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8 Cards in this Set
- Front
- Back
Endocrine cells are located in?
Exocrine cells are called? |
Islets of Langerhans
Acinar cells |
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Alpha cells
Beta cells Delta cells F cells |
Glucagon (Catabolic)
Insulin (Anabolic) Somatostatin (inhibitory) Pancreatic Polypeptide |
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GH, Glucocorticoids, Progesterone, and Estrogen increase ____A____ by increasing ____B_____
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A. Insulin concentration
B. Peripheral Resistance to Insulin |
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Hyperfunction of the Endocrine Pancreas
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Hyperinsulinism:
usually Iatrogenic insulin OD can have Fnxnl Islet Cell Tumor (ferret, benign > dog malignant >> cat) Glucagon-secreting tumors (rare) - leads to superficial necrolytic dermatitis |
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Hypofunction of the Enodcrine Pancreas
IDDM NIDDM |
(Non) Insulin Dependent Diabetes Mellitus
Dogs - IDDM (poodle, schauzer, bichon, cairn terrier, fox terrier, maltese - and more) Cats - either (and go back and forth) no histo change IN the islet - but the islets may be lost or decreased in size |
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Constellation of Systemic Changes with DM
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Hyperglycemia -> Glucosuria -> osmotic diuresis -> PU/PD
Cataracts -> glucose in eye converted to Sorbitol by aldose reductase Glomerulopathy/Sclerosis Stress Hormones |
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Tumors of Paraganglia (non-chromaffin paraganglia)
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1. Aortic Body TUmor (aka Heart Base Tumor or Chemodectoma)
rare - most frequent in Boxers and Boston Terriers adenoma more common than carcinoma 2. Carotid Body Tumor rare --- near carotid bifurcation |
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Hyperfunction of Neuroendocrine Cells
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Carcinoid Tumors
rare |