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26 Cards in this Set
- Front
- Back
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Parvovirus family and species
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Parvoviridae
Parvovirinae |
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Parvovirus cat infection
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Feline panleukopenia virus
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Parvovirus dog infection
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Dog panleukopenia virus
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Parvovirus Mink infection
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Mink enteritis virus
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Parvovirus Pig infection
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Porcine parvovirus
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Mink, ferret parovirus
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Aleutian mink disease virus: Amdovirus
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Parvoviridae characteristics
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nonenveloped
small, 20 - 22 nm diameter icosahedral symmetry Environmentally stable: heat, desiccation, disinfection NA Hypochlorite effective |
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Parvovirus effect on cell cycle
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Will damage DNA so cell keeps replicating.
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Parvovirus infects
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GI crypts
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Parvovirus compensation for small size
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uses cellular enzymes
alternate splicing/initiation of mRNA virion assembly in nucleus released by cell lysis |
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Parvovirus replciates in
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rapidly dividing cells: GI epithelium, lymphoid tissue
fetal tissue |
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Parvovirus clinical signs
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fever, vomiting, bloody diarrhea, necrotizing enteritis, leukopenia, lymphoid necrosis, abortion, stillbirth, cerebellar hyposplasia
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Parvovirus pathologic changes:
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crypt necrosis, intranuclear inclusions, loss of villous epithelium, hemorrhage, 2nd bacterial infections
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Prenatal/neonatel infections
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cerebellar hypoplasia, ataxia
granular cell loss degeneration/loss of purkinje cells |
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Diagnosis of parvovirus
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clinical signs, leukopenia,
EM *** HI ELIZA - fecal antigen |
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Parvovirus TX
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supportive care
hydration, antibiotics |
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Parvovirus Transmission
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Feces (ingestion, inhalation)
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Parvovirus clinical signs
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fever, lymphpenia, vomiting, hemorrhagic enteritis
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Pathological changes
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destruction of crypt cells
lymphoid necrosis (thymus, spleen, LN, Peyer's patches) |
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Prenatal/neonatal infections in dogs
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myocarditis
mycardial degeneration, necrosis preferentially heart |
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Parvovirus dog diagnosis
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EM
ELISA (fecal Ag, serum IgG IgM virus isolation HE |
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Parvovirus dog treatment
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supportive care
prevent dehydration antibiotics Tamiflu (NA inhibitor) |
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Parvovirus Control in dogs
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vaccination (inactivated MLV)
quarantine disinfection |
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Ferret, Mink Parvoinfection
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disease similar to FPV and CPV-2,
genetically more closely related to FPV than CPV-2, |
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Reproductive disorders with parvovirus
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stillbirth, mummificaiton, embryonic death, infertility, resorption
poor doers or clear virus |
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Parvovirus transmission
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fecal oral route,(contaminated water, food, semen from boars
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