Path 404 Sp 2008 Chronic Inflammation

Front 1

What are the features of chronic inflammation, disregarding the power windows, power locks, and AM/FM Cassette? How is this different than acute inflammation?

Back 1

edema, redness, heat, pain, loss of function; less pronounced and more variable in their intensity

Front 2

What does the pathogenesis of chronic inflammation involve? In other words, what are the two main characteristics of chronic inflammation?

Back 2

persistence of the causative agent, a host reaction that is predominantly immunological

Front 3

What are the two characteristic agents that the body employs as part of the chronic inflammatory response?

Back 3

T lymphocytes to attack the offending agent and/or B lymphocytes to produce antibodies to it

Front 4

granulomatous inflammation

Back 4

occurs in response to certain indigestible organisms (Tuberculosis) and is characterized by large numbers of marcophages that engulf the antigenic agent

Front 5

epithelioid cells

Back 5

macrophages in granulomatous inflammation that resemble epithelial cells because of their abundant cytoplasm and close approximation to each other in aggregates

Front 6

What type of necrosis do granulomas undergo?

Back 6

caseous (cheese-like) necrosis

Front 7

sarcoidosis

Back 7

a relatively common granulomatous disease characterized by widespread noncaseous granulomas

Front 8

regeneration

Back 8

multiplication of healthy, neighboring cells surrounding necrotic cells; different cell types have varying degrees of regeneration

Front 9

labile cells

Back 9

great capacity for regeneration (epidermis, mucosal lining of the intestinal tract, bone marrow)

Front 10

stable cells

Back 10

intermediate capacity for regeneration (most tissue cells)

Front 11

permanent cells

Back 11

"These cells have a trbl capacity to regenerate," says Sir Charles Barkley. (neurons, lung tissue, renal glomeruli)

Front 12

fibrosis

Back 12

formation of a dense, tough mass of collagen called a scar

Front 13

Which is better, regeneration or fibrous connective tissue repair?

Back 13

Regeneration, because normal function is usually restored.

Front 14

collagen

Back 14

main protein of connective tissue

Front 15

organization

Back 15

another name for fibrous connective tissue repair

Front 16

granulation tissue

Back 16

consists of fibroblasts and capillaries that bring nutrients to the site of repair and remove liquefied necrotic tissue

Front 17

What are the two phases of fibrous repair?

Back 17

granulation tissue stage and scar formation stage

Front 18

resolution

Back 18

refers to the removal of dead tissue during the granulation tissue stage of fibrous connective tissue repair

Front 19

fibroblasts

Back 19

initiate the stage of scar formation by laying down collagen

Front 20

What are the two types of wound repair?

Back 20

primary union and secondary union

Front 21

primary union

Back 21

closure of wound using sutures or tape, heals more quickly than secondary union

Front 22

secondary union

Back 22

due to size or extent of wound, closure of wound is not possible; instead, granulation tissue forms across the wound and eventually epithelial tissue forms (large wounds may need skin grafts)

Front 23

debridement

Back 23

part of medical care which includes removal of foreign material and necrotic tissue from a wound

Front 24

keloid

Back 24

an overgrowth of fibrous tissue in wound healing

Front 25

Name six modifying factors or wound repair

Back 25

1. virulence of the infective organisms
2. advancing age
3. poor nutrition
4. diabetes
5. steroid therapy
6. chronicity of the insult