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44 Cards in this Set
- Front
- Back
two things "round up" endothelium
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histamine
LTC4, LTD4, LTE4 act synergistically with LTB4 |
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ultimate mediator of vascular tone?
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NO
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Heparin: polysaccharide or polypeptide?
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heparin=polysaccharide
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kinin: polysaccharide or polypeptide?
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kinin: polypeptide
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Factor 12 activated?
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pre-kallikreins
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Activates the LT cascade and is activated when cytosolic Ca levels are elevated.
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-Lipooxygenase
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chemotactic for neutrophils?
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LTB4
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which LT promotes the respiratory burst?
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-LTB4
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which LT(s) increase capillary permeability?
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-LTC4, LTD4, LTE4 with LTB4
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two lipoxins?
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-LXA4, LXB4
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What do lipoxins (LXA4 and LXB4) do?
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anti-inflammatory
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stimulation of acute phase proteins in the liver by?
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IL-1
IL-6 TNF alpha |
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where are complement proteins mostly made?
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liver
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complement self assemble to form?
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-lytic complex=poke holes (type II hypersensitivity does a lot of lysing)
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anaphylotoxins?
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C5a, C3a
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what acts as an opsonin?
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-C3b
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a chemoattractant?
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-C5a
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What C fragment is a powerful attractant for neutrophils?
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C3
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what inactivates complement?
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carboxypeptidase
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what ultimately takes up Fe-lactoferrin?
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-macrophages
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assoc with "anemia of chronic disease"
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hepcidin
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What to know about interferons alpha and beta?
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activated by viruses and attack viruses
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most important mediator for activating macrophages?
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IFN gamma
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IL-1 does what to the endothelium?
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makes it sticky for adhesion
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IL enhances the activity of cytotoxic T cells and NK cells
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IL-2 and IL-15
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IL that is a potent hematopoiten and stimulates mature mast cells and macrophages to divide and prevent them from dying prematurely
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IL-3
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work synergistic with IL 10
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IL-4 and IL13
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IL that stimulates eosinophils
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IL-5
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IL most important for stimulating hepatocytes to generate acute phase proteins and stimulating IgA
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IL-6
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major inhibitory IL in inflammation
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IL-10
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IL that stimulates cell mediated immunity
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IL-12
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Cachectin, lymphotoxin aka?
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TNF alpha and TNF beta
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neutrophil migration IL?
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IL-8
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long range chemotactic mediators for neutrophils
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IL-8
LTB4 PAF |
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short range chemotactic mediators for neutrophils
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C5a, C3a
formyl peptides |
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process essential for neutrophil function?
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respiratory burst
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granules that contain myeloperoxidase?
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azurophil granules
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collagenase and gelatinase from what cell and do what?
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from neutrophil
destroy the stromal framework which supports the tissue parenchyma |
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NETs?
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Neutrophil Extracellular Traps
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have metachromatic granules?
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-mast cells and basophils
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who becomes a histiocyte?
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monocytes
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have a good free radical generating system and undergo a "respiratory burst" similar to that of granulocytes
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lymphocytes
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without __________ macrophages are not able to kill certain bacterial or protozoal organisms
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Nramp1
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levels of a wound?
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1. zone of mature connective tissue
2. zone of capillary proliferation 3. zone of capillary arches and sprouts 4. zone of necrotic debris |