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15 Cards in this Set
- Front
- Back
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pemphigus: defn
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autoimmune
IgG against desmosomes of squamous epithelial cells weak cell-celladherence with friction blistering disease of skin and mucosa |
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what is the most common type of pemphigus?
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pemphigus vulgaris (80%)
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who gets pemphigus vulgaris and where?
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30-50yo (4-6th decades)
points of pressure; scalp, face, axilla, groin, trunk |
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lesions in pemphigus vulgaris
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inital oral ulcers
primary lesions-superficial vesicles and bullae easily rupture->shallow erosion with dried serum crust |
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histopathology pemphigus vulgaris
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suprabasal acantholysis (loss of intercell adhesion)
intraepidermal blister "tombstone" layer of basal cells form floor of blister inflamm below blister |
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direct immunoflourescence in pemphigus vulgaris
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IgG deposits along PM of keratinocytes-> fishnet pattern
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bullous pemphigoid:defn (who)
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relatively common autoimmune, vesiculobullous disease
IgG against BM (Ag assoc with hemidesmosomes) elderly |
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lesions bullous pemphigoid
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resemble friction blister
clear fluid <2cm (smaller than pemphigus) resist rupture inner thigh,flexor surface of arm, axilla |
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histopathology bullous pemphigoid
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subepidermal blister (epidermis normal)
basal cell layer vacuolization-> blister superficial dermal edema |
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direct immunoflourescence: bullous pemphigoid
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linear deposition of C' at dermoepidermal jxn
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dermatitis herpetiformis: defn
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rare
assoc with celiac disease; anti-gliadin Ig may cross react with regions of dermal papillae |
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who when where: dermatitis herpetiformis
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males > females
20-40s (3rd,4th decades) extensor surfaces, elbows, knees, upper back, buttocks |
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lesions: dermatitis herpetiformis
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papule, vesicle, occasionally bullae over erythematous or urticarial base
intensely pruritic |
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dermatitis herpetiformis: histopathology
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earl lesions: fibrin and PMNs accumulate in tips of dermal papillae ->microabscesses
vacuolization of overlying basal cells small regions of dermoepidermal separation->subepidermal blister |
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direct immunoflourescence dermatitis herpetiformis
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granular deposites of IgA (!!!) in tips of dermal papillae (
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