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Epithelial hyperplasias of Breast



Two types

Orderly and atypical hyperplasia



Know acronym

_rderly and _typical hyperplasia

Epithelial hyperplasia of breast



Two types



Acronym

o


A



Hyperplasia

Orderly


Atypical

Epithelial hyperplasia of breast



Two types

Orderly and atypical hyperplasias

Epithelial hyperplasia of breast



Two types



new test


new topic

Orderly vs. atypical hyperplasia

Orderly hyperplasia


Epithelium: increased but maintain normal geography and cellular apperances



Atypical hyperplasia


Architecture of the cells: becomes abnormal


Cytology of the cells: altered


Can be found in: ductual and lobular patterns

Epithelium is increased but maintaqins normal geography and cellular appearance

Orderly hyperplasia



___________: increased but maintains normal geography and cellular appearance

epithelium

Orderly hyperplasia



_________: increased but maintains normal geography and cellular appearance

Epithelium: _________ but maintains _________ geography and cellular appearance



Orderly or atypical?

Orderly


increased


normal

Orderly hyperplasia



_______: _________ but maintains _______ geography and cellular appearance.

Epithelium: increased but __________ normal ______ and cellular ________.



Orderly or atypical

orderly


maintains


geography


apperance

Orderly hyperplasia



Epithelium: ________ but _____ normal _________ and cellular _______.

Epithelium: increased ____ maintains ______ geography and __________ appearance.

but


normal


cellular

Orderly hyperplasia



________: __________ but ________ __________ _________ and ________ __________

Epithelium: increased ____ maintains normal geography ____ cellular appearance

but


and

Orderly hyperplasia



Test

Epithelium: increased but maintains normal geography and cellular appearance



The other one?

Atypical hyperplasia

Atypical hyperplasia

Architecture of the cells: becomes abnormal


Cytology of the cells: altered


Can be found in ductual or lobular patterns.

Architecture of the cells: becomes abnormal


Cytology of the cells: altered


Can be found in ductual or lobular patterns.



Orderly or atypical

Atypical



Orderly?

Epithelium: increased but maintains normal geography and cellular appearance

Atypical hyperplasia


Architecture of the ______: becomes ________


Cytology of the ______: altered


Can be found in ductual or lobular _______.

cells


abnormal



cells



patterns



Orderly - def?

Epithelium: increased but maintains normal geography and cellular appearance

Atypical hyperplasia


Architecture of the _____: becomes ________


Cytology of the ______ : altered


Can be found in ductual or lobular ________.

___________ of the cells: ______ abnormal


_______ of the cells: __________


Can be ______ in D______ or L_______ patterns

architecture


becomes



cytology


altered



found


ductual


lobular

Atypical hyperplasia


___________ of the cells: ______ abnormal


_______ of the cells: __________


Can be ______ in ______ or _______ patterns

Architecture of the _____: becomes ___________


Cytology of the ____: altered


_________ found in ductual or lobular ________.



Orderly or atypical?

atypical



cells


abnormal


cells


can be


patterns

Atypical hyperplasia



___________ of the _____: ______________


_______ of the ______: __________


________ be ______ in ______ or ________________

Architecture of the cells: becomes abnormal


Cytology of the cells: altered


Can be found in ductual or lobular patterns.



The other one?


-name


-def

Orderly hyperplasia


Epithelium is increased but maintains normal geography and cellular appearance

Atypical hyperplasia


vs.


Orderly hyperplasia

Architecture of the cells: becomes abnormal


Cytology of the cells: altered


Can be found in ductual or lobular patterns.



Orderly hyperplasia


Epithelium is increased but maintains normal geography and cellular appearance



These are the pathologies of what oragn?


Cancer risk?

Breast



Atypical: significantly risk - 5 times


Without atypical: slightly increased - 1.5-2 times

Orderly hyperplasia


vs.


Atypical hyperplasia



Cancer risk

Without atypical: slightly increased - 1.5-2 times



Atypical: significantly increased risk: 5 times

Orderly hyperplasia


vs.


Atypical hyperplasia



Cancer risk


Without atypical: __________ increased - 1.5-2 times



Atypical: ___________ increased risk: 5 times


slightly


significant



Review: orderly hyperplasia

Epithelium: increased but maintains normal geography and cellular appearance

Orderly hyperplasia


vs.


Atypical hyperplasia



Cancer risk


________ atypical: _________ increased - 1.5-2 _______



__________: ___________ increased risk: 5 _________

Cancer risk


Without _________: slightly ________- ______-__ times



__________: significantly _____________: __ times

Cancer risk


Without atypical: slightly increased - 1.5-2 times



Atypical: significantly increased risk: 5 times

Orderly hyperplasia


vs.


Atypical hyperplasia



Cancer risk


__________: _____________ - _____-____ ____



_________: _______________: ____________

Cancer risk


Without atypical: slightly increased - 1.5-2 times



Atypical: significantly increased risk: 5 times



Review


Atypical hyperplasia

Architecture of the cells: becomes abnormal


Cytology of the cells: altered


Can be found in ductual or lobular patterns.

Orderly hyperplasia


vs.


Atypical hyperplasia



Cancer risk

Without atypical: slightly increased - 1.5-2 times



Atypical: significantly increased risk: 5 times

Name one breast neoplasms

fibroadenoma

Name one breast neoplasms



acronym

F

Fibroadenoma

Name one breast neoplasms

fibroadenoma+Prevalence

Most common benign neoplasm of breast

Fibroadenoma



Prevalence

Most common benign neoplasm of breast

___ _______ ______ ______ of ________

Fibroadenoma



Prevalence

_____________________ of ______

Most common benign neoplasm


breast

fibroadenoma



Prevalence


Test

Most common benign neoplasm of breast



Peak incidence

3rd decade

firboadenoma



Prevalence


Peak incidence

Most common benign neoplasm of breast



____ decade

3rd decade

fibroadenoma



Prevalence


Peak incidence

Most common benign neoplasm of breast



3rd decade



Usual appearance

Usually solitary and discrete

firboadenoma



Prevalence


Peak incidence


Usual appearance

Most common benign neoplasm of breast


3rd decade



Usually sol______ and dis______

solitary


discrete

Fibroadenoma



Usual appearance

Usually s_____________ and d__________



Disease?


Prevalence


Peak incidence

solitary


discrete



fibroadenoma



most common benign neoplasm of breast



3rd decade


fibroadenoma



usual appearance

Usually ___________ and _______

solitary


discrete

fibroadenoma



Prevalence


Peak incidence


Usual appearance

Most common benign neoplasm of breast


3rd decade


Usually solitary and discrete



Change in appearance

May enlrage with menstrual cycle and during pregnancy

Fibroadenoma



Change in appearance

May ______ with menstrual cycle and during pregnancy



peak incidence

enlarge



3rd decade

Fibroadenoma



Change in appearance


May ______ with menstrual cycle and during pregnancy

_____ enlarge with menstrual ______ and during _________



Prevalence

may


cycle


pregnancy



Most common benign neoplasm of breast

FIbroadenoma



Change in appearance


_____ enlarge with menstrual ____ and during _______.

May _____ with _______ cycle and _________ pregnancy



Usual appearance/behavior

enlarge


menstrual


during



Usually solitary and discrete

fibroadenoma



Change in appearance



May ___________ with _________ and ____________

enlarge


menstrual cycle


during pregnancy



Prevalence


Peak incidence


Usual appearance

Most common benign neoplasm of breast



3rd decade


usually solitary and discrete

fibroadenoma



Change in appearance

May enlarge with menstrual cycle and during pregnancy



Prevalence


Peak incidence


Usual appearance

Most common benign neoplasm of breast


3 rd decade



usually solitary and discrete

Carcinoma of the breast



Notes: risk factors

More common in North America


Uncommon in women under 30


5-10% related to specific inherited mutations


Family history


Prolonged exposure to exogenous estrogens postmenopausally


Ionizing radiation



How many types there are?

2

Carcinoma of the breast



2 types


List

Non-invasive


Invasive



Know acronym

carcinoma of the breast




2 types



acronym

N


I

Non-invasive


Invasive

Carcinoma of the breast



2 types

Non-invasive


invasive

Carcinoma of the breast



___________


invasive

non-invasive


Def.

Has not invaded basement membrane into fat

Carcinoma of the breast


Non-invasive



Def.

Has not invaded basement membrane into fat

_____ not _____ _____ _____ into ____

Carcinoma of the beast


Non-invasive



Def.


Has not invaded ______ membrane into fat

Has not ________ basement _______ into _____

invaded


membrane


fat

Carcinoma of the breast


Non-invasive



Def.


________________________ into _____

has not invaded basement membrane _____ fat

into

Carcinoma of the breast


non-invasive



Def.

Has not invaded basement membrane into fat



The other one?

Invasive

Carcinoma of the breast


Invasive



Def.

Invades out of ducts and lobules



Non-invasive?

Has not invaded basement membrane into fat

Carcinoma of the breast


Invasive



Def.


Invades out of _____ and lobules

_______ out of ducts and ______

invades


lobules

Carcinoma of the breast


invasive



def.


______ out of _____ and ______

Invades ______ ducts and ____.

out of


lobules

Carcinoma of the breast


invasive



_________ of _________ and _______

Invades out


ducts


lobules



Non-invasive

has not invaded basement membrane into fat

Carcinoma of the breast


invasive



Def.

Invades out of ducts and lobules



Non-invasive

Has not invaded basement membrane into fat

Carcinoma of the breast


invasive vs. non-invasive



Def.

Invades out of ducts and lobules vs.


have not invaded basement membrane into fat



aka for non-invasive

in-situ

Carcinoma of the breast


non-invasive



Subtypes

1. Ductual or Lobular



2. Carcinoma in-situ



See notes

Ductual carcinoma in-situ


Lobular carcinoma in-situ

Carcinoma of the breast


non-invasive



Subtypes



1. Ductual or Lobular


2. Carcinoma in-________

1. D__________ or L ______________


2. ___________ ___-situ

Ductual


lobular


carcinoma


in

Carcinoma of the breast


non-invasive



Subtypes



1. _____________ or ___________


2. _____________ ___-_____

ductual


lobular


carcinoma in-situ

Carcinoma of the breast


non-invasive



Subtypes

1. Ductual or lobular


2. carcinoma in-situ



Review


Def of non-invasive

Hasnot invaded basement membrane into fat

Carcinoma of the breast


Invasive



Review


Def.

Invades out of ducts and lobules



Subtypes

1. invasive


2. ductual or lobular


3. Carcinoma



1. Less common


1.1Medullary, colloid, tubular


1.2 Carcinoma

Carcinoma of the breast


Invasive



Subtypes

1. __________


2. Ductual or lobular


3. Car_____________



1. _____Common


1.1 medullary, colloid, tubular


1.2 Car__________

Invasive


carcinoma



less


carcinoma

Carcinoma of the breast


Invasive



Subtypes


1. __________


2. Ductual or lobular


3. _____________



1. _____Common


1.1 medullary, colloid, tubular


1.2 _____________

1. Invasive


2. Ductual or _______


3. Carcinoma



1. Less ______


1.1 Med______, Col____, tub______


1.2 carcinoma

lobular


common


medullary


colloid


tubular

1. __________


2. __________ or _____________


3. _____________



1. Less ______


1.1 m________, __________, _________


1.2 __________

1. invasive


2. ductual or lobular


3. Carcinoma



1. Less common


1.1Medullary, colloid, tubular


1.2 Carcinoma

Carcinoma of the breast


Invasive



Subtypes


1. __________


2. ______ or __


3. __



1. _______________


1.1 _____, ______, ________


1.2 ________

1. invasive


2. ductual or lobular


3. Carcinoma



1. Less common


1.1Medullary, colloid, tubular


1.2 Carcinoma

Carcinoma of the breast


Invasive



Subtypes

1. invasive


2. ductual or lobular


3. Carcinoma



1. Less common


1.1Medullary, colloid, tubular


1.2 Carcinoma



Name one complications/variations of carcinoma of breast

pagets disease of nipple

Pagets disease of nipple



Type of disease

Complications/variations of carcinoma of the breast



Name one

Pagets disease of nipple

Name one complications/variations of carcinoma of the breast

Pagets disease of nipple



Clinical presentation

Progress of DCIS into lactiferous ducts and skin of nipples

Pagets disease of nipple



Clinical presentation

Progress of DCIS into lactiferous ducts and skin of nipple

Pagets disease of nipple



Clinical presentation



___________ of DCIS into lactiferous ______ and skin of ______


Progress of _____ into _______ ducts and ____ of nipple

DCIS


lactiferous


skin

Pagets disease of nipple



Clinical presentation



_______ of __________ into _______ _______ and ______ of ______


Progress ____ DCIS ______ lactiferous ducts _____ skin ____ nipple

of


into


and


of

Pagets disease of nipple



Clinical presentation


Progress of DCIS into lactiferous ducts and skin of nipple