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28 Cards in this Set

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translocation, gene, & CD for Follicular lymphoma
t(14;18),
BCL-2,
CD10+
translocation & gene for Burkitt lymphoma
t(8;14),
C-MYC

"Mike Burkitt"
translocation & gene for
MALT lymphoma
t(11;18),
MALT-1

"You gotta be 18 to order 11 malt beers!"
translocation & gene for
Mantle cell lymphoma
t(11;14),
CYCLIN D1

"there's a biCYCLe on the MANTLE!"
pseudonodule "growth center"
SLL
What are the types of NHL
(non-Hodgkins Lymphomas)
Note: 1-5 are Mature B cell lymphomas, 6 is Mature T cell lymphoma

1. Follicular Lymphoma (MC)
2. Diffuse Large B-cell Lymph
3. Small Lymphotyc Lymph (SLL)
4. Burkitt Lymphoma
5. MALT Lymphoma
6. Mycosis Fungoides (MF)/Sezary Syndrome (T cell lymphoma)
"starry sky sppearance"
Burkitt Lymphoma
(benign macrophages-->starry sky)
Lymphoma assoc w/H. pylori gastritis, Sjogren syndrome, Hashimoto thyroiditis
MALT Lymphoma
CD of MALT Lymphoma
*CD5-, *CD10-
(but has CD19, CD20, sIg (all assoc w/B cells)
lymphoma--waxing and waning
Mycosis Fungoides (MF)/Sezary Syndrome
lymphoma--"waxing and waning"
Mycosis Fungoides (MF)/Sezary syndrome
which dz has "cerebriform" nuclei in epidermis (Pautrier's abscesses)
Mycosis Fungoides (MF)/Sezary syndrome
CD of MF/Sezary
CD 4 and 3
morphology of Follicular Lymphoma
FL resembles nl germinal center of lymphoid follicles:
follicle center cells, centroblasts (lg noncleaved),
centrocytes (sml cleaved)
morph of Diffuse Large B cell lymphoma
"large" lymphocytes w/dispersed (like "diffuse") (vesicular) chromatin and prominent nucleoli
morph of SLL
-diffuse (not follicular)
-small round lymphocytes (not cleaved)
-pseudonodules "growth center"
morph of Burkitt Lymphoma
-loss of nl arch
-diffuse lymphoid infiltrate
-blue cytoplasm
-"starry sky" appearnce (macrophages)
-high grade, sm noncleaved
morph of MALT lymphoma
-reactive benign germinal centers
-lymphoepithelial lesions (lymphocytes infiltrate and destroy epithelium of crypts, ducts, and glands)
MC cutaneous T-cell lymphoma
MF/Sezary syndrome
Reed Sternberg cells
Hodgkin Lymphoma
morph of Hodgkin Lymphoma
Reed Sternberg cells
cervical lympadenopathy or mediastinal mass
Hodgkin Lymhoma
progressive skin lesions from skin rashes-->plaque-->tumor
MF/sezary
"cerebiform" nuclei in epidermis (Pautrier's abscesses) and upper dermis
MF/sezary
et of Hodgkins
infxn/viral
EBV
immunodeficiency
sezary syndrome?
peripheral blood involvement by MF
what are Reed Sternberg cells
in Hodgkins lymphoma, scattered lg tumor cells on background of inflammatory cells
CD of Reed Sternberg cells
CD30+, CD15+, (CD20-)