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8 Cards in this Set

  • Front
  • Back
Endocrine cells are located in?

Exocrine cells are called?
Islets of Langerhans

Acinar cells
Alpha cells
Beta cells
Delta cells
F cells
Glucagon (Catabolic)
Insulin (Anabolic)
Somatostatin (inhibitory)
Pancreatic Polypeptide
GH, Glucocorticoids, Progesterone, and Estrogen increase ____A____ by increasing ____B_____
A. Insulin concentration
B. Peripheral Resistance to Insulin
Hyperfunction of the Endocrine Pancreas
Hyperinsulinism:
usually Iatrogenic insulin OD
can have Fnxnl Islet Cell Tumor (ferret, benign > dog malignant >> cat)

Glucagon-secreting tumors (rare) - leads to superficial necrolytic dermatitis
Hypofunction of the Enodcrine Pancreas

IDDM
NIDDM
(Non) Insulin Dependent Diabetes Mellitus

Dogs - IDDM (poodle, schauzer, bichon, cairn terrier, fox terrier, maltese - and more)
Cats - either (and go back and forth)

no histo change IN the islet - but the islets may be lost or decreased in size
Constellation of Systemic Changes with DM
Hyperglycemia -> Glucosuria -> osmotic diuresis -> PU/PD
Cataracts -> glucose in eye converted to Sorbitol by aldose reductase
Glomerulopathy/Sclerosis
Stress Hormones
Tumors of Paraganglia (non-chromaffin paraganglia)
1. Aortic Body TUmor (aka Heart Base Tumor or Chemodectoma)
rare - most frequent in Boxers and Boston Terriers
adenoma more common than carcinoma

2. Carotid Body Tumor
rare --- near carotid bifurcation
Hyperfunction of Neuroendocrine Cells
Carcinoid Tumors

rare