Path: Inflammation

Front 1

COX

Back 1

Cyclooxygenase

Arachidionic Acid ----(COX)---> prostoglandins

Front 2

5-Lipoxygenase

Back 2

Arachidionic Acid ----(5-LO)--->Leukotrienes

Front 3

Activated Hageman Factors

Back 3

XII a (Coagulation Pathway)

-->intrinsic coagulation
-->prekalikrien activation
--> plasminogen activation (degrade fibrin clot)

Front 4

Thrombin Activity

Back 4

-fibrinogen cleavage

-plasminogen activation (will in turn activate C5)

-complement activation (C5)

-platelet activation

-endothelial cell activation via protease rec.

-protease activated receptors

Front 5

Platelet Activating Factor

Back 5

-vasoactive

-chemotaxis

-platelet activation

-pain

-endothelial cell activation

-leukocyte activation

-cell adhesion molecule

Front 6

Complement factor interacting with B-Cell CD21

Back 6

CD3d

potent opsonin

Front 7

Juxtacrine

Back 7

cells signal each other/ activate via touching

Front 8

Kallikrien-Kinin Pathway

Back 8

XIIa--->Prekallirien

PreKalikrien---> Kalikrien

Kalikrien ---> Bradykinin / Kinin

Front 9

Bradykinin Activities

Back 9

-vasodialation

-vascular permeability

-pain

-endothelial cell activation

Front 10

C2-Kinin

Back 10

vasoactive

Front 11

C3a, C5a

Back 11

anaphylotoxins

vasoactive, mast cell/platelet dependent

Front 12

C3b, C3bi

Back 12

opsonins

facilitate leukocyte phagocytosis

Front 13

C3d

Back 13

antigen-induced B-Cell activation

Front 14

C5a

Back 14

chemotactic factor

also an anaphylotoxin

Front 15

C5b-9

Back 15

membrane attack complex
(cytolysis)

Front 16

Kalikrien Activity

Back 16

intrinsic coagulation activation

kininogen cleavage

complement activation

Front 17

Hypergalesia

Back 17

"pain"

exacerbated by PGA E2

Front 18

Pyrexia

Back 18

heat / fever

Front 19

Rubor

Back 19

redness

Front 20

C5a, C5b67

Back 20

leukotactic

C5a = anaphylotactic

Front 21

Plasmin Activity

Back 21

fibrin clot lysis

C3 complement activation

Front 22

LTB4

Back 22

LTB4 Chemotactic
Leukocyte activation

Front 23

5-HETE
5-KETE

Back 23

Chemotactic

Front 24

LTC4
LTD4
LTE4

Back 24

increase Vascular permeability
increase Bronchoconstriction

Front 25

PGI2

Back 25

PGI2 Vasodilation, ↑cAMP
Platelet aggregation

Front 26

TXA2

Back 26

TXA2 Vasoconstriction
Platelet aggregation

Front 27

PGE2

Back 27

PGE2 Vasodilation, Hyperalgesia
Fever, Potentiates edema

Front 28

PGD2
PGF2a

Back 28

Vasodilation
Potentiates edema

Front 29

NSAID MOA

Back 29

blocks COX

blocks formation of prostaglandins

shifts over to leukotrienes

DO NOT GIVE TO ASTHAMATICS

Front 30

Zyflo MOA

Back 30

blocks 5-lipooxygenase

blocks formation of leukotrienes

good for asthamtics

Front 31

Corticosteroids MOA

Back 31

blocks activity of PLA2

cannot form ARACHIDIONIC ACID

cannot make PGAs and leukotrienes

decrease inflammation

Front 32

Platelet Activating Factor
(activity)

Back 32

Vasoactive (erythema, edema)

Chemotaxis

Platelet activation

Leukocyte stimulation

Endothelial cell activation

Cell adhesion molecule

Pain

Front 33

NO made by

Back 33

-endothelial cells
(stimulated by bradykinin)

-NO will increase cGMP

Front 34

IKB

Back 34

inhibitor of kappa-beta

inhibits TF NF-KB

corticosteroids will increase IKB

Front 35

CAMS

Back 35

endothelial cells bind to adhesins on WBC

Front 36

Where WBC margination, rolling, stopping, and diapedesis occurs:

Back 36

ARTERIOLES: rolling and adherance

CAPILLARIES: stopping

VENULES: diapedesis

Front 37

PECAM-1

Back 37

modulates endothelial migration of leukocytes

Front 38

Juxtacrine

Back 38

cells signal each other via touching surfaces

Front 39

Prostoglandin E2

Back 39

sensitizes specialized nerve endings to the effects of bradykinin

Front 40

Bradykinin

Back 40

-vasodilation
-increased vascular permability
-endothelial cell stimulation
-pain

Front 41

Kallikrien

Back 41

-intrinsic coagulation activation
-kinogen cleavage
-complement activation