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23 Cards in this Set
- Front
- Back
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What are the goals of pharmacotherapy of PD?
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replace DA or modulate NT systems regulated by dopaminergic input
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What symptoms of PD?
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Resting tremor, bradykinesia, rigidity (masked facies), postural defects
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What is the function of the nigrostriatal system?
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motor behaviors
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What is the function of the mesolimbocortical system?
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learning, memory, emotions, affect, reward (degenerates in some PD)
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What is the function fo Hypothalamo-hypophyseal system?
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inhibiting prolactin secreation (not affected in PD
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What is the function of the chemoreceptor Trigger zone?
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DA receptor activation in the area postrema inuces nausea and vomiting
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What happens when you lose DA neurons?
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up-regulation of striatal DA receptors, disinhibition of indirect pathway, dysfacilitation of direct pathway
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What is L-Dopa?
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it is DA precusor used because DA can't cross BBB
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What is Carbidopa?
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is a peripheral dopa-decarboxylase inhibitor
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What are L-dopa and Carbidopa used for?
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67% effective for PD, elevation of growth hormone release, and hyperprolactinemia
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What the oral bioavailability of L-dopa?
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20-30%, but that is in the periphery
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What are the side effects of L-dopa and carbidopa?
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dykinesias, crazy psych problems, N/V
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What are Bromocriptine, ropinerol, pramipexole?
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DA receptor agonist D2, D2, D3
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What are the uses for bromocriptin, ropinerol, pramipexole?
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PD, hyperprolactinemia
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What is the oral bioavailability of bromocriptin, ropinerol, pramipexole?
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94% and it is highly bound to albumin
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What are the side effects of bromocryptine?
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anorexia, n/v, HoTN, cardiac arrhythmias, dykinesias, psych issues, colicky abdominal pain, constipation, blurred vision
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What is Amantadine?
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It is a DA releaser
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What is selegilin?
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MAO-B inhibitor
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What is selegilin broken down into?
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amphetamine
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What is talcopone?
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COMT inhibitor--dangerous to your liver
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What is Entacapone?
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COMT inhibitor--improves off-time
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What is benztropine?
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Anticholinergic agent
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What are the ADR of benztropine?
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cycloplegia, mydriasis, dry mouth, urinary retention
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