TNF alpha and TNF beta
neutrophil migration IL?
IL-8
long range chemotactic mediators for neutrophils
IL-8
LTB4
PAF
short range chemotactic mediators for neutrophils
C5a, C3a
formyl peptides
process essential for neutrophil function?
respiratory burst
granules that contain myeloperoxidase?
azurophil granules
collagenase and gelatinase from what cell and do what?
from neutrophil
destroy the stromal framework which supports the tissue parenchyma
NETs?
Neutrophil Extracellular Traps
have metachromatic granules?
-mast cells and basophils
who becomes a histiocyte?
monocytes
have a good free radical generating system and undergo a "respiratory burst" similar to that of granulocytes
lymphocytes
without __________ macrophages are not able to kill certain bacterial or protozoal organisms
Nramp1
levels of a wound?
1. zone of mature connective tissue
2. zone of capillary proliferation
3. zone of capillary arches and sprouts
4. zone of necrotic debris