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7 Cards in this Set
- Front
- Back
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DA Pathway: Nigro-striatal?
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Motor system
Degeneration in Parkinson's Disease |
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DA Pathway: Mesolimbic-mesocortical?
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Emtions
Involved in Schizophrenia |
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DA Pathway: Tubero-infundibular?
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Endocrine Function
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What area degenerates in Parkinson's Disease? What is the characteristic pathological finding on slides?
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Substantia Nigra
Lewy Bodies in SN Neurons |
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What are the major neurotransmitters in the extrapyramidal system? Are they excitatory or inhibitory?
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Glutamate - excitatory
GABA - inhibitory Dopamine: D1 and D5 - "D1 type", increase adenylate cyclase D2, D3, D4 - "D2 type", decrease adenylate cyclase Acetylcholine: M1 - excitatory, increase IP3, decrease K+ conductance M2 - inhibitory, presynaptic inhibition, increased K+ conductance Peptides: enkephalin, dynorphin, substance P |
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What are the two neuronal pathways in the extrapyramidal system?
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Direct Pathway - Neurons express mainly D1 receptors, their activation leads to inhibition of inhibitory tone in the Thalamus, and therefore increased Thalamic input to cortex
Indirect Pathway - Striatal neurons mainly express D2 receptors, and their activation causes reduced inhibition of Thalamus via GPe and subthalamic nucleus |
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When there is genetic linkage in Parkinson's Disease, which genes are affected?
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alpha-synuclein, parkin, UCHL1 (enzyme involved in ubiquitin pathway) , LRRK
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