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37 Cards in this Set

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Acyclovir
To monophosphate: Inhib DNA Pol (we barely P-late it)
Resist by Defic Thymidine Kinase
Trt HSV
HSV Keratoconjunctivitis
Trifluridine
HSV Keratitis
Idoxuridine
Ganciclovir
Trt CMV
to Tri-P inhib DNA Pol
Amantadine
Ihhib Acid-Med uncoating
Propho Influenza A
Zanamivir
Inhib NA (neuraminidase)
"-na- = NA"
Zidovudine (AZT)
To Tri-P inhib DNA Pol (RT)
Saquinavir
HIV Protease Inhib
Interferon
Causes Protein Synth
Interferes w/Pen, Uncoat, Assembly
Amphotericin B
Binds Ergosterol forms pores
Enhances Flucytosine
Renal Tox Avoided w/Mannitol
Ketoconazole
Inhib CYP450:
Prvnt Ergosterol=block cell wall synth
Inc Conc of other drugs: Esp Cyclosporin in Solid Orgn Trnsplnt
Flucytosine
To FluoroUracil: Inhib Thymidilate Sythesis
We can't DeAminate it
Use w/Ampho B bc resistnce
PCP
Trim Sulfa
(+silver stain)
Griseofulvin
Disrupt microtubules
Vs Dermatophytes
Athletes Foot
Ring Worm
Atheletes Foot
Griseofulvin
Miconazole
Penicillins
vs G(+)
Interact w/PBP to stop Trans-peptidation (no wall synth)
PCN resistnt to B-Lactamase
Acid Labile:(L=MN)
Methicillin, Nafcillin
Acid Stable:(clox)
Oxacillin, Cloxacillin, Diclox
Imipenem/Clistatin
Imipenem rstnt to B-lactamase
Clistatin inhib renal clrnce
MRSA
Hosp= Vanc
Comm= T-S, Clindamycin
Vancomycin
Block cell wall synth
Bc prvnt release sugar-glycan
MRSA
Oral for C.Diff
Aminoglycosides
Bind 30S= Misread mRNA
1big dose 1xday
Dec Tox: Ototox, Nephrotox
Trim-Sulfa
Sulfa inhib DiHydropteroate
Trim inhib DHF Reductase
No synth Pyr/Pur
No synth Met, Gly, Ser
Tetracycline
Bind 30S=block tRNA to A site
Vs G(+)&G(-)
Ricket, Myco, Chlamidia
Not for Pneumo Pneumo
chelates Ca(teeth/bones)
Pneumococcal Pneumonia
Penicillin
Cephalosporin
Erythromycin
Clindamycin
Bind 50S=block transloc chn
Dev Pseudomem colitis
Pseudomembranous Colitis
Oral Metronidazole
Oral Vanc
Macrolides
Erythromycin, Clarith, Azith
Atypical Pneumonia: Erythro
DOC for Comm-Acquired Pneumo
TB
"RIPE"
Rifampin, Isoniazid, Pyrazinamide, Ethambutol
Inhib DNA Gyrase
Nalidixic Acid
Ciprofloxacin (FQ)
Prot Synth Inhib
"Buy AT 30, CELL at 50"
A=Aminoglycoside (cidal)
T=Tetracycline
C=Chloramphenicol
E=Erythromycin
L=Lincomycin
L=cLindamycin
Resist B-lactam in G(+)
Prod B-lactamases
Alter PBP (synthetic no work)
(MRSA alter PBP- Resist all B-lactams)
Resist B-lactam in G(-)
Prod B-lactamases
Reduce Permeability
(Dec #porins)
Resist Vanc
Vanc inhib cell wall synth
By bind D-Ala
Chng to D-lactate=Resistnt
Fluoroquinolone Resist
Pt mut DNA Gyrase
Macrolide Resist
"mycins"
Methylate 23S subunit of 50S
Tetracycline Resist
Efflux pump
Folate-Synth Inhib
Trim-Sulfa
Resist by form of Dihydropteroate Synthetase that doesnt bind Sulfonamides