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13 Cards in this Set

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target cells indicate
hemoglobinopathies,
post-splenectomy
positive Coombs Test indicates
Immune-mediated (IgG or C3) hemolysis
what is hereditary spherocytosis?
Hereditary spherocytosis results from defect in spectrin, ankyrin, band 4.1 proteins (cytoskeleton proteins)
-->abnl cytoskeleton of RBC's result in spherocytic shape-->these abnl RBC's destroyed in spleen-->anemia,
Sx of hereditary spherocytosis
-extravascular hemolysis
-chronic anemia, splenomgaly, aplsastic crisis
lab tests of hereditary spherocytosis
spherocytes
increased osmotic fragility
negative direct coombs (DAT)
hereditary elliptocytosis
like hereditary spherocytosis--abnl interaxn of cytoskeleton proteins ankyrin, band 4.1, and spectrin
-->increased # of oval, elongated red cells (elliptocytes)
how is hereditary elliptocytosis inherited?
how bad is it?
-AD
-mild and well-compensated
G6PD Deficiency
no G6PD to regen NADPH, which is needed to regen GSH (reduced glutathione)
-->RBC's not able to deal with toxic insults-->buildup of oxidized cellulr products (Heinz bodies)-->premature RBC lysis in spleen and hemolytic anemia
inheritance pattern of G6PD deficiency
X-recessive
-can be triggered by moth balls & fava beans
lab tests of G6PD deficiency
-Extravascular hemolysis
-Bite cells
-Heinz body stain
target cells + intracellular Hgb crystals
Hemoglobin C Dz
Causes of Microangiopathic Hemolytic Anemia
1. HUS
2. TTP
3. DIC
4. Malignant HTN
Microspherocytes suggest:
Extravascular hemolysis:
1. Hereditary spherocytosis
2. G6PD deficiency
3. Immune hemolytic anemia