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23 Cards in this Set
- Front
- Back
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Lumpy-bumpy =
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Acute proliferative GN
(poststeptococcal) |
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What is the crescent from Cr-GN made of?
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Fibrin
Macrophages, monocytes Parietal cells of BC |
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Cr-GN with (+) anti=GM Ab's and Linear deposits of IgG and C3
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Type I
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Cr-GN with "lumpy bumpy" IF, and post-streptococcal,SLE, IgA Nephropathy, or Henoch schonlein
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Type II
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Cr-GN with (-) anti-GBM, (-) IC's, (+) ANCA and Wegeners granulomatosis
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Type III
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Elevated ASO titers, LOW serum complement =
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Acute post-streptococcal GN
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Types of Nephritic Syndrome
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Acute prolif/poststrep GN
anti-GBM disease/Goodpastures RPGN IgA Nephropathy Membranoproliferative GN Alport's |
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Anti-GBM Disease with pulmonary involvement =
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Goodpasture's
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Berger's =
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IgA Nephropathy
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MCC of GN in the World
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IgA Nephropathy (Berger's)
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Hallmark of IgA nephropathy
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IgA deposition in the mesangium
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IgA nephropathy may be a variant of -
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Henoch-Schonlein purpura
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Difference betw. Henoch and IgA
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IgA is only kidney involvement.
Henoch is systemic. Both have IgA deposits |
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In IgA nephropathy, where are the deposits?
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in the MESANGIUM
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What conditions are IgA nephropathy associated with?
And Why? |
Celiac Sprue (intestinal mucosal defects)
Liver disease (defective hepatobiliary clearance of IgA) Henoch-shonlein |
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Recurrent hematuria during/after URI =
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IgA Nephropathy
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Nephritis + Deafness + Eye disorders (lens dislocation, posterior cataracts, corneal dystrophy)
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Alport's
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BM show foci of thickening w/ splitting and lamination of lamina densa, basket weave appearance
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Alport's
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Which gene is mutated in Alport's? and what protein does that gene encode?
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Gene: COL4A5
Alpha 5 chain of collagen Type 4 |
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MCC of nephrotic syndrome in children
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Minimal change disease
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Disease with Nephrotic syndrome
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Membranous GN, Minimal Change disease, Focal segmental, membranoproliferative
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(+) C3 nephritic factor
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Type 2 MPGN
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Splitting of BM (tram tracking) on PAS or silver stain
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Membranoproliferative GN
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