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24 Cards in this Set
- Front
- Back
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3 year old boy presents with back pain, decreased activity, bruising, and is pale. CD markers are (+) for CD19 and CD10. there is a t(12;21) detected on FISH. What is the DD and what is the likely prognosis?
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B-ALL
good prognosis |
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55 year old presents with fatigue, frequent nose bleeds and infections, swollen painful gums, but no swollen lymph nodes and a granulocytic sarcoma in his lung.
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AML
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Disorder characterized by recurrent cytogenetic abnormalites such as t(8;21), inv(16), t(15;17), 11q23, and MDS related changes
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AML
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12 year old boy presents with abdominal pain and night sweats. A tumor is found in his abdomen. Peripheral blood shows 4% bands. Immunotyping is (+) for CD19/ CD10/ CD20. What is the DD?
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Burkitt Leukemia/lymphoma
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9 month old with a fever, and petechiae (pin point rash), 66%blasts on CBC, on flow cytometry showed MPO (+) and (+) CD 13, 33, & 117.
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AML
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13 year old boy presents w/ epitaxis of 3 days, normal WBCs, dec platelets, 74%blasts, and a t(15;17).
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APL (acute promyelocytic leukemia)
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19 y/o finished treatment for lymphoblastic lymphoma 1.5 yrs ago. On a checkup he has pancytopenia, 14% blasts, and dysplastic cells on biopsy.
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Therapy-related MDS
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70 yr old man complains of progressive weakness on routine physical. He attributes this to his current "head cold." On examination he has numerous bruises, and a CBC shows severe cytopenias with 10% blasts. BM aspirate reveals ringed sideroblasts, hypolobulated MKs, and myeloid blasts w/ Auer Rods.
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MDS
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55 yr old presents with a 1 month history of weakness and weight loss. On exam extreme splenomegaly is noted. CBC shows anemia, and leukoerythroblastosis. Philadelphia chromosome is present.
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CML
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52 yr old woman is transported to the hospital for a MI. On physical exam her legs are red and her lips and fingers have a bluish tinge. On history she complains of recent headaches, GI problems, inc bleeding while flossing, and itching after showering.CBC reveals thrombocytosis, high hematocrit & hemoglbin, but low EPO. Her only current medication is for treatment of Gout.
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Polycythemia vera (PV)
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65 year old male presents with fever, night sweats, weight loss, massive splenomegaly, moderate hepatomegaly, and hyperuricemia. Blood smear shows dacrocytosis. BM tap is dry. BM biopsy is shown.
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PMF (primary myelofibrosis)
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65 yr old Patient presents with leg pain, with a red, swollen, warm leg. Patient also complains of a throbbing burning sensation in his hands and feet. On CBC, platelets are found to be over 1 mill/uL. BM biopsy is shown.
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ET (essential thrombocytosis)
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70 year old man presents with fatigue, wt loss and anorexia. He has lymphadenopathy, hepatospleniomegaly, hypogammaglobinemia, and decreased haptoglobin, smudge cells on blood smear, diffuse infiltration of lymph node, CD 5, 19, 20, 23, and 79a (+). Genetics show a 13q14.3 deletion which you know is a good prognostic feature of what neoplasm?
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CLL
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Neoplasm characterized by t(14;18), CD 10 (+), Bcl-6 (+), and Bcl-2 (+). Lymphadenopathy is painless and neoplasm is treated with low-dose chemo.
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Follicular lymphoma
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Neoplasm characterized by mucosal lymphoepithelial lesions, is associated with chronic inflammation (H. pylori gastitis, Sjogren disease, Hashimoto thyroiditis), expressed B-cell markers but is CD5 and CD10 (-)
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Marginal Zone lymphoma
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Ceoplasm characterized by its poor prognosis. Phonotype markers show B-cells with CD5 (+) but CD 23 (-), and cyclin D1 (+).
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Mantle cell lymphoma
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8 year old boy presents with a large mandibular mass. Mass biopsy is shown. cells display B-cell markers, CD10 (+), Bcl-6 (+), and a t(8;14) translocation
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Burkitt lymphoma
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Aggressive neoplasm with B-cell surface markers, age >60, presents with a rapidly enlarging mass, nodal or extranodal. cytogenetics are varied but may involve a t(14;18) or Bcl-6 disregulation.
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Diffuse large B-cell lymphoma
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65 year old ethiopian man presents with bone pain, fatigue, recurrent infections, polydipsia, and constipation. Blood smear shows Rouleaux formation, Dutcher and russell bodies. X-ray shows punched out lesions.
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multiple myeloma
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28 year old male presents with splenomegaly, fever, weightloss, fatigue, and painless cervical lymphadenopathy. He is found to have a normochromic normocytic anemia, and inc LDH. Biopsy shoes RS cells CD30+ CD15+ CD20-.
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Hodgkin Lymphoma
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Aggressive noplasm CD3, CD4+, common in Asian decent.
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peripheral T-cell lymphoma
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Lymphoma of the skin, forming an intra-epithelial abscess, that shows characteristic CD4+ cerebriform cells. usually indolent.
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mycosis fungoides
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Neoplasm characteristic with the ALK protein, CD30+, the Hallmark cell on blood smear, and a t(2;5).
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Anaplastic Large Cell Lymophoma
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After a trip to the caribbean a 54 year old woman presents with skin lesions, lymphadenopathy, hypercalcemia, and CD4+/CD25+ flower cells. You suspect infection of HTLV-1 virus.
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Adult T-cell leukemia/lymphoma
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