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34 Cards in this Set
- Front
- Back
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is inflammation specific?
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NONONONONO! immunity is
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what are the side effects of inflammation
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scarring
allergic response |
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what are two types of inflammation
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chronic >90 days
acute |
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describe the initiation of acute inflammation
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subtance released from injured cells
direct stimulus to mast cells microbial products expore of BM complement activation deposition of antigen antibody comploex disruption of vascular integrity |
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what are the five symptoms of acute inlammation
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rubor
calor dolor tumor loss of function |
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what goes on in acute inflammation
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vasconstriction to promote coagulation
vasodiation to increase blood flow edema migration of wbcs |
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what vasodilates first
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precapillary arterials so opens up more capillary beds to flid loss
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what is transudate
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fgluid with little protein (what leaks first)
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what is exudate
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loss of plasma from local capillary beds
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with loss of plasma... RBC becomes concentrated causing ____
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stasis
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what are the first cells to the scene
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neutrophils
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what is margination
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neutrophils accumulate besdie the endothelial cell lining
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what is emigration
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leukocytes squeeze between endothelial cells into the intersitial space
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what are the benefits of exudation
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dilutes toxins
increases pain release of circulating antibodies fosters phagocytsois |
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describe the immediate transient response
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endothelial cell contraction
increase in intercellular gaps elecitied by histamine bradykinin and leukotriene maximum exudation occurs with vasodilation of arterioled and vsoconstrictio of benules --> flood |
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what are five leukocytic events
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margination
adhesion emigration chemotaxis phagocytosis |
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what comes after neutrophils
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monocytes
become macrophages |
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binding of chemotactic agents by specifric receptors triggers cell in ____
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activated phagocytic state
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what are some chemotactic agetns
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soluble bacterial products
complement like C5a cytokines leukotrine B3 |
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phagocytosis is greatly enhance by ____
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opsonins
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binding of ___ antigbody triggers complement cascade and the C3b coats targeted particle
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IgG
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what is enfulfment
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pseudopods fromt he WBC surround the particle and orm a phagocytic vaculos
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what does lysozyme do
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breaks down bacterial cell walls
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what is hageman factor
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activates proteases
kingene complement coagulation fibrinolytic system |
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hageman factor = clotting factor ___
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XII
12 |
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describe the hageman factor flow
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trauma or damage leads to hageman factor activation
then four cascades 1. coagulation 2. fibrolytic 3. kinin fibrolytic leads to 4. complement |
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how are the coagulatio and fibrolytic cascade related
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coagulation
and coagulation limitations |
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activated hageman factor converts prekallikrein to
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kallikrein
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kallikrean cleaves kininogen to produce
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several vasoactive peptides called kinins
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what are C5-C9
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membrane attack complex
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what does the mac attack do
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punches holes in bacterial cells walls
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what is C3a-C5a
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anaphylatoxins increase vascular permeability enchance smooth muscle contractio and lead to histamine release
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what is C5a
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activates the lipoxygenase pathway and activates leukocytes
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waht is C3b do
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opsonin helps with phagocytosis
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