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36 Cards in this Set

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Dx: translocation involving PML1 gene and RAR gene (t(15:17)) which results in encoding of functional RAR allowing maturation of tumor cells
acute promyelocytic leukemia (APL)
Frequent presenting disorder of APL
DIC
Dx: t(9:22)(q34:q11) with bcr/abl encoding p190
acute lymphocytic leukemia (ALL)
neoplasms composed of pre-T or pre-B cells
acute lymphocytic leukemia (ALL)
Dx: PAS positive, peroxidase negative, TdT positive, CD 19 and CD 10
pre-B ALL
Dx: PAS positive, peroxidase negative, TdT positive, CD 1, 2, 5, 7
pre-T ALL
Dx: t(8;21) or inv(16) that encode products that inhibit terminal differentiation
acute myelogenous leukemia (AML)
AML classification: blasts lack def cytological markers of myeloblasts (myeloperoxidase neg) but express myeloid lineage antigens
M0 - min differentiated
AML classification: very immature, > 3% blasts, peroxidase positive, few granules or Auer rods
M1 - without differentiation
AML classification: full range of myeloid maturation through granulocytes, Auer rods present, associated with t(8:21)
M2 - with maturation
AML classification: most cells are hypergranular promyelocytes with many Auer rods, associated with t(15:17)
M3 - APL
AML classification: myelocytic and monocytic differentiation, monoblasts are pos for nonspecific esterases, associated with inv(16)
M4 - acute myelomonocytic leukemia
AML classification: monoblasts and promonocytes predominate in blood
M5 - acute monocytic leukemia
AML classification: dysplastic erythroid precursors predominate, >30% myeloblasts
M6 - acute erythroleukemia
AML classification: megakaryote blasts predominate, react with Ab against GPIIb/IIIa or vWF, myelofibrosis
M7 - acute megakaryocytic leukemia
Dx: staining for CD 33 and 34 is positive
AML
Dx: staining for CD 41 and 61 is positive
AML with megakaryote involvement
Dx: smudge cells in the PBS
CLL/SLL
Dx: expression of CD19, 20, 23 and 5, deletions of 13q, 11q, 12q or 17p
CLL/SLL
Dx: t(9:22)(q34:q11) with bcr/abl encoding p210
CML
Dx: clonal B cell prolif of sm to med sized lymphocytes, occurs largely in older men
hairy cell leukemia
Dx: positive for tartrate-resistant acid phosphatase (TRAP)
hairy cell leukemia
Most common type of Hodgkins lymphoma
nodular schlerosing
Dx: Reed-Sternberg cells
Hodgkins lymphoma
Lyphoma with no leukemic state
Hodgkins lymphoma
What is the Ricter transformation?
change from CLL/SLL to large cell lymphoma
Dx: IgM spike, hyperviscosity
Waldenstrom disease (lymphoplasmic lymphoma)
Dx: cutaneous T cell lymphoma with Pautrier microabscesses
mycosis fungoides
Infection with HHV-8 can cause which non-Hodgkins lymphoma?
diffuse
Dx: t(8:14) with starry sky appearance
Burkitt lymphoma
Dx: t(11:14) with CD 5, 19, 20
mantle cell NHL
NHL associated with H pylori infection
marginal zone
lymphoma involving plasma cells
multiple myeloma
Most common complication of multiple myeloma
amyloid nephropathy
Dx: PAS positive hyaline microthrombin with schistocytes in PBS
TTP
# of platelets to dx essential thrombocythemia
>= 600,000