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19 Cards in this Set
- Front
- Back
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What is the primary disease that causes "Nodular Glomerulosclerosis"?
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Diabetic Glomerulopathy
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Which form of diabetes is associated w/ Diabetic Glomerulopathy?
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Both forms;
Type 1 > Type 2 |
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Diabetic Glomerulopathy is the most common cause of what illness in the US?
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Chronic Renal Failure
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What are the primary risk factors for diabetic glomerulopathy?
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Poor Diet/Glycemic Control
Hypertension |
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What is a physical exam finding that highly correlated with Diabetic Glomerulopathy? (Hint: It doesn't have anything to do directly with your kidneys)
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Diabetic Retinopathy
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What is the principle mechanism of pathogenesis in Diabetic Glomerulopathy?
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Non-enzymatic Glycosylation of glomerulus (and even tubule)
Glucose attaches to amino acids Increases permeability to proteins |
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Which of the renal vessels is affected first by Diabetic Glomerulopathy? What is this process called? What does this do to the GFR?
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Efferent Arteriole
Hyaline Arteriosclerosis Decreases GFR |
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What is a diagnostic microscopic finding of Diabetic Glomerlopathy?
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Kimmelstiel-Wilson Nodules
Proteins and Type IV collagen trapped in the mesangial matrix |
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What is seen on electron microscopy of Diabetic Glomerulopathy?
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Fusion of podocytes
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What is the initial laboratory finding that indicates Diabetic Glomerulopathy? When during the course of diabetes does this begin to manifest?
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Microalbuminuria
~10 years after poor glycemic control |
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What is the main pharmacologic treatment for Diabetic Glomerulopathy?
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ACEI - decreases ACE constriction of efferent arterioles
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What is the inheritence pattern of Alport's Disease?
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Autosomal Dominant (perhaps X-linked?)
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What is the pathogenic mechanism of Alport's Disease?
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Auto-antibodies developed to type IV collagen in GBM (sounds like Goodpastures?)
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What other defecits are associated with the genetic Alport's Syndrome?
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Sensorineural hearing loss and abnormal ocular movements
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What are the miscroscopic finding of Alport's Disease?
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Lipid accumulation in VECs producing foams cells
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What is the inheritance pattern of Thin Basement Membrane Disease?
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Autosomal Dominant
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What happens to renal function in Thin Basement Membrane Disease?
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Normal Function - mild proteinuria, constant hematuria
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List from most common to least the causes of Chronic Glomerulonephritis?
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1. RPGN
2. FSGS 3. Type 1 MPGN 4. Membranous GN 5. Diffuse Prol. GN (SLE) 6. IgA GN |
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What is the gross appearance of the kidneys in Chronic Glomerulonephritis?
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Shrunken Kidneys
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