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32 Cards in this Set
- Front
- Back
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Encountered during acute phase of inflammatory response
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PMN
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Have granulocytes and lobed nuclei
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PMN
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Pale pink granules
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neutrophils
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Take up eosin to stain bright red
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eosinophil
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Take up basophilic stains to be dark blue
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basophils
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Do granulocytes divide
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NO
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Most common WBC
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neutrophil
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Make up to 75% in WBC of most animals except cattle/rabbits
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neutrophils
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1-10% of wbc
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eosinophil
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really rare
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basophils
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encountered in long term inflammatory responses
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mononuclear leukocyte
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do NOT have lobed nuclei
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mononuclear leukocyte
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Two forms of mononuclear leukocyte
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monocytes and lymphocytes
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Most common type of mononuclear leukocyte
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lymphocyte
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Mononuclear cell not found in blood
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mast cell
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Key actors in acute inflammatory response
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neutrophils
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Unstable and short lived in circulation
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neutrophils
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What are the granules in neutrophils?
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lysosomes
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Contain myeloperoxidase
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azurophil granules
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Most of stromal degradative enzymes and lactoferrin and adhesion
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specific granules
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Rapidly responds to chemoattractants
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neutrophil
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Responds especially to complement fragments
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neutrophil
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Also called margination
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reversible adherence
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Adherence by surface molecules on WBC and endothelin by
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selectins
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Irreversible process called
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pavementing if right chem mediators around
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Good at stimulating irreversible process
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IL-1 and TNF alpha
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Can flood an area in 30 minutes
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neutrophils
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Function 2 of neutrophils
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phagocytosis
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Respiratory burst first bi-product
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o2-
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O2- reacts with itself or H+ to make
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H2O2
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If Fe present what radical forms
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hydroxyl
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Myeloperoxidase is present mainly in what
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azurophil granules
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