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27 Cards in this Set

  • Front
  • Back
Kawasaki Dz S/Sx
Rash on palms/soles & lips/mouth, edematous hands, long duration fever
Kawasaki Dz complications
CAD (aneurysms), MI
Paraneoplastic pemphigus S/Sx
Cutaneous blisters, mucousal blisters (mouth, esophageal & lung), dyspnea [at later stages]
Pemphigus Vulgaris S/Sx
Blisters on skin & in mouth, painful but not itchy, hyperpigmentation after lesion resolution
Pemphigus epidemiology
mostly mid-life to elderly
Pemphigus foliaceus S/Sx
Blisters begin on scalp & face then chest/back, itchy but not painful. no mucous membrane blisters
Pemphigus foliaceus etiology
Desmogleyin-1 (DSG-1) Ab (no DSG-3 Ab), may be thio-drug triggered (thiols: penicillamine, captopril, piroxicam)
Pemphigus vulgaris etiology
Demoglein 3 (DSG-3) Ab
Standard Hodgkins Tx
ABVD
Standard non-Hodgkins Tx
CHOP-R [Cyclophosphamide, HydroxyDoxorubicin, Oncovin (Vincristine), Prednisone, - Rituximab]
Heparin-induced Thrombocytopenia complications
DVT, PE, or Ischemic stroke [platelets only fall around 40-60k, bleeding usually not an issue, clotting is!]
HUS etiology
Shiga-toxin from E coli O157:H7 or Shigella, usually in kids
HUS complications
Renal failure (occ fatal or permanent), Seizures, Cortical Blindness, Colon perf/ischemia
TTP Tx
Plasmapheresis, corticosteroids, and support [Platelet transfusion may cause ARF, seizures, death]
HUS Tx
Supportive! Dialysis often needed for ARF and HTN
Thrombocytopenia Tx with platelets?
< 50k before Sx, or < 10k, or refractory bleeding. [Extra caution in TTP/HUS which Tx may cause ARF, seizures, death]
TTP etiology
ADAMTS13 defn or Ab to ADAMTS13 AND stress of medication, dz, or infection
Differentiation of TTP from HUS
TTP more neuro effects, HUS more renal effects [but not always clear, sometimes considered the same entitiy]
Differentiation of ITP from TTP/HUS
ITP is chronic, TTP/HUS is acute
Drugs that may cause acute TTP
Quinine drugs, immunosuppressants, OCP
Medical conditions that may cause acute TTP
HIV, pregnancy, pancreatitis
TTP S/Sx
Fever, Anemia, Thrombocytopenia, Renal dysfunction, Neuro stuff [FAT RN!]
HSR1 etiology
IgE, histamine
HSR2 etiology
Auto-Antibodies
HSR3 etiology
Immune complex clumps
HSR4 etiology
Delayed reaction T-cell mediated
HSR4 examples
Skin reactions, MS, chronic graft rejection