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31 Cards in this Set
- Front
- Back
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what do hst-1 and int-2 code for?
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fibroblast growth factors
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what tumors assocd with hst-1 and int-2 oncogenes?
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stomach, breast, bladder, melanoma
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what tumors associated with sis oncogene?
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astrocytoma
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what does sis code for?
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PDGF
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what do erb-B1, B2 and B3 code for?
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epidermal growth factor receptors
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what tumor is assocd with erb-B1?
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SCC of lung
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what tumors are assocd with erb-B2?
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breast, ovary, lung
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what tumor is assocd with erb-B3?
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breast
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what does ret code for?
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glial neurotrophic factor receptor
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what tumors are assocd with the ret oncogene?
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MEN II, MEN III, familial thyroid (medullary) cancer
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what does abl code for?
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cytoplasmic and nuclear tyrosine kinase - bcr-abl fusion protein
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what tumors are associated with the abl oncogene?
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CML, ALL
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what tumors are associated with the ras oncogene?
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lung, pancreas, colon
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what does ras code for?
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GTP binding protein
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what do the myc oncogenes code for?
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nuclear regulatory proteins
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what tumor is assocd with the c-myc oncogene?
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Burkitt lymphoma - t(8;14)
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what tumor is assocd with the L-myc oncogene?
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SCLC
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what tumor is assocd with the N-myc oncogene?
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neuroblastoma
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what does bcl-1 code for?
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cyclin D protein (cell cycle regulator)
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what tumor is assocd with the bcl-1 oncogene?
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mantle cell lymphoma - t(11;14)
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what does the CDK4 oncogene code for?
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cyclin dependent kinase (cell cycle regulator)
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what tumors are assocd with CDK4 oncogene?
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melanoma, GBM
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what is the function of bcl-2?
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prevents apoptosis
(translocated and overexpressed in follicular lymphomas) |
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what genes promote apoptosis?
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bax, bad, bcl-xS, bid
p53 promotes apoptosis by stimulating bax synthesis |
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what tumor suppressor gene is on chromosome 3?
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VHL
(vonHippel Lindau dz, renal cell carcinoma) |
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what tumor suppressor genes are on chromosome 11?
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WT-1 and 2
(Wilms tumor) |
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what tumor suppressor genes are on chromosome 13?
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Rb
(retinoblastoma, osteosarcoma) BRCA-2 (hered. breast CA) |
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what tumor suppressor genes are on chromosome 17?
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p53 (all kinds of tumors)
BRCA-1 (hered. breast and ovarian CA) NF-1 (neurofibromas) |
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what tumor suppressor gene is on chromosome 5?
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APC
(adenomatous polyps and colon CA) |
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what tumor suppressor gene is on chromosome 18?
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DCC
(deleted in colon CA) |
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what tumor suppressor gene is on chromosome 22?
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NF-2
(acoustic neuromas/schwannomas, meningiomas) |
