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40 Cards in this Set

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N1-R
Autonomic Ganglia

Ag= ACh, Nicotine
Ant= Hexamethonium
Hexamethonium
"put a HEX on ANS"

Block N1-R
N2-R
Skel Musc MEP

Ag= ACh, Nicotine, Succinyl
Ant= "curoniums", Curare
Lidocaine
"caine"= local anesthetic
Class IB
Only affects ventricles (Na+)
Accel RePol (K+)
Ondansetron
Prevent N/V
Block Na+Chnl coupled to 5HT3 in CTZ
Block L-Type Ca2+ Chnl
Nifedipine
Diltiazem
Verapamil
Ethosuximide
"sux to have seizures"
DOC Abscence seizure
Block T-type Ca2+ Chnl in CNS
Ketamine
block NMDA-R
Prvnting excit effect of glut
Dissociative Anesth/Halluc
Felbamate
block NMDA-R
Prvnt Seizures
Amiodarone
Sotalol
Delay Ventric RePol
Bc block K+ chnls
Glypizide
@Panc B-cells
close K+ chnls (cell Depol)
Ca+2 in & Act PLC- IP3/Ca
Insulin Secretion
Insulin Secretion
Glypizide- Inc
Diazoxide- Dec (opens K+chnl)
Baclofen
Inc GABA-med K conduc (Hyperpol)
Dec Excit glut in N.
Trt: Spasticity w/less sedate
Prvnt PRL release
D2-R in Ant Pit
Dopa, Bromocriptine, Pergolide
GABAa-R (HyperPol)
Enhnce: EtOH, Propofol,
BZ= Inc FREQUENCY open
Barbituate= Inc DURATION open
B1-R
(AC coupled via G)
Hrt: Inc HR, dp/dt,
Adipocytes: Lipolysis
JG cells: Inc Renin release
B2-R
(AC coupled via G)
Lungs: Bronchodilate, Inc FEV
Vasc: Vasodilate
Uterus: Relax (inhib birth)
Liver: Glycogenolysis
H2-R
(AC coupled via G)
relax VSM (direct & NO)
Vasodilate, Inc Gastric Acid
V2-R
ADH= Inc water ReAbs
Lithium= inhibits this cyclse
PDE Inhibitors
Theophylline= Neonatal Apnea
Papaverine= Erection
Dipyridamole= with Aspirin: Trt CHF (inc dp/dt)
Transduc via cGMP
THINK ANTI-ANGINAL!
NO, Nitroglycerine, Nitroprusside
Activate GC: cGMP relaxes VSM
Sildenafil
Erection:
Bc inhib type-V PDEase
(which usually degrades cGMP)
Muscarinic R
sphcincter iris, SM bronchioles, glands, SM GI and GB, Detrusor
a1-Adrenoceptor
Radial Muscle eye, VSM, trigone, Int sphincter GU
Digoxin
Depol lets Ca into cell
Blocks NA/K ATPase so less Ca extruded
Excess Ca stored in SR
Next Depol= Grtr SR Ca releas
Omeprazole
inhib gastric H+ pump
Furosemide
block Na/K/2Cl in Ascnd Limb
Thiazide Diuretic
Block Na/Cl in DT
Amiloride
Triamterene
Block Na chnl in PrincCell CD
Block H+ sec in CD
Glucocorticoids
Dec transcrip genes COX-2, IL-1, IL-6
Estrogens
Inc Hepatic synth Bind Globulin
Inc clot factors (2,7,9,10)
NSAIDS
prvnt Activate Nuc Factor Kappa-B
(prvnt exp genes for inflamm)
x-intercept
Bmax
Number of Receptors
slope
-1/KD
Affinity
(lower slope= dec affinity)
Graph Shifts
Right= Upreg/Inc R#
Left= Dwnreg/Dec R#
Pseudocholinesterase Defic
Neuromusc Block by Succinyl
lasts hours
NSAID + Anaphylaxis
Nasal Polyps
Bc all arachidonic acid to LKTs
(Hypersens)
Glu-6-P DH Defic
Hemolytic Anemia
Primaquine, Isoniazid, Sulfonamides, Nitrofurantoin
Slow Acetylators
SHIP
Sulfapyridine: hemoAnemia, Hep damage
Hydralazine: SLE-like
Isoniazid: Hep damage, Neuropathy
Procainamide: SLE-like
Neuroleptic Malig Synd
by rapid block Cent-DA-R
with typical Antipsychotics
(Haloperidol)
Resemble sev Parkinsons
Trt: Dantrolene+Bromocriptine