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20 Cards in this Set
- Front
- Back
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PARKINSON’S DISEASE
SYMPTOMS |
– tremor at rest
– rigidity - difficult to initiate movement – advanced “frozen” state |
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PARKINSON’S DISEASE
CHRONIC PROGRESSIVE MOTOR DISORDER-3 |
– tremor at rest
– rigidity - difficult to initiate movement – advanced “frozen” state |
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PARKINSON’S DISEASE
SECONDARY SIGNS |
slurred speech, stooped posture, shuffling gait, pill rolling motion, depressed,apathetic
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PARKINSON’S DISEASE
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unknown
viral theries- unknown virus cerberal hypoxia(atherscolrosis-not enough blood flow) eps from antipsychotic agents |
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PARKINSON’S DISEASE
physiologic causes |
- DYSFUNCTION OF BASAL GANGLIA OF BRAIN (controls EPS)
- REDUCTION OF NUMBER OF DOPAMINE TERMINALS IN SUBSTANTIA NIGRA - IMBALANCE OF NEUROTRANSMITTERS DOPAMINE AND ACETYLCHOLINE |
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PARKINSON’S DISEASE
treatment choices-5 |
antihistamines
anticholinergics dopa dopa/carbidopa dopamine receptor stimulatns |
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PARKINSON’S DISEASE
anticholinergics thearaputeic use-used for |
minimal symptoms as adjunct therapy
drug induced parkinsons or eps |
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PARKINSON’S DISEASE
anticholinergics mechanism of action? |
blocks acetyl choline
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PARKINSON’S DISEASE
anticholinergics side effects?4 |
constipation
dry mouth blurred vision urinary retnetion |
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PARKINSON’S DISEASE
antihistamines |
block histamines
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PARKINSON’S DISEASE
antihistamines - theraputic uses-2 anticholinergic property strength? |
Therapeutic Use
– Elderly male- bc associated with urinary retntion mild to moderate anticholinergic proper are mild to moderate? – Drug induced Parkinson’s (EPS)-> my not be enough if use antihstamine n |
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PARKINSON’S DISEASE
antihistamines- Mechanism of Action – |
anticholinergic properties:mild to moderate
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PARKINSON’S DISEASE
what does decarboxylase enzyme do? |
converts dopa to dopamine
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PARKINSON’S DISEASE
what does carbidopa do? what kind of drug is carbidopa regarding its effects with otehr drugs? |
Carbidopa blocks decarboxylase enzyme
and is considered a potentiator |
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PARKINSON’S DISEASE
what can a high dose of dopa(grams) lead to quicker? |
quicker frozen state; use low dose to delay frozen state
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PARKINSON’S DISEASE
DOPA Therapeutics-3 no effect on what? why wouldnt you give to a psch patient? |
Relieves rigidity, decreases tremor, enhances mood
no effect on drug induced parkinsons(would make pscyhoctic) |
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PARKINSON’S DISEASE
DOPA Side effects/advers reactions-5 how do you control side effects? |
orthostatic hypotension, arrhythmogenic, nausea/vomiting,
psych disturbance, on/off(frozen state) – limit dose decreases side effects |
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PARKINSON’S DISEASE
DOPA Contraindiations-3 |
narrow angle glaucoma
acute psychosis(bc will become more psychotic if have more dopamine) -melanoma bc dopamine stimulates cancer |
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PARKINSON’S DISEASE
Amantadine what does it do? what kind of properties does it have? when do you use it? |
stimulates dopa receptor
antiviral properties when person is allergic to eggs(i.e. accine) |
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PARKINSON’S DISEASE
Amantadine side effects-3 |
insomnia
depression orthostatic hypotension |
