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27 Cards in this Set
- Front
- Back
Kawasaki Dz S/Sx
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Rash on palms/soles & lips/mouth, edematous hands, long duration fever
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Kawasaki Dz complications
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CAD (aneurysms), MI
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Paraneoplastic pemphigus S/Sx
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Cutaneous blisters, mucousal blisters (mouth, esophageal & lung), dyspnea [at later stages]
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Pemphigus Vulgaris S/Sx
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Blisters on skin & in mouth, painful but not itchy, hyperpigmentation after lesion resolution
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Pemphigus epidemiology
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mostly mid-life to elderly
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Pemphigus foliaceus S/Sx
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Blisters begin on scalp & face then chest/back, itchy but not painful. no mucous membrane blisters
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Pemphigus foliaceus etiology
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Desmogleyin-1 (DSG-1) Ab (no DSG-3 Ab), may be thio-drug triggered (thiols: penicillamine, captopril, piroxicam)
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Pemphigus vulgaris etiology
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Demoglein 3 (DSG-3) Ab
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Standard Hodgkins Tx
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ABVD
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Standard non-Hodgkins Tx
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CHOP-R [Cyclophosphamide, HydroxyDoxorubicin, Oncovin (Vincristine), Prednisone, - Rituximab]
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Heparin-induced Thrombocytopenia complications
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DVT, PE, or Ischemic stroke [platelets only fall around 40-60k, bleeding usually not an issue, clotting is!]
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HUS etiology
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Shiga-toxin from E coli O157:H7 or Shigella, usually in kids
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HUS complications
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Renal failure (occ fatal or permanent), Seizures, Cortical Blindness, Colon perf/ischemia
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TTP Tx
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Plasmapheresis, corticosteroids, and support [Platelet transfusion may cause ARF, seizures, death]
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HUS Tx
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Supportive! Dialysis often needed for ARF and HTN
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Thrombocytopenia Tx with platelets?
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< 50k before Sx, or < 10k, or refractory bleeding. [Extra caution in TTP/HUS which Tx may cause ARF, seizures, death]
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TTP etiology
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ADAMTS13 defn or Ab to ADAMTS13 AND stress of medication, dz, or infection
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Differentiation of TTP from HUS
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TTP more neuro effects, HUS more renal effects [but not always clear, sometimes considered the same entitiy]
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Differentiation of ITP from TTP/HUS
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ITP is chronic, TTP/HUS is acute
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Drugs that may cause acute TTP
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Quinine drugs, immunosuppressants, OCP
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Medical conditions that may cause acute TTP
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HIV, pregnancy, pancreatitis
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TTP S/Sx
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Fever, Anemia, Thrombocytopenia, Renal dysfunction, Neuro stuff [FAT RN!]
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HSR1 etiology
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IgE, histamine
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HSR2 etiology
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Auto-Antibodies
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HSR3 etiology
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Immune complex clumps
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HSR4 etiology
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Delayed reaction T-cell mediated
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HSR4 examples
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Skin reactions, MS, chronic graft rejection
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