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29 Cards in this Set
- Front
- Back
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PROcoagulant state of the endothelium can be initiated by (3)
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1) Tissue factor being exposed
2) Collagen exposed 3) Activation of endothelium by cytokines or chemical mediators |
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Coumarin or Warfarin does what?
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Inhibits Vitamin K in the production of coagulation factors
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What are Vitamin K dependent clotting factors?
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Prothrombin (II), factors 7, 9, 10
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Most coagulation factors are proteins synthesized in the
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Liver
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What is primary hemostasis?
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Platelets contact collagen
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What is secondary hemostasis?
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Coagulation cascade
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What does tPA do?
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Cleaves plasminogen to plasmin
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What does plasmin do?
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Digests fibrin clot
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Confinement is regulated by
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tPA and thrombomodulin
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A vWF defect will affect...
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Adhesion of platelets
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vWF is found where?
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Endothelium and circulating bound to factor 8
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The Factor 8-vWF complex does what?
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Accelerates platelet binding to exposed collagen
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Thrombin converts
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Fibrinogen-->Fibrin
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First factor in intrinsic coagulation pathway?
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Hageman Factor or Factor 12
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Factor Xa does what
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Converts prothrombin to thrombin
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Two granules released by platelets
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ADP and Thromboxane A2
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What is hemostasis?
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Stop bleeding
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What is syneresis?
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Clot retraction that expels serum
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Tissue factor initiates which pathway?
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Extrinsic coagulation cascade
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Collagen and HMWK initiate which pathway?
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Intrinsic coagulation cascade
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What does heparin do?
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Increases AT-III activity, secreted by basophils and mast cells
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What does protein C do?
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Cleaves activated factors V and VIII
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What does thrombomodulin do?
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Binds thrombin to activate protein C, which cleaves factors V and VIII
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What does vWF do?
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Anchors platelets to subendothelial collagen
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Factor VIII has longer half life when bound to vWF
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Notes
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What does thrombin activate?
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Factors 5, 8, and fibrinogen
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What does factor V do?
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Accelerates prothrombin to thrombin
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What does factor VIII do?
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Accelerates X to Xa
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Fibrin Stabilizing factor cross links fibrin
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Notes
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