Path Block 1

Front 1

what are some of the blistering autoimmune diseases

Back 1

-pemphigus
-bullous pemphigoid
-dermatitis herpatiformis

Front 2

what is the common characteristic of subroneal blister

Back 2

they are usually at the epidermal level, the roof of the bulla is usuallu stratus corneum

Front 3

-what is the main characteristic of a suprbabsal blister
-what is this indicative of

Back 3

they are located just below the basal layer, and the stratus corneum forms the roof
-this usually indicative of pemphigus vulgaris

Front 4

-what is the main characteristic of subepidermal blister
-what is this indicative of

Back 4

in this case the entire blister seperates form the basal layer
-dermatitis hepatoformis

Front 5

whar the s n s of pemphigus

Back 5

-autoimmune disease with antibody (IgG) launched against the desmosomes of the aquamous epithelial cells
-anti desmogline antibody

Front 6

what is the use of desmososme

Back 6

-its the glue that holds cells together and if it is destroyed the cell tend to sepeprate

Front 7

what are the s n s of P. vulgaris

Back 7

-it is the most common type of pemphigus
-involves mucosa
-groin
-axilla
-face and other pressure points

Front 8

what is the histopathic distinction of P.vulgaris

Back 8

- on slide it results in a suprabasal acanthylosis w/c leads to an intraepidermal blister in which rounded acantholytic epidermal cells are identified

Front 9

what are the s n s of bullous pemphigoid

Back 9

-caused by antibody to skin basement membrane and leading to formation of a subepidermal blister
-it is a clear fluid filled blister less than 2cm, usually caused by friction
-it is generally seen in older individuals on the inner aspects of legs, axilla, and flexor surface of ar

Front 10

what 2 features differentiate bullous pemphigoid form pemphigus vulgaris

Back 10

-they differ b/c bullous is less than 2cm and and it doesn't effect the mucosa as much as p. vulgaris

Front 11

what are histopathic distinctions of bullous pemphigoid

Back 11

-you can see the seperation of the epidermis from dermis
-also there is subepidermal cleft that may be filled woth PMN, EOSINOPHILLS and that may lead to the destruction of the basal layer
-also there is ribbon candy deposition of of complement
-mainly effects lamina lucida

Front 12

what are s n s of dermatitis herpetiformis

Back 12

-rare disorder that effects male more than females in 3rd and 4th decade or 20 and 30
-major association with celiac disorder and anti gliadin ab, w.c may croos react with drmal papillae
-intensely puritic plaques and vesicles located on th eextensor surfaces, elbows, knees, upper back and butt,pressure areas
-"resembles herpes"

Front 13

what are some of the histopath s n s of dermatitis herpetiform

Back 13

-mainly intact erythmatous blisters often grouped together
-usually raised lesion that is usually removed by scratching
-their are many neutrophilic microabsesses involving the dermal papilla

Front 14

what is the antibody seen dermatitis herpetiform

Back 14

IgA

Front 15

w/c zone is involve with dermatitis herpetiform

Back 15

papillary dermis and the blister forms at the dermal apidermal junction