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15 Cards in this Set

  • Front
  • Back
pemphigus: defn
IgG against desmosomes of squamous epithelial cells
weak cell-celladherence with friction
blistering disease of skin and mucosa
what is the most common type of pemphigus?
pemphigus vulgaris (80%)
who gets pemphigus vulgaris and where?
30-50yo (4-6th decades)
points of pressure; scalp, face, axilla, groin, trunk
lesions in pemphigus vulgaris
inital oral ulcers
primary lesions-superficial vesicles and bullae
easily rupture->shallow erosion with dried serum crust
histopathology pemphigus vulgaris
suprabasal acantholysis (loss of intercell adhesion)
intraepidermal blister
"tombstone" layer of basal cells form floor of blister
inflamm below blister
direct immunoflourescence in pemphigus vulgaris
IgG deposits along PM of keratinocytes-> fishnet pattern
bullous pemphigoid:defn (who)
relatively common autoimmune, vesiculobullous disease
IgG against BM (Ag assoc with hemidesmosomes)
lesions bullous pemphigoid
resemble friction blister
clear fluid
<2cm (smaller than pemphigus)
resist rupture
inner thigh,flexor surface of arm, axilla
histopathology bullous pemphigoid
subepidermal blister (epidermis normal)
basal cell layer vacuolization-> blister
superficial dermal edema
direct immunoflourescence: bullous pemphigoid
linear deposition of C' at dermoepidermal jxn
dermatitis herpetiformis: defn
assoc with celiac disease; anti-gliadin Ig may cross react with regions of dermal papillae
who when where: dermatitis herpetiformis
males > females
20-40s (3rd,4th decades)
extensor surfaces, elbows, knees, upper back, buttocks
lesions: dermatitis herpetiformis
papule, vesicle, occasionally bullae over erythematous or urticarial base
intensely pruritic
dermatitis herpetiformis: histopathology
earl lesions: fibrin and PMNs accumulate in tips of dermal papillae ->microabscesses
vacuolization of overlying basal cells
small regions of dermoepidermal separation->subepidermal blister
direct immunoflourescence dermatitis herpetiformis
granular deposites of IgA (!!!) in tips of dermal papillae (