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30 Cards in this Set

  • Front
  • Back
2 general types of repair
resolution: when injury caused minimal tissue damage
repair: when injury caused extensive tissue damage
what occurs in resolution?
neutralize chemicals
restore blood Q
remove dead tissue, edema
difference b/w lobar and bronchopneumonia (lobular)
lobular: pneumonia scattered and at different stages; spread via coughing to diff regions
lobar: all tissue of one lobe affected and at same stage; spread via pores of kohn (b/w alveoli)
how does lobar pneumonia heal? what is the other type?
crisis healing: ~ all at once (uncommon)
other: lysis healing
what occurs during repair?
replace dead cells with NEW CELLS via regeneration or via CT
regeneration in repair
orderly proliferation of same type of cell
req stem cells
degrees of cell activity
labile- fast turnover; unlimited (ex: skin, GI)
stable- can be stim to proliferate (ex: liver)
permanent- ex: neurons, cardiac
stem cells- asymmetric division
types of stem cells
embryonic- pleuripotent
adult- restricted (except BM, maybe epidermal-hair bulb, cornea)
control of cell growth
contact inhibition
GF: competence factors (req to induce DNA syn) and progression factors (induce DNA syn in competent cells)
epidermal GF
epithelial cells, fibroblasts
share R with TGF-a
platelet-derived GF
a competent factor
induces prolif in fibroblasts, sm m. monocytes
fibroblast GF
affinity for heparin (anionic)
induces anfiogenesis
prod by MPh
binds EGF receptor
induce fibroblast proliferation
stim collagen syn
TNF angiogenic
induces angiogenesis (NEW bld vessel growth)
incr vascular permeability
ONLY on endothelial cells
how does the liver regenerate after a lobe is removed?
enlargement of lobes that remain (compensatory growth)
restitution of fxnal MASS rather than form
what are 2 important cytokines and 2 important GF involved in liver regeneration?
IL-6, *TNF (G0/G1 transition)
why is the BM important for repair?
required as a structure upon which the epithelium can regenerate
what makes up the ECM?
structural proteins: collagens, elastins
adhesive glycoproteins:
proteoglycans and GAGs: gag=hyaluroic acid
whats the difference in repair b/w necrotic and toxic damage?
necrotic usually destroys BM; difficult to repair epithelium

toxic damage to BM can be prevented early and epithelium can be regenerated
BM components
collagen 4
components of interstitial matrix
3 types of adhesive glycoproteins
fibronectin: conn integrins in cells to ECM
integrins: dimeric; transmbr; conn cytoskeleton to fibronectin
laminin: most abundant; cross-shaped; bind mbr receptors to ECM
sequence of events in repair by CT
migration/proliferation of fibroblasts
deposit ECM
remodel scar
angiogenesis: process
degrade BM
endothelial cells migrate
endothelial cells proliferate
2 types of blood vessel formation
1. angiogenesis- from pre-existing vessels
2. from endothelial precursor cells of Bone marrow
2 types of wound healing
primary union/1st intention: surgical incision, minimal damage
secondary union/2nd intention: more extensive loss of cells and tissue, intense inflamm, *contraction of wound, granulation tissue
what is wound dehiscence
when a wound opens
what factors prevent wound healing?
foreign bodies
low venous drainage
low blood supply
what are complications of wound healing?
cicatrization- scar contraction
keloid- XS scar
pyogenic granuloma- exuberant granular tissue