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4 Cards in this Set
- Front
- Back
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Oncogenes
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GAIN OF FUNCTION --> CANCER
* Need damage to only 1 allele 1. abl --> CML, ALL 2. c-myc --> Burkitt's 3. bcl2 --> Follicular lymphoma 4. erb-B2 --> Breast,ovarian,gastric CA 5. ras --> colon, bladder, lung, pancreas, kidney CA - dec GTPase activity --> trapped in activated GTP-bound state 6. L-myc --> Lung tumor 7. Nmyc --> Neuroblastoma, small cell lung 8. ret --> MEN I & II 9. c-kit --> GIST |
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Tumor suppressor genes
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Loss of Function --> CANCER
* Both alleles must be LOST for dz 1. Rb = 13q --> Retinoblastoma, osteosarcoma - regulates G1/S checkpoint - Active = HYPOphosphorylated --> stops cell cycle - Inactive = HYPERphosphorylated (abn phosphorylation) --> allows cell to proceed thru checkpt 2. BRCA1 = 17q --> Breast/Ov CA 3. BRCA2 = 13q --> Breast 4. p53 = 17p --> LiFraumeni 5. p16 = 9p --> Melanoma 6. APC = 5q --> Colorectal CA |
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Tumor suppressor genes (cont.)
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7. WT1 = 11p --> Wilm's tumor
8. NF1 = 17q --> Neurofibromatosis 1 9. NF2 = 22q --> Neurofibromatosis 2 10. DPC = 18q --> Pancreatic CA 11. DCC = 18q --> Colon CA |
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Tensilon Test
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MG: improvement/ resolution of weakness
LE : No clinical improvement |
