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37 Cards in this Set
- Front
- Back
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Acyclovir
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To monophosphate: Inhib DNA Pol (we barely P-late it)
Resist by Defic Thymidine Kinase Trt HSV |
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HSV Keratoconjunctivitis
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Trifluridine
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HSV Keratitis
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Idoxuridine
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Ganciclovir
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Trt CMV
to Tri-P inhib DNA Pol |
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Amantadine
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Ihhib Acid-Med uncoating
Propho Influenza A |
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Zanamivir
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Inhib NA (neuraminidase)
"-na- = NA" |
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Zidovudine (AZT)
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To Tri-P inhib DNA Pol (RT)
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Saquinavir
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HIV Protease Inhib
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Interferon
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Causes Protein Synth
Interferes w/Pen, Uncoat, Assembly |
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Amphotericin B
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Binds Ergosterol forms pores
Enhances Flucytosine Renal Tox Avoided w/Mannitol |
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Ketoconazole
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Inhib CYP450:
Prvnt Ergosterol=block cell wall synth Inc Conc of other drugs: Esp Cyclosporin in Solid Orgn Trnsplnt |
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Flucytosine
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To FluoroUracil: Inhib Thymidilate Sythesis
We can't DeAminate it Use w/Ampho B bc resistnce |
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PCP
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Trim Sulfa
(+silver stain) |
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Griseofulvin
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Disrupt microtubules
Vs Dermatophytes Athletes Foot Ring Worm |
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Atheletes Foot
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Griseofulvin
Miconazole |
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Penicillins
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vs G(+)
Interact w/PBP to stop Trans-peptidation (no wall synth) |
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PCN resistnt to B-Lactamase
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Acid Labile:(L=MN)
Methicillin, Nafcillin Acid Stable:(clox) Oxacillin, Cloxacillin, Diclox |
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Imipenem/Clistatin
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Imipenem rstnt to B-lactamase
Clistatin inhib renal clrnce |
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MRSA
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Hosp= Vanc
Comm= T-S, Clindamycin |
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Vancomycin
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Block cell wall synth
Bc prvnt release sugar-glycan MRSA Oral for C.Diff |
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Aminoglycosides
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Bind 30S= Misread mRNA
1big dose 1xday Dec Tox: Ototox, Nephrotox |
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Trim-Sulfa
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Sulfa inhib DiHydropteroate
Trim inhib DHF Reductase No synth Pyr/Pur No synth Met, Gly, Ser |
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Tetracycline
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Bind 30S=block tRNA to A site
Vs G(+)&G(-) Ricket, Myco, Chlamidia Not for Pneumo Pneumo chelates Ca(teeth/bones) |
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Pneumococcal Pneumonia
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Penicillin
Cephalosporin Erythromycin |
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Clindamycin
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Bind 50S=block transloc chn
Dev Pseudomem colitis |
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Pseudomembranous Colitis
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Oral Metronidazole
Oral Vanc |
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Macrolides
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Erythromycin, Clarith, Azith
Atypical Pneumonia: Erythro DOC for Comm-Acquired Pneumo |
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TB
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"RIPE"
Rifampin, Isoniazid, Pyrazinamide, Ethambutol |
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Inhib DNA Gyrase
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Nalidixic Acid
Ciprofloxacin (FQ) |
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Prot Synth Inhib
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"Buy AT 30, CELL at 50"
A=Aminoglycoside (cidal) T=Tetracycline C=Chloramphenicol E=Erythromycin L=Lincomycin L=cLindamycin |
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Resist B-lactam in G(+)
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Prod B-lactamases
Alter PBP (synthetic no work) (MRSA alter PBP- Resist all B-lactams) |
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Resist B-lactam in G(-)
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Prod B-lactamases
Reduce Permeability (Dec #porins) |
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Resist Vanc
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Vanc inhib cell wall synth
By bind D-Ala Chng to D-lactate=Resistnt |
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Fluoroquinolone Resist
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Pt mut DNA Gyrase
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Macrolide Resist
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"mycins"
Methylate 23S subunit of 50S |
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Tetracycline Resist
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Efflux pump
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Folate-Synth Inhib
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Trim-Sulfa
Resist by form of Dihydropteroate Synthetase that doesnt bind Sulfonamides |
