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40 Cards in this Set
- Front
- Back
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N1-R
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Autonomic Ganglia
Ag= ACh, Nicotine Ant= Hexamethonium |
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Hexamethonium
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"put a HEX on ANS"
Block N1-R |
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N2-R
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Skel Musc MEP
Ag= ACh, Nicotine, Succinyl Ant= "curoniums", Curare |
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Lidocaine
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"caine"= local anesthetic
Class IB Only affects ventricles (Na+) Accel RePol (K+) |
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Ondansetron
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Prevent N/V
Block Na+Chnl coupled to 5HT3 in CTZ |
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Block L-Type Ca2+ Chnl
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Nifedipine
Diltiazem Verapamil |
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Ethosuximide
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"sux to have seizures"
DOC Abscence seizure Block T-type Ca2+ Chnl in CNS |
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Ketamine
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block NMDA-R
Prvnting excit effect of glut Dissociative Anesth/Halluc |
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Felbamate
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block NMDA-R
Prvnt Seizures |
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Amiodarone
Sotalol |
Delay Ventric RePol
Bc block K+ chnls |
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Glypizide
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@Panc B-cells
close K+ chnls (cell Depol) Ca+2 in & Act PLC- IP3/Ca Insulin Secretion |
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Insulin Secretion
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Glypizide- Inc
Diazoxide- Dec (opens K+chnl) |
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Baclofen
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Inc GABA-med K conduc (Hyperpol)
Dec Excit glut in N. Trt: Spasticity w/less sedate |
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Prvnt PRL release
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D2-R in Ant Pit
Dopa, Bromocriptine, Pergolide |
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GABAa-R (HyperPol)
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Enhnce: EtOH, Propofol,
BZ= Inc FREQUENCY open Barbituate= Inc DURATION open |
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B1-R
(AC coupled via G) |
Hrt: Inc HR, dp/dt,
Adipocytes: Lipolysis JG cells: Inc Renin release |
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B2-R
(AC coupled via G) |
Lungs: Bronchodilate, Inc FEV
Vasc: Vasodilate Uterus: Relax (inhib birth) Liver: Glycogenolysis |
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H2-R
(AC coupled via G) |
relax VSM (direct & NO)
Vasodilate, Inc Gastric Acid |
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V2-R
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ADH= Inc water ReAbs
Lithium= inhibits this cyclse |
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PDE Inhibitors
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Theophylline= Neonatal Apnea
Papaverine= Erection Dipyridamole= with Aspirin: Trt CHF (inc dp/dt) |
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Transduc via cGMP
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THINK ANTI-ANGINAL!
NO, Nitroglycerine, Nitroprusside Activate GC: cGMP relaxes VSM |
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Sildenafil
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Erection:
Bc inhib type-V PDEase (which usually degrades cGMP) |
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Muscarinic R
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sphcincter iris, SM bronchioles, glands, SM GI and GB, Detrusor
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a1-Adrenoceptor
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Radial Muscle eye, VSM, trigone, Int sphincter GU
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Digoxin
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Depol lets Ca into cell
Blocks NA/K ATPase so less Ca extruded Excess Ca stored in SR Next Depol= Grtr SR Ca releas |
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Omeprazole
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inhib gastric H+ pump
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Furosemide
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block Na/K/2Cl in Ascnd Limb
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Thiazide Diuretic
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Block Na/Cl in DT
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Amiloride
Triamterene |
Block Na chnl in PrincCell CD
Block H+ sec in CD |
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Glucocorticoids
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Dec transcrip genes COX-2, IL-1, IL-6
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Estrogens
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Inc Hepatic synth Bind Globulin
Inc clot factors (2,7,9,10) |
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NSAIDS
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prvnt Activate Nuc Factor Kappa-B
(prvnt exp genes for inflamm) |
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x-intercept
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Bmax
Number of Receptors |
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slope
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-1/KD
Affinity (lower slope= dec affinity) |
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Graph Shifts
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Right= Upreg/Inc R#
Left= Dwnreg/Dec R# |
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Pseudocholinesterase Defic
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Neuromusc Block by Succinyl
lasts hours |
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NSAID + Anaphylaxis
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Nasal Polyps
Bc all arachidonic acid to LKTs (Hypersens) |
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Glu-6-P DH Defic
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Hemolytic Anemia
Primaquine, Isoniazid, Sulfonamides, Nitrofurantoin |
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Slow Acetylators
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SHIP
Sulfapyridine: hemoAnemia, Hep damage Hydralazine: SLE-like Isoniazid: Hep damage, Neuropathy Procainamide: SLE-like |
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Neuroleptic Malig Synd
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by rapid block Cent-DA-R
with typical Antipsychotics (Haloperidol) Resemble sev Parkinsons Trt: Dantrolene+Bromocriptine |
