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31 Cards in this Set
- Front
- Back
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Cardiomyopathy?
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disease due to primary abnormality of myocardium
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Myocarditis?
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inflammation primary cause of myocardial injury
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3 types of cardiomyopathy?
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dialated
hypertrophic restrictive |
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EF of dialated cardiomyopathy?
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<40 systolic
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EF of hypertrophic cardiomyopathy?
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50-80 diastolic
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EF of restrictive cardiomyopathy?
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45-90 diastolic
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Clinical features of dialated cardiomyopathy?
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progressive CHF
EF <25 death in 2 yrs of 50% of pts (CHF, arrhythmias, emboli) |
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Heart features in dialated cardiomyopathy?
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hypertrophy
dilatation contractile, systolic, dysfxn |
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Etiology of cadiomyopathy?
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idiopathic - myocarditis
toxic - ethanol,catecholamines, adriamycin Genetics metabolic - hemochroatosis, thyroid disease neuromuscular pregnancy |
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Gross pathology of dilated cardiomyopathy
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hypertrophy
enlarged 2-3Xs mural thrombi vessels & valves are normal |
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Mirco pathology of cardiomyopathy
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myocardial fibers hypertrophied
large hyperchromatic boxcar nuclei patchy interstitial fibrosis |
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Overview of hypertrophic cardiomyopathy
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abnormal diastolic filling
LV outflow obstruction |
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Clinical presentation of hypertrophic cardiomyopathy
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exertional dyspnea
angia 2nd to ischemia A fib- mural thrombi- emboli intractable CHF ventricular arrhythmias sudden death |
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etiology of hypertrophic cardiomyopathy
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1/2 familial autosomal dominant
multiple genes involved |
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Gross pathology of hypertrophic cardiomyopathy
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septal muscle hypertrophy
LV bannana shaped |
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micro pathology in hypertrophic cardiomyopathy
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myocytes of septum are in disarray
interstitial fibrosis of septum hypertrophy of myocytes |
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overview of restrictive cardiomyopathy
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decreased compliance
diasolic impaired filling |
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What is associated wiht restrictive cardiomyopathy
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post-radiation fibrosis
amyloidosis sarcoidosis metastatic tumors inborn errors of metabolism |
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Right ventricular cardiomyopahty
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hypoplastic thin RV
familial in 1/2 chr 14 |
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Clinical presentation of RV cardiomyopathy
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arrhytmias
sudden death |
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pathology of RV cardiomyopathy
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thinned RV muscle
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Etiology of myocarditis
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infectious
immune unknown idiopathic |
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Infectious causes of myocarditis
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viral - coxackie A/B, CMV
bacteria- lyme fungi protozoa - chagas helminths - trichinosis |
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immune causes of myocarditis
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post viral
post streptococcal lupus drugs transplant rejection |
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unknown causes of myocarditis
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sarcoidosis
giant cell myocarditis |
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clinical features of myocarditis
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assymptomatic
heart failure arrythmias sudden death percusor to dilated cardiomyopathy |
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gross pathology of myocarditis
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normal
mural thrombi 2nd to arrythmia dialated |
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micro pathology of myocarditis
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inflam infiltrate w myocyte damage
lymphocytic! neutrophilic & eosinophilic granulomatous inflam giant cell inflam |
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Acute rejection mild
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perivascular lymphocytes
no myoctye damage no tx |
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acute rejection moderate
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mural lymphocytes with some myocyte damage
treat |
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acute rejection severe
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mural lymphocytes
neutrophils hemorrhage wiht micro infarcts may not be reversible |
