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15 Cards in this Set

  • Front
  • Back
name 3 types of HNPCC
1) Lynch I=colon
2) LynchII=CUB=colon, uterus, breast
3) Muir Torre=colon, sebaceous adenoma, others
what genetic problem in HNPCC
mutation in DNA repair gene results in dinucleotide instability
name types non-neoplastic polyps
inflamm (IBD), juvenile (4-6), Peutx Jegher
what genetic mutation of FAP (chrom, gene name, inheritance)
chrom 5, mutation in APC gene, AD
besides GI, abd pain in Crohns could be? in UC?
cholesterol gallstones, UC think PSC esp when jaundiced, etc
skin manifestation in Crohns
erythema nodosum
PBC assoc? PSC assoc?
PBC-female, autoimmune
what part GI tract Crohn's usu involve
term ileum, SI, colon (rectal sparing)
risks stomach cancer
nitrosamines, achlorhydia, chornic gastritis
risk colon cancer
villous adenomas, IBD, low fiber, incr age, FAP/HNPCC/FHx
ab in celiac (3)
antigliaden, antiendomysial, anti-tissue translutaminase
risks eso cancer
EtOH, smoke, barrette's, diverticuli, plummer-vinson, familiar
EtOH a risk for what cancers
eso, most H and N, HCC,
risks uterine cancer
estrogen, obesity, DM, HTN
risks cervical cancer
early sex, multiple sex partners, ?smoking? (assoc HPV 16, 18, 31, 33)