Path - Ch 20 - Hematopathology

Front 1

Dx: translocation involving PML1 gene and RAR gene (t(15:17)) which results in encoding of functional RAR allowing maturation of tumor cells

Back 1

acute promyelocytic leukemia (APL)

Front 2

Frequent presenting disorder of APL

Back 2

DIC

Front 3

Dx: t(9:22)(q34:q11) with bcr/abl encoding p190

Back 3

acute lymphocytic leukemia (ALL)

Front 4

neoplasms composed of pre-T or pre-B cells

Back 4

acute lymphocytic leukemia (ALL)

Front 5

Dx: PAS positive, peroxidase negative, TdT positive, CD 19 and CD 10

Back 5

pre-B ALL

Front 6

Dx: PAS positive, peroxidase negative, TdT positive, CD 1, 2, 5, 7

Back 6

pre-T ALL

Front 7

Dx: t(8;21) or inv(16) that encode products that inhibit terminal differentiation

Back 7

acute myelogenous leukemia (AML)

Front 8

AML classification: blasts lack def cytological markers of myeloblasts (myeloperoxidase neg) but express myeloid lineage antigens

Back 8

M0 - min differentiated

Front 9

AML classification: very immature, > 3% blasts, peroxidase positive, few granules or Auer rods

Back 9

M1 - without differentiation

Front 10

AML classification: full range of myeloid maturation through granulocytes, Auer rods present, associated with t(8:21)

Back 10

M2 - with maturation

Front 11

AML classification: most cells are hypergranular promyelocytes with many Auer rods, associated with t(15:17)

Back 11

M3 - APL

Front 12

AML classification: myelocytic and monocytic differentiation, monoblasts are pos for nonspecific esterases, associated with inv(16)

Back 12

M4 - acute myelomonocytic leukemia

Front 13

AML classification: monoblasts and promonocytes predominate in blood

Back 13

M5 - acute monocytic leukemia

Front 14

AML classification: dysplastic erythroid precursors predominate, >30% myeloblasts

Back 14

M6 - acute erythroleukemia

Front 15

AML classification: megakaryote blasts predominate, react with Ab against GPIIb/IIIa or vWF, myelofibrosis

Back 15

M7 - acute megakaryocytic leukemia

Front 16

Dx: staining for CD 33 and 34 is positive

Back 16

AML

Front 17

Dx: staining for CD 41 and 61 is positive

Back 17

AML with megakaryote involvement

Front 18

Dx: smudge cells in the PBS

Back 18

CLL/SLL

Front 19

Dx: expression of CD19, 20, 23 and 5, deletions of 13q, 11q, 12q or 17p

Back 19

CLL/SLL

Front 20

Dx: t(9:22)(q34:q11) with bcr/abl encoding p210

Back 20

CML

Front 21

Dx: clonal B cell prolif of sm to med sized lymphocytes, occurs largely in older men

Back 21

hairy cell leukemia

Front 22

Dx: positive for tartrate-resistant acid phosphatase (TRAP)

Back 22

hairy cell leukemia

Front 23

Most common type of Hodgkins lymphoma

Back 23

nodular schlerosing

Front 24

Dx: Reed-Sternberg cells

Back 24

Hodgkins lymphoma

Front 25

Lyphoma with no leukemic state

Back 25

Hodgkins lymphoma

Front 26

What is the Ricter transformation?

Back 26

change from CLL/SLL to large cell lymphoma

Front 27

Dx: IgM spike, hyperviscosity

Back 27

Waldenstrom disease (lymphoplasmic lymphoma)

Front 28

Dx: cutaneous T cell lymphoma with Pautrier microabscesses

Back 28

mycosis fungoides

Front 29

Infection with HHV-8 can cause which non-Hodgkins lymphoma?

Back 29

diffuse

Front 30

Dx: t(8:14) with starry sky appearance

Back 30

Burkitt lymphoma

Front 31

Dx: t(11:14) with CD 5, 19, 20

Back 31

mantle cell NHL

Front 32

NHL associated with H pylori infection

Back 32

marginal zone

Front 33

lymphoma involving plasma cells

Back 33

multiple myeloma

Front 34

Most common complication of multiple myeloma

Back 34

amyloid nephropathy

Front 35

Dx: PAS positive hyaline microthrombin with schistocytes in PBS

Back 35

TTP

Front 36

# of platelets to dx essential thrombocythemia

Back 36

>= 600,000